Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51764
Gene name	G protein subunit gamma 13
Gene symbol	GNG13
Synonyms (NCBI Gene)	G(gamma)13HG3Jh2-35
Chromosome	16
Chromosome location	16p13.3
Summary	Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, r

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miRTarBase ID	miRNA	Experiments	Reference
MIRT054515	hsa-miR-513a-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT054516	hsa-miR-513b-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT054517	hsa-miR-513c-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT1024395	hsa-miR-122	CLIP-seq
MIRT1024396	hsa-miR-27a	CLIP-seq
MIRT1024397	hsa-miR-27b	CLIP-seq
MIRT1024398	hsa-miR-3151	CLIP-seq
MIRT1024399	hsa-miR-3170	CLIP-seq
MIRT1024400	hsa-miR-34b	CLIP-seq
MIRT1024401	hsa-miR-3650	CLIP-seq
MIRT1024402	hsa-miR-4433	CLIP-seq
MIRT1024403	hsa-miR-4481	CLIP-seq
MIRT1024404	hsa-miR-4494	CLIP-seq
MIRT1024405	hsa-miR-4640-5p	CLIP-seq
MIRT1024406	hsa-miR-4726-5p	CLIP-seq
MIRT1024407	hsa-miR-4745-5p	CLIP-seq
MIRT1024408	hsa-miR-4755-3p	CLIP-seq
MIRT1024409	hsa-miR-4758-5p	CLIP-seq
MIRT1024410	hsa-miR-541	CLIP-seq
MIRT1024411	hsa-miR-654-5p	CLIP-seq
MIRT1024412	hsa-miR-665	CLIP-seq
MIRT2003844	hsa-miR-1228	CLIP-seq
MIRT2003845	hsa-miR-142-5p	CLIP-seq
MIRT2003846	hsa-miR-224	CLIP-seq
MIRT2003847	hsa-miR-340	CLIP-seq
MIRT1024404	hsa-miR-4494	CLIP-seq
MIRT1024398	hsa-miR-3151	CLIP-seq
MIRT1024401	hsa-miR-3650	CLIP-seq
MIRT2236571	hsa-miR-3675-5p	CLIP-seq
MIRT2236572	hsa-miR-4283	CLIP-seq
MIRT2236573	hsa-miR-4284	CLIP-seq
MIRT2236574	hsa-miR-4437	CLIP-seq
MIRT1024403	hsa-miR-4481	CLIP-seq
MIRT2236575	hsa-miR-4489	CLIP-seq
MIRT2236576	hsa-miR-4492	CLIP-seq
MIRT2236577	hsa-miR-4498	CLIP-seq
MIRT2236578	hsa-miR-4505	CLIP-seq
MIRT1024407	hsa-miR-4745-5p	CLIP-seq
MIRT1024409	hsa-miR-4758-5p	CLIP-seq
MIRT2236579	hsa-miR-600	CLIP-seq
MIRT2236580	hsa-miR-762	CLIP-seq
MIRT1024398	hsa-miR-3151	CLIP-seq
MIRT2236572	hsa-miR-4283	CLIP-seq
MIRT2236573	hsa-miR-4284	CLIP-seq
MIRT1024402	hsa-miR-4433	CLIP-seq
MIRT2236574	hsa-miR-4437	CLIP-seq
MIRT1024403	hsa-miR-4481	CLIP-seq
MIRT2236575	hsa-miR-4489	CLIP-seq
MIRT1024405	hsa-miR-4640-5p	CLIP-seq
MIRT1024406	hsa-miR-4726-5p	CLIP-seq
MIRT1024407	hsa-miR-4745-5p	CLIP-seq
MIRT1024409	hsa-miR-4758-5p	CLIP-seq
MIRT1024412	hsa-miR-665	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031681	Function	G-protein beta-subunit binding	IBA
GO:0031681	Function	G-protein beta-subunit binding	IEA
GO:0031681	Function	G-protein beta-subunit binding	IPI	12606627
GO:0045202	Component	Synapse	IEA
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050909	Process	Sensory perception of taste	IEA

MIM	HGNC	e!Ensembl
607298	14131	ENSG00000127588

Q9P2W3

Protein name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Protein function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00631	G-gamma	3 → 67	GGL domain	Domain

Sequence

MEEWDVPQMKKEVESLKYQLAFQREMASKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVE
KGKCTIL

Sequence length

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ras signaling pathway	Activation of G protein gated Potassium channels
Chemokine signaling pathway	Glucagon signaling in metabolic regulation
Hormone signaling	G-protein activation
PI3K-Akt signaling pathway	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Apelin signaling pathway	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Circadian entrainment	ADP signalling through P2Y purinoceptor 12
Retrograde endocannabinoid signaling	G beta:gamma signalling through PI3Kgamma
Glutamatergic synapse	Prostacyclin signalling through prostacyclin receptor
Cholinergic synapse	Adrenaline,noradrenaline inhibits insulin secretion
Serotonergic synapse	Ca2+ pathway
GABAergic synapse	G alpha (q) signalling events
Dopaminergic synapse	G alpha (12/13) signalling events
Olfactory transduction	G beta:gamma signalling through PLC beta
Taste transduction	G alpha (s) signalling events
Relaxin signaling pathway	ADP signalling through P2Y purinoceptor 1
Morphine addiction	G alpha (i) signalling events
Alcoholism	G alpha (z) signalling events
Human cytomegalovirus infection	Glucagon-type ligand receptors
Kaposi sarcoma-associated herpesvirus infection	Thromboxane signalling through TP receptor
Human immunodeficiency virus 1 infection	Vasopressin regulates renal water homeostasis via Aquaporins
Pathways in cancer	Thrombin signalling through proteinase activated receptors (PARs)
	Presynaptic function of Kainate receptors
	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
	G beta:gamma signalling through BTK
	G beta:gamma signalling through