H2AC17 (H2A clustered histone 17)

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Gene Gene information from NCBI Gene database.
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Entrez ID 8336
Gene name H2A clustered histone 17
Gene symbol H2AC17
Synonyms (NCBI Gene)
H2A.1H2A/nH2AC11H2AC13H2AC15H2AC16H2AFNHIST1H2AMdJ193B12.1
Chromosome 6
Chromosome location 6p22.1
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
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GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IBA
GO:0000786 Component Nucleosome IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 15161933, 18688256, 20618440, 21179169, 22194607, 25281266, 35390161
GO:0005634 Component Nucleus HDA 21630459
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
602796 4735 ENSG00000278677
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
ATP-dependent chromatin remodeling HDACs deacetylate histones
Necroptosis HATs acetylate histones
Neutrophil extracellular trap formation RMTs methylate histone arginines
Alcoholism UCH proteinases
Systemic lupus erythematosus Ub-specific processing proteases
  Metalloprotease DUBs
  HCMV Early Events
  HCMV Late Events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Multiple myeloma Likely pathogenic rs1581495906 RCV000984095
★★★★★
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
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H2AC1 13 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, HCMV Late Events, HCMV Early Events, RMTs methylate histone arginines, UCH proteinases, Metalloprotease DUBs, HDACs deacetylate histones +1 more Related via 13 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC21 13 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, HCMV Late Events, HCMV Early Events, RMTs methylate histone arginines, UCH proteinases, Metalloprotease DUBs, HDACs deacetylate histones +1 more Related via 13 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC13 13 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, HCMV Late Events, HCMV Early Events, RMTs methylate histone arginines, UCH proteinases, Metalloprotease DUBs, HDACs deacetylate histones +1 more Related via 13 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC15 13 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, HCMV Late Events, HCMV Early Events, RMTs methylate histone arginines, UCH proteinases, Metalloprotease DUBs, HDACs deacetylate histones +1 more Related via 13 shared pathways including ATP-dependent chromatin remodeling, Necroptosis. H2AC16 13 shared pathwaysATP-dependent chromatin remodeling, Necroptosis, Neutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, HCMV Late Events, HCMV Early Events, RMTs methylate histone arginines, UCH proteinases, Metalloprotease DUBs, HDACs deacetylate histones +1 more Related via 13 shared pathways including ATP-dependent chromatin remodeling, Necroptosis.
Major depressive disorder Linked via 2 of 5 related genesH2AC1, H2AC15 Breast cancer Linked via 1 of 5 related genesH2AC1 Coronary artery disease Linked via 1 of 5 related genesH2AC1 Neurotic disorder Linked via 1 of 5 related genesH2AC1 Bipolar disorder Linked via 1 of 5 related genesH2AC15