Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	80852
Gene name	Glutamate receptor interacting protein 2
Gene symbol	GRIP2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p25.1

174 Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019003	hsa-miR-335-5p	Microarray	18185580
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT1034765	hsa-miR-1299	CLIP-seq
MIRT1034766	hsa-miR-1301	CLIP-seq
MIRT1034767	hsa-miR-136	CLIP-seq
MIRT1034768	hsa-miR-149	CLIP-seq
MIRT1034769	hsa-miR-1915	CLIP-seq
MIRT1034770	hsa-miR-2355-5p	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT1034773	hsa-miR-3173-3p	CLIP-seq
MIRT1034774	hsa-miR-326	CLIP-seq
MIRT1034775	hsa-miR-330-5p	CLIP-seq
MIRT1034776	hsa-miR-331-5p	CLIP-seq
MIRT1034777	hsa-miR-3612	CLIP-seq
MIRT1034778	hsa-miR-3661	CLIP-seq
MIRT1034779	hsa-miR-3679-3p	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT1034782	hsa-miR-378	CLIP-seq
MIRT1034783	hsa-miR-378b	CLIP-seq
MIRT1034784	hsa-miR-378c	CLIP-seq
MIRT1034785	hsa-miR-378d	CLIP-seq
MIRT1034786	hsa-miR-378e	CLIP-seq
MIRT1034787	hsa-miR-378f	CLIP-seq
MIRT1034788	hsa-miR-378h	CLIP-seq
MIRT1034789	hsa-miR-378i	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034791	hsa-miR-422a	CLIP-seq
MIRT1034792	hsa-miR-4264	CLIP-seq
MIRT1034793	hsa-miR-4267	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1034795	hsa-miR-4305	CLIP-seq
MIRT1034796	hsa-miR-4328	CLIP-seq
MIRT1034797	hsa-miR-4443	CLIP-seq
MIRT1034798	hsa-miR-4446-5p	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT1034800	hsa-miR-4638-3p	CLIP-seq
MIRT1034801	hsa-miR-4639-3p	CLIP-seq
MIRT1034802	hsa-miR-4660	CLIP-seq
MIRT1034803	hsa-miR-4678	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT1034805	hsa-miR-4695-5p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034807	hsa-miR-4726-3p	CLIP-seq
MIRT1034808	hsa-miR-4729	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT1034810	hsa-miR-4758-3p	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT1034812	hsa-miR-4797-3p	CLIP-seq
MIRT1034813	hsa-miR-4802-5p	CLIP-seq
MIRT1034814	hsa-miR-483-3p	CLIP-seq
MIRT1034815	hsa-miR-485-5p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT1034817	hsa-miR-502-5p	CLIP-seq
MIRT1034818	hsa-miR-5047	CLIP-seq
MIRT1034819	hsa-miR-508-5p	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT1034822	hsa-miR-548m	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034824	hsa-miR-631	CLIP-seq
MIRT1034825	hsa-miR-650	CLIP-seq
MIRT1034826	hsa-miR-769-5p	CLIP-seq
MIRT1034827	hsa-miR-875-3p	CLIP-seq
MIRT1034828	hsa-miR-877	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006856	hsa-miR-1178	CLIP-seq
MIRT2006857	hsa-miR-1302	CLIP-seq
MIRT2006858	hsa-miR-147	CLIP-seq
MIRT2006859	hsa-miR-3138	CLIP-seq
MIRT1034774	hsa-miR-326	CLIP-seq
MIRT1034775	hsa-miR-330-5p	CLIP-seq
MIRT1034778	hsa-miR-3661	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT2006860	hsa-miR-3907	CLIP-seq
MIRT2006861	hsa-miR-3911	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT2006862	hsa-miR-4298	CLIP-seq
MIRT2006863	hsa-miR-4436b-3p	CLIP-seq
MIRT1034801	hsa-miR-4639-3p	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT2006864	hsa-miR-4685-5p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006865	hsa-miR-4736	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT2006866	hsa-miR-4800-5p	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034824	hsa-miR-631	CLIP-seq
MIRT2006867	hsa-miR-635	CLIP-seq
MIRT2006868	hsa-miR-644	CLIP-seq
MIRT1034826	hsa-miR-769-5p	CLIP-seq
MIRT2239345	hsa-miR-1207-5p	CLIP-seq
MIRT2239346	hsa-miR-1238	CLIP-seq
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2239348	hsa-miR-3121-5p	CLIP-seq
MIRT2239349	hsa-miR-3143	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2006860	hsa-miR-3907	CLIP-seq
MIRT2239351	hsa-miR-4325	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT2239352	hsa-miR-4661-5p	CLIP-seq
MIRT2006864	hsa-miR-4685-5p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2239353	hsa-miR-4763-3p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT2239354	hsa-miR-507	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq
MIRT2239356	hsa-miR-550a	CLIP-seq
MIRT2239357	hsa-miR-557	CLIP-seq
MIRT2239358	hsa-miR-671-5p	CLIP-seq
MIRT2388782	hsa-miR-1236	CLIP-seq
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT2006858	hsa-miR-147	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT2006859	hsa-miR-3138	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT2006861	hsa-miR-3911	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006866	hsa-miR-4800-5p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT2006867	hsa-miR-635	CLIP-seq
MIRT2006868	hsa-miR-644	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2450791	hsa-miR-186	CLIP-seq
MIRT2450792	hsa-miR-3154	CLIP-seq
MIRT2450793	hsa-miR-3656	CLIP-seq
MIRT2006863	hsa-miR-4436b-3p	CLIP-seq
MIRT2450794	hsa-miR-4728-3p	CLIP-seq
MIRT2543175	hsa-miR-1307	CLIP-seq
MIRT2543176	hsa-miR-1324	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2543177	hsa-miR-3183	CLIP-seq
MIRT2543178	hsa-miR-361-3p	CLIP-seq
MIRT2543179	hsa-miR-3615	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2543180	hsa-miR-3943	CLIP-seq
MIRT2543181	hsa-miR-4279	CLIP-seq
MIRT2543182	hsa-miR-4638-5p	CLIP-seq
MIRT2543183	hsa-miR-4650-5p	CLIP-seq
MIRT2543184	hsa-miR-4723-3p	CLIP-seq
MIRT2543185	hsa-miR-4757-5p	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq
MIRT2543176	hsa-miR-1324	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq

