H2AC18 (H2A clustered histone 18)

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Gene Gene information from NCBI Gene database.
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Entrez ID 8337
Gene name H2A clustered histone 18
Gene symbol H2AC18
Synonyms (NCBI Gene)
H2AH2A.2H2A/OH2A/qH2AC19H2AFOH2a-615HIST2H2AAHIST2H2AA3
Chromosome 1
Chromosome location 1q21.2
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
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GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IBA
GO:0000786 Component Nucleosome IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 31759698, 32296183
GO:0005634 Component Nucleus HDA 21630459
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
142720 4736 ENSG00000288825
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
ATP-dependent chromatin remodeling Recognition and association of DNA glycosylase with site containing an affected purine
Necroptosis Cleavage of the damaged purine
Neutrophil extracellular trap formation Packaging Of Telomere Ends
Alcoholism Formation of the beta-catenin:TCF transactivating complex
Systemic lupus erythematosus PRC2 methylates histones and DNA
  Condensation of Prophase Chromosomes
  Oxidative Stress Induced Senescence
  Senescence-Associated Secretory Phenotype (SASP)
  DNA Damage/Telomere Stress Induced Senescence
  HDACs deacetylate histones
  HATs acetylate histones
  RMTs methylate histone arginines
  SIRT1 negatively regulates rRNA expression
  NoRC negatively regulates rRNA expression
  B-WICH complex positively regulates rRNA expression
  Transcriptional regulation by small RNAs
  Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  UCH proteinases
  Ub-specific processing proteases
  Metalloprotease DUBs
  Deposition of new CENPA-containing nucleosomes at the centromere
  RNA Polymerase I Promoter Opening
  RNA Polymerase I Promoter Escape
  RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  Estrogen-dependent gene expression
  HCMV Early Events
  HCMV Late Events
  Amyloid fiber formation
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H2AC8 33 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence +21 more Related via 33 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC7 33 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence +21 more Related via 33 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC19 33 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence +21 more Related via 33 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC14 33 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence +21 more Related via 33 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC6 33 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence +21 more Related via 33 shared pathways including ATP-dependent chromatin remodeling, Necroptosis.
Insomnia Linked via 3 of 5 related genesH2AC8, H2AC7, H2AC6 Schizophrenia Linked via 2 of 5 related genesH2AC14, H2AC6 Juvenile arthritis Linked via 1 of 5 related genesH2AC8 Juvenile idiopathic arthritis Linked via 1 of 5 related genesH2AC8 Oligoarticular juvenile idiopathic arthritis Linked via 1 of 5 related genesH2AC8