H4C15 (H4 clustered histone 15)

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Gene Gene ontology Other IDs Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 554313
• Gene name: H4 clustered histone 15
• Gene symbol: H4C15
• Synonyms (NCBI Gene): H4-16, H4/o, H4C1, H4C11, H4C12, H4C13, H4C14, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, HIST2H4B
• Chromosome: 1
• Chromosome location: 1q21.2
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f

Gene ontology (GO) Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000786	Component	Nucleosome	IDA	14718166, 20498094, 21636898, 24699735, 25615412
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	20498094, 21812398, 24311584, 26694698
GO:0000786	Component	Nucleosome	TAS	3035717
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	3035717
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	9540062, 10220385, 14585971, 15161933, 15933069, 16415788, 16917504, 17540172, 18404153, 18408754, 18474616, 18571423, 19410544, 19494831, 19498464, 19710015, 19862764, 20000738, 20224553, 20498094, 20618440, 20709061, 20739937, 20951943, 21085121, 21478274, 21596426, 21743476, 2188
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14585971
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006334	Process	Nucleosome assembly	IDA	14718166, 20498094, 21636898, 24699735, 25615412
GO:0016020	Component	Membrane	HDA	19946888
GO:0030527	Function	Structural constituent of chromatin	IBA
GO:0030527	Function	Structural constituent of chromatin	IDA	14718166
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0043505	Component	CENP-A containing nucleosome	IPI	21743476
GO:0045653	Process	Negative regulation of megakaryocyte differentiation	IDA	18474616
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0061644	Process	Protein localization to CENP-A containing chromatin	NAS	21743476
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337, 23533145

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG Pathway	Reactome Pathway
Neutrophil extracellular trap formation	Recognition and association of DNA glycosylase with site containing an affected purine
Alcoholism	Cleavage of the damaged purine
Viral carcinogenesis	Packaging Of Telomere Ends
Systemic lupus erythematosus	Formation of the beta-catenin:TCF transactivating complex
	PRC2 methylates histones and DNA
	Condensation of Prophase Chromosomes
	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	HDACs deacetylate histones
	PKMTs methylate histone lysines
	HDMs demethylate histones
	HATs acetylate histones
	RMTs methylate histone arginines
	SIRT1 negatively regulates rRNA expression
	NoRC negatively regulates rRNA expression
	SUMOylation of chromatin organization proteins
	B-WICH complex positively regulates rRNA expression
	Transcriptional regulation by small RNAs
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Nonhomologous End-Joining (NHEJ)
	Processing of DNA double-strand break ends
	Deposition of new CENPA-containing nucleosomes at the centromere
	G2/M DNA damage checkpoint
	RNA Polymerase I Promoter Opening
	RNA Polymerase I Promoter Escape
	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
	Estrogen-dependent gene expression
	HCMV Early Events
	HCMV Late Events
	Amyloid fiber formation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

H4C9 36 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, SUMOylation of chromatin organization proteins, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +24 more Related via 36 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H4C1 36 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, SUMOylation of chromatin organization proteins, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +24 more Related via 36 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H4C4 36 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, SUMOylation of chromatin organization proteins, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +24 more Related via 36 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H4C6 36 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, SUMOylation of chromatin organization proteins, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +24 more Related via 36 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H4C12 36 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, SUMOylation of chromatin organization proteins, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +24 more Related via 36 shared pathways including Neutrophil extracellular trap formation, Alcoholism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
H4C9	0	[]	36	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","SUMOylation of chromatin organization proteins","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H4C1	0	[]	36	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","SUMOylation of chromatin organization proteins","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H4C4	0	[]	36	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","SUMOylation of chromatin organization proteins","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H4C6	0	[]	36	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","SUMOylation of chromatin organization proteins","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H4C12	0	[]	36	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","SUMOylation of chromatin organization proteins","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]

Diseases Linked via Similar Genes

Tessadori-van haaften neurodevelopmental syndrome Linked via 2 of 5 related genesH4C9, H4C1 Major depressive disorder Linked via 2 of 5 related genesH4C4, H4C12 Non-specific syndromic intellectual disability Linked via 1 of 5 related genesH4C9 Insomnia Linked via 1 of 5 related genesH4C1 Liver failure Linked via 1 of 5 related genesH4C1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Tessadori-van haaften neurodevelopmental syndrome	2	["H4C9","H4C1"]
Major depressive disorder	2	["H4C4","H4C12"]
Non-specific syndromic intellectual disability	1	["H4C9"]
Insomnia	1	["H4C1"]
Liver failure	1	["H4C1"]