11 Show/Hide all (11)

GO ID	Ontology	Definition	Evidence
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007219	Process	Notch signaling pathway	IEA
GO:0014824	Process	Artery smooth muscle contraction	IEA
GO:0016020	Component	Membrane	IEA
GO:0045777	Process	Positive regulation of blood pressure	IEA
GO:0098887	Process	Neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA
GO:0098887	Process	Neurotransmitter receptor transport, endosome to postsynaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099003	Process	Vesicle-mediated transport in synapse	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9C0E4

Protein name

Glutamate receptor-interacting protein 2 (GRIP-2)

Protein function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

PDB

1V62 , 1X5R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	656 → 735	PDZ domain	Domain
PF00595	PDZ	48 → 128	PDZ domain	Domain
PF00595	PDZ	557 → 638	PDZ domain	Domain
PF00595	PDZ	146 → 231	PDZ domain	Domain
PF00595	PDZ	249 → 329	PDZ domain	Domain
PF00595	PDZ	941 → 1020	PDZ domain	Domain
PF17820	PDZ_6	486 → 542	PDZ domain	Domain

Sequence

MLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLG
LTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVG
ERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTY
VRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTV
ANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSI
DGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVP
SCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRT
TMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATET
LSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE
VEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTL
EPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELK
RYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAI
HLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSV
DSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPA
DESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGT
VQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDG
LLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIIS
RKPHTAHSSRAPRSPGPSSPRML

Sequence length

1043

Interactions

View interactions

Reactome Pathway
Trafficking of GluR2-containing AMPA receptors

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CARCINOMA	—	GWAS catalog	34407845	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	34407845	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	38317187	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	34407845	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	35257412	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32529991	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GRIP2 (glutamate receptor interacting protein 2)

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