GREP1 (glycine rich extracellular protein 1)

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Gene Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 283875
• Gene name: Glycine rich extracellular protein 1
• Gene symbol: GREP1
• Synonyms (NCBI Gene): G029442, LA16c-380H5.1, LA16c-380H5.3, LINC00514
• Chromosome: 16
• Chromosome location: 16p13.3

Other IDs

• MIM: 621298
• HGNC: 27549
• e!Ensembl: ENSG00000262152

Protein

• UniProt ID: A0A0J9YXV3
• Protein name: Glycine-rich extracellular protein 1 (Long intergenic non-protein coding RNA 514)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BILE DUCT DISORDER	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	34652879	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE CERVICAL NEOPLASMS	—	CTD	34652879	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34825738	Stimulate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	34533201	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	34825738	Stimulate	★☆☆☆☆ Found in Text Mining only
Hepatitis B Chronic	Hepatitis b	Pubtator	34825738	Stimulate	★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	34825738	Stimulate	★☆☆☆☆ Found in Text Mining only
Liver Diseases	Liver disease	Pubtator	34825738	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	34533201	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30553447		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	30553447		★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	36193506	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33888645	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NPM2 2 shared diseasesBile duct disorder, Cholelithiasis 2 shared evidence sourcesGWAS catalog (Bile duct disorder), GWAS catalog (Cholelithiasis) Related via 2 shared diseases including Bile duct disorder, Cholelithiasis — evidence mostly GWAS catalog. PKMYT1 2 shared diseasesBile duct disorder, Cholelithiasis 2 shared evidence sourcesGWAS catalog (Bile duct disorder), GWAS catalog (Cholelithiasis) Related via 2 shared diseases including Bile duct disorder, Cholelithiasis — evidence mostly GWAS catalog. ADCY9 2 shared diseasesBile duct disorder, Cholelithiasis 2 shared evidence sourcesGWAS catalog (Bile duct disorder), GWAS catalog (Cholelithiasis) Related via 2 shared diseases including Bile duct disorder, Cholelithiasis — evidence mostly GWAS catalog. APOBEC3B 1 shared diseaseUterine neoplasms 2 shared evidence sourcesCTD (Squamous cell carcinoma), CTD (Uterine neoplasms) Related via 1 shared disease including Uterine neoplasms — evidence mostly CTD. MAML3 2 shared diseasesBile duct disorder, Cholelithiasis 2 shared evidence sourcesGWAS catalog (Bile duct disorder), GWAS catalog (Cholelithiasis) Related via 2 shared diseases including Bile duct disorder, Cholelithiasis — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NPM2	2	["Bile duct disorder","Cholelithiasis"]	0	[]	2	["GWAS catalog (Bile duct disorder)","GWAS catalog (Cholelithiasis)"]
PKMYT1	2	["Bile duct disorder","Cholelithiasis"]	0	[]	2	["GWAS catalog (Bile duct disorder)","GWAS catalog (Cholelithiasis)"]
ADCY9	2	["Bile duct disorder","Cholelithiasis"]	0	[]	2	["GWAS catalog (Bile duct disorder)","GWAS catalog (Cholelithiasis)"]
APOBEC3B	1	["Uterine neoplasms"]	0	[]	2	["CTD (Squamous cell carcinoma)","CTD (Uterine neoplasms)"]
MAML3	2	["Bile duct disorder","Cholelithiasis"]	0	[]	2	["GWAS catalog (Bile duct disorder)","GWAS catalog (Cholelithiasis)"]

Diseases Linked via Similar Genes

Metabolic syndrome Linked via 3 of 5 related genesPKMYT1, ADCY9, MAML3 Diabetes mellitus type 2 Linked via 3 of 5 related genesPKMYT1, ADCY9, MAML3 Obesity Linked via 2 of 5 related genesNPM2, ADCY9 Asthma Linked via 2 of 5 related genesADCY9, MAML3 Diverticular disease Linked via 2 of 5 related genesADCY9, MAML3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Metabolic syndrome	3	["PKMYT1","ADCY9","MAML3"]
Diabetes mellitus type 2	3	["PKMYT1","ADCY9","MAML3"]
Obesity	2	["NPM2","ADCY9"]
Asthma	2	["ADCY9","MAML3"]
Diverticular disease	2	["ADCY9","MAML3"]