H2BC17 (H2B clustered histone 17)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8348
• Gene name: H2B clustered histone 17
• Gene symbol: H2BC17
• Synonyms (NCBI Gene): H2B.2, H2B/n, H2BFN, HIST1H2BO, dJ193B12.2
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	NAS	1768865
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	NAS	1768865
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	16319397
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006334	Process	Nucleosome assembly	NAS	1768865
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0046982	Function	Protein heterodimerization activity	IEA

Other IDs

• MIM: 602808
• HGNC: 4758
• e!Ensembl: ENSG00000274641

Protein

• UniProt ID: P23527
• Protein name: Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)
• Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair,
• PDB: 7WLP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00125	Histone	3 → 102	Core histone H2A/H2B/H3/H4	Domain

• Sequence:

  MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
  GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
  KYTSSK

• Sequence length: 126

Pathways

KEGG Pathway	Reactome Pathway
Neutrophil extracellular trap formation	Recognition and association of DNA glycosylase with site containing an affected purine
Alcoholism	Cleavage of the damaged purine
Viral carcinogenesis	Packaging Of Telomere Ends
Systemic lupus erythematosus	Formation of the beta-catenin:TCF transactivating complex
	PRC2 methylates histones and DNA
	Condensation of Prophase Chromosomes
	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	HDACs deacetylate histones
	HATs acetylate histones
	SIRT1 negatively regulates rRNA expression
	NoRC negatively regulates rRNA expression
	B-WICH complex positively regulates rRNA expression
	Transcriptional regulation by small RNAs
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	Ub-specific processing proteases
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Nonhomologous End-Joining (NHEJ)
	Processing of DNA double-strand break ends
	Deposition of new CENPA-containing nucleosomes at the centromere
	G2/M DNA damage checkpoint
	RNA Polymerase I Promoter Opening
	RNA Polymerase I Promoter Escape
	E3 ubiquitin ligases ubiquitinate target proteins
	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
	Estrogen-dependent gene expression
	HCMV Early Events
	HCMV Late Events
	Amyloid fiber formation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

H2BC1 34 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +22 more Related via 34 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H2BC5 34 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +22 more Related via 34 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H2BC3 34 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +22 more Related via 34 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H2BC8 34 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +22 more Related via 34 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H2BC13 34 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +22 more Related via 34 shared pathways including Neutrophil extracellular trap formation, Alcoholism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
H2BC1	0	[]	34	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Ub-specific processing proteases","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H2BC5	0	[]	34	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Ub-specific processing proteases","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H2BC3	0	[]	34	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Ub-specific processing proteases","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H2BC8	0	[]	34	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Ub-specific processing proteases","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]
H2BC13	0	[]	34	["Neutrophil extracellular trap formation","Alcoholism","Viral carcinogenesis","Systemic lupus erythematosus","Ub-specific processing proteases","Condensation of Prophase Chromosomes","Deposition of new CENPA-containing nucleosomes at the centromere","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","DNA Damage\/Telomere Stress Induced Senescence","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]	0	[]

Diseases Linked via Similar Genes

Duodenal ulcer Linked via 1 of 5 related genesH2BC5 Insomnia Linked via 1 of 5 related genesH2BC5 Prostate cancer Linked via 1 of 5 related genesH2BC5 Diabetes mellitus Linked via 1 of 5 related genesH2BC3 Juvenile arthritis Linked via 1 of 5 related genesH2BC8

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Duodenal ulcer	1	["H2BC5"]
Insomnia	1	["H2BC5"]
Prostate cancer	1	["H2BC5"]
Diabetes mellitus	1	["H2BC3"]
Juvenile arthritis	1	["H2BC8"]