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Gene Gene information from NCBI Gene database.
Entrez ID 55142
Gene name HAUS augmin like complex subunit 2
Gene symbol HAUS2
Synonyms (NCBI Gene)
C15orf25CEP27HsT17025
Chromosome 15
Chromosome location 15q15.2
Summary The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
miRNA miRNA information provided by mirtarbase database.
407 Show/Hide all (407)
miRTarBase ID miRNA Experiments Reference
MIRT050510 hsa-miR-20a-5p CLASH 23622248
MIRT724554 hsa-miR-1298-3p HITS-CLIP 19536157
MIRT724552 hsa-miR-520g-3p HITS-CLIP 19536157
MIRT724551 hsa-miR-520h HITS-CLIP 19536157
MIRT724550 hsa-miR-186-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28 Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19369198, 20360068, 24981860, 25173975, 26496610, 30723163, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IBA
GO:0005813 Component Centrosome IDA 14654843, 21399614
GO:0005813 Component Centrosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613429 25530 ENSG00000137814
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NVX0
Protein name HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27)
Protein function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
PDB 7SQK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15003 HAUS2 8 → 190 HAUS augmin-like complex subunit 2 Family
Sequence
Sequence length 235
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Gastric cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations