GTF2H2 (general transcription factor IIH subunit 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2966
• Gene name: General transcription factor IIH subunit 2
• Gene symbol: GTF2H2
• Synonyms (NCBI Gene): BTF2, BTF2 p44, BTF2P44, T-BTF2P44, TFIIH, p44
• Chromosome: 5
• Chromosome location: 5q13.2
• Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have

miRNA Show/Hide all (298)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023302	hsa-miR-122-5p	Microarray	17612493
MIRT028505	hsa-miR-30a-5p	Proteomics	18668040
MIRT042884	hsa-miR-324-3p	CLASH	23622248
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT677499	hsa-miR-562	HITS-CLIP	23824327
MIRT677498	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT677497	hsa-miR-5697	HITS-CLIP	23824327
MIRT677496	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT677495	hsa-miR-4673	HITS-CLIP	23824327
MIRT677494	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT677493	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677492	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677491	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677490	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677489	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677488	hsa-miR-1976	HITS-CLIP	23824327
MIRT677487	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677486	hsa-miR-3199	HITS-CLIP	23824327
MIRT677485	hsa-miR-8052	HITS-CLIP	23824327
MIRT677484	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677483	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677482	hsa-miR-4279	HITS-CLIP	23824327
MIRT677481	hsa-miR-5095	HITS-CLIP	23824327
MIRT1036962	hsa-miR-1224-3p	CLIP-seq
MIRT1036963	hsa-miR-125a-3p	CLIP-seq
MIRT1036964	hsa-miR-127-5p	CLIP-seq
MIRT1036965	hsa-miR-128	CLIP-seq
MIRT1036966	hsa-miR-1287	CLIP-seq
MIRT1036967	hsa-miR-144	CLIP-seq
MIRT1036968	hsa-miR-150	CLIP-seq
MIRT1036969	hsa-miR-186	CLIP-seq
MIRT1036970	hsa-miR-1913	CLIP-seq
MIRT1036971	hsa-miR-197	CLIP-seq
MIRT1036972	hsa-miR-217	CLIP-seq
MIRT1036973	hsa-miR-224	CLIP-seq
MIRT1036974	hsa-miR-27a	CLIP-seq
MIRT1036975	hsa-miR-27b	CLIP-seq
MIRT1036976	hsa-miR-3133	CLIP-seq
MIRT1036977	hsa-miR-3135b	CLIP-seq
MIRT1036978	hsa-miR-3147	CLIP-seq
MIRT1036979	hsa-miR-3187-3p	CLIP-seq
MIRT1036980	hsa-miR-362-5p	CLIP-seq
MIRT1036981	hsa-miR-3646	CLIP-seq
MIRT1036982	hsa-miR-3663-5p	CLIP-seq
MIRT1036983	hsa-miR-371b-5p	CLIP-seq
MIRT1036984	hsa-miR-3934	CLIP-seq
MIRT1036985	hsa-miR-4307	CLIP-seq
MIRT1036986	hsa-miR-4418	CLIP-seq
MIRT1036987	hsa-miR-4425	CLIP-seq
MIRT1036988	hsa-miR-4435	CLIP-seq
MIRT1036989	hsa-miR-4504	CLIP-seq
MIRT1036990	hsa-miR-4509	CLIP-seq
MIRT1036991	hsa-miR-450b-3p	CLIP-seq
MIRT1036992	hsa-miR-4652-3p	CLIP-seq
MIRT1036993	hsa-miR-4659a-3p	CLIP-seq
MIRT1036994	hsa-miR-4659b-3p	CLIP-seq
MIRT1036995	hsa-miR-4666-3p	CLIP-seq
MIRT1036996	hsa-miR-4677-3p	CLIP-seq
MIRT1036997	hsa-miR-4678	CLIP-seq
MIRT1036998	hsa-miR-4679	CLIP-seq
MIRT1036999	hsa-miR-4684-3p	CLIP-seq
MIRT1037000	hsa-miR-4698	CLIP-seq
MIRT1037001	hsa-miR-4701-5p	CLIP-seq
MIRT1037002	hsa-miR-4716-5p	CLIP-seq
MIRT1037003	hsa-miR-4719	CLIP-seq
MIRT1037004	hsa-miR-4724-3p	CLIP-seq
MIRT1037005	hsa-miR-4744	CLIP-seq
MIRT1037006	hsa-miR-4755-3p	CLIP-seq
MIRT1037007	hsa-miR-4766-3p	CLIP-seq
MIRT1037008	hsa-miR-4778-3p	CLIP-seq
MIRT1037009	hsa-miR-4781-3p	CLIP-seq
MIRT1037010	hsa-miR-4789-3p	CLIP-seq
MIRT1037011	hsa-miR-4799-5p	CLIP-seq
MIRT1037012	hsa-miR-500b	CLIP-seq
MIRT1037013	hsa-miR-501-5p	CLIP-seq
MIRT1037014	hsa-miR-509-3-5p	CLIP-seq
MIRT1037015	hsa-miR-509-5p	CLIP-seq
MIRT1037016	hsa-miR-5096	CLIP-seq
MIRT1037017	hsa-miR-513a-3p	CLIP-seq
MIRT1037018	hsa-miR-513a-5p	CLIP-seq
MIRT1037019	hsa-miR-518a-5p	CLIP-seq
MIRT1037020	hsa-miR-520g	CLIP-seq
MIRT1037021	hsa-miR-520h	CLIP-seq
MIRT1037022	hsa-miR-527	CLIP-seq
MIRT1037023	hsa-miR-542-3p	CLIP-seq
MIRT1037024	hsa-miR-548p	CLIP-seq
MIRT1037025	hsa-miR-548s	CLIP-seq
MIRT1037026	hsa-miR-549	CLIP-seq
MIRT1037027	hsa-miR-552	CLIP-seq
MIRT1037028	hsa-miR-556-3p	CLIP-seq
MIRT1037029	hsa-miR-561	CLIP-seq
MIRT1037030	hsa-miR-570	CLIP-seq
MIRT1037031	hsa-miR-588	CLIP-seq
MIRT1037032	hsa-miR-764	CLIP-seq
MIRT1037033	hsa-miR-769-3p	CLIP-seq
MIRT1037034	hsa-miR-888	CLIP-seq
MIRT1036962	hsa-miR-1224-3p	CLIP-seq
MIRT1036963	hsa-miR-125a-3p	CLIP-seq
MIRT1036965	hsa-miR-128	CLIP-seq
MIRT1036966	hsa-miR-1287	CLIP-seq
MIRT1036969	hsa-miR-186	CLIP-seq
MIRT1036970	hsa-miR-1913	CLIP-seq
MIRT1036971	hsa-miR-197	CLIP-seq
MIRT1036974	hsa-miR-27a	CLIP-seq
MIRT1036975	hsa-miR-27b	CLIP-seq
MIRT1036976	hsa-miR-3133	CLIP-seq
MIRT1036977	hsa-miR-3135b	CLIP-seq
MIRT1036979	hsa-miR-3187-3p	CLIP-seq
MIRT1036982	hsa-miR-3663-5p	CLIP-seq
MIRT1036984	hsa-miR-3934	CLIP-seq
MIRT1036988	hsa-miR-4435	CLIP-seq
MIRT1036989	hsa-miR-4504	CLIP-seq
MIRT1036990	hsa-miR-4509	CLIP-seq
MIRT1036992	hsa-miR-4652-3p	CLIP-seq
MIRT1036995	hsa-miR-4666-3p	CLIP-seq
MIRT1036996	hsa-miR-4677-3p	CLIP-seq
MIRT1036998	hsa-miR-4679	CLIP-seq
MIRT1036999	hsa-miR-4684-3p	CLIP-seq
MIRT1037001	hsa-miR-4701-5p	CLIP-seq
MIRT1037002	hsa-miR-4716-5p	CLIP-seq
MIRT1037003	hsa-miR-4719	CLIP-seq
MIRT1037005	hsa-miR-4744	CLIP-seq
MIRT1037006	hsa-miR-4755-3p	CLIP-seq
MIRT1037009	hsa-miR-4781-3p	CLIP-seq
MIRT1037010	hsa-miR-4789-3p	CLIP-seq
MIRT1037016	hsa-miR-5096	CLIP-seq
MIRT1037017	hsa-miR-513a-3p	CLIP-seq
MIRT1037018	hsa-miR-513a-5p	CLIP-seq
MIRT1037019	hsa-miR-518a-5p	CLIP-seq
MIRT1037022	hsa-miR-527	CLIP-seq
MIRT1037023	hsa-miR-542-3p	CLIP-seq
MIRT1037025	hsa-miR-548s	CLIP-seq
MIRT1037026	hsa-miR-549	CLIP-seq
MIRT1037031	hsa-miR-588	CLIP-seq
MIRT1037032	hsa-miR-764	CLIP-seq
MIRT1036962	hsa-miR-1224-3p	CLIP-seq
MIRT1036963	hsa-miR-125a-3p	CLIP-seq
MIRT1036968	hsa-miR-150	CLIP-seq
MIRT1036970	hsa-miR-1913	CLIP-seq
MIRT1036979	hsa-miR-3187-3p	CLIP-seq
MIRT1036982	hsa-miR-3663-5p	CLIP-seq
MIRT1036984	hsa-miR-3934	CLIP-seq
MIRT1036988	hsa-miR-4435	CLIP-seq
MIRT1036989	hsa-miR-4504	CLIP-seq
MIRT1036992	hsa-miR-4652-3p	CLIP-seq
MIRT1036996	hsa-miR-4677-3p	CLIP-seq
MIRT1036997	hsa-miR-4678	CLIP-seq
MIRT1036998	hsa-miR-4679	CLIP-seq
MIRT2240095	hsa-miR-4680-3p	CLIP-seq
MIRT1037001	hsa-miR-4701-5p	CLIP-seq
MIRT1037003	hsa-miR-4719	CLIP-seq
MIRT1037006	hsa-miR-4755-3p	CLIP-seq
MIRT1037008	hsa-miR-4778-3p	CLIP-seq
MIRT1037009	hsa-miR-4781-3p	CLIP-seq
MIRT1037017	hsa-miR-513a-3p	CLIP-seq
MIRT1037020	hsa-miR-520g	CLIP-seq
MIRT1037021	hsa-miR-520h	CLIP-seq
MIRT1037023	hsa-miR-542-3p	CLIP-seq
MIRT1037025	hsa-miR-548s	CLIP-seq
MIRT1037026	hsa-miR-549	CLIP-seq
MIRT1037031	hsa-miR-588	CLIP-seq
MIRT1037032	hsa-miR-764	CLIP-seq
MIRT1036962	hsa-miR-1224-3p	CLIP-seq
MIRT1036968	hsa-miR-150	CLIP-seq
MIRT1037020	hsa-miR-520g	CLIP-seq
MIRT1037021	hsa-miR-520h	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000438	Component	Core TFIIH complex portion of holo TFIIH complex	IDA	27193682
GO:0000439	Component	Transcription factor TFIIH core complex	IDA	11445587
GO:0000439	Component	Transcription factor TFIIH core complex	IEA
GO:0002031	Process	G protein-coupled receptor internalization	IMP	15775968
GO:0005515	Function	Protein binding	IPI	7664335, 8652557, 8692842, 11445587, 16669699, 17438371, 19172752, 19934020, 21988832, 26496610, 27193682, 28514442, 33961781
GO:0005634	Component	Nucleus	IDA	27193682
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IDA	27193682
GO:0005675	Component	Transcription factor TFIIH holo complex	IBA
GO:0005675	Component	Transcription factor TFIIH holo complex	IDA	9852112
GO:0006281	Process	DNA repair	IEA
GO:0006289	Process	Nucleotide-excision repair	IBA
GO:0006289	Process	Nucleotide-excision repair	IEA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	9852112, 27193682
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IDA	10924514
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009411	Process	Response to UV	TAS	8194529
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IDA	10924514, 27193682
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 601748
• HGNC: 4656
• e!Ensembl: ENSG00000145736

Protein

• UniProt ID: Q13888
• Protein name: General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)
• Protein function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA
• PDB: 1Z60 , 5IVW , 5IY6 , 5IY7 , 5IY8 , 5IY9 , 5O85 , 5OF4 , 6NMI , 6O9L , 6O9M , 6RO4 , 7AD8 , 7EGB , 7EGC , 7ENA , 7ENC , 7LBM , 7NVR , 7NVW , 7NVX , 7NVY , 7NVZ , 7NW0 , 8BVW , 8BYQ , 8EBS , 8EBT , 8EBU , 8EBV , 8EBW , 8EBX , 8EBY , 8GXQ , 8GXS , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR , 8WAS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04056	Ssl1	64 → 255	Ssl1-like	Family
  PF07975	C1_4	344 → 387	TFIIH C1-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with higher expression in skeletal muscle. {ECO:0000269|PubMed:9063743}.
• Sequence:

  MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
  LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
  SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
  NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
  ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
  LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
  AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV

• Sequence length: 395

Pathways

KEGG Pathway	Reactome Pathway
Basal transcription factors	Formation of RNA Pol II elongation complex
Nucleotide excision repair	Formation of the Early Elongation Complex
Viral carcinogenesis	Formation of Incision Complex in GG-NER
	Dual Incision in GG-NER
	RNA Polymerase II Pre-transcription Events
	Formation of TC-NER Pre-Incision Complex
	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	TP53 Regulates Transcription of DNA Repair Genes
	mRNA Capping
	RNA Polymerase I Transcription Initiation
	RNA Polymerase I Promoter Escape
	RNA Polymerase II Promoter Escape
	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
	RNA Polymerase I Transcription Termination
	RNA Polymerase II Transcription Initiation
	RNA Polymerase II Transcription Elongation
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	RNA Pol II CTD phosphorylation and interaction with CE

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GTF2H1 23 shared pathwaysBasal transcription factors, Nucleotide excision repair, Viral carcinogenesis, Formation of Incision Complex in GG-NER, Dual Incision in GG-NER, Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Formation of TC-NER Pre-Incision Complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Dual incision in TC-NER +11 more Related via 23 shared pathways including Basal transcription factors, Nucleotide excision repair. GTF2H3 23 shared pathwaysBasal transcription factors, Nucleotide excision repair, Viral carcinogenesis, Formation of Incision Complex in GG-NER, Dual Incision in GG-NER, Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Formation of TC-NER Pre-Incision Complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Dual incision in TC-NER +11 more Related via 23 shared pathways including Basal transcription factors, Nucleotide excision repair. GTF2H4 23 shared pathwaysBasal transcription factors, Nucleotide excision repair, Viral carcinogenesis, Formation of Incision Complex in GG-NER, Dual Incision in GG-NER, Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Formation of TC-NER Pre-Incision Complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Dual incision in TC-NER +11 more Related via 23 shared pathways including Basal transcription factors, Nucleotide excision repair. ERCC2 22 shared pathwaysBasal transcription factors, Nucleotide excision repair, Formation of Incision Complex in GG-NER, Dual Incision in GG-NER, Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Formation of TC-NER Pre-Incision Complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER +10 more Related via 22 shared pathways including Basal transcription factors, Nucleotide excision repair. ERCC3 22 shared pathwaysBasal transcription factors, Nucleotide excision repair, Formation of Incision Complex in GG-NER, Dual Incision in GG-NER, Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Formation of TC-NER Pre-Incision Complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER +10 more Related via 22 shared pathways including Basal transcription factors, Nucleotide excision repair.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GTF2H1	0	[]	23	["Basal transcription factors","Nucleotide excision repair","Viral carcinogenesis","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER"]	0	[]
GTF2H3	0	[]	23	["Basal transcription factors","Nucleotide excision repair","Viral carcinogenesis","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER"]	0	[]
GTF2H4	0	[]	23	["Basal transcription factors","Nucleotide excision repair","Viral carcinogenesis","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER"]	0	[]
ERCC2	0	[]	22	["Basal transcription factors","Nucleotide excision repair","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER"]	0	[]
ERCC3	0	[]	22	["Basal transcription factors","Nucleotide excision repair","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 3 of 5 related genesGTF2H1, GTF2H3, ERCC2 Squamous cell carcinoma Linked via 2 of 5 related genesGTF2H4, ERCC2 Trichothiodystrophy Linked via 2 of 5 related genesERCC2, ERCC3 Xeroderma pigmentosum Linked via 2 of 5 related genesERCC2, ERCC3 Xeroderma pigmentosum-cockayne syndrome Linked via 2 of 5 related genesERCC2, ERCC3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	3	["GTF2H1","GTF2H3","ERCC2"]
Squamous cell carcinoma	2	["GTF2H4","ERCC2"]
Trichothiodystrophy	2	["ERCC2","ERCC3"]
Xeroderma pigmentosum	2	["ERCC2","ERCC3"]
Xeroderma pigmentosum-cockayne syndrome	2	["ERCC2","ERCC3"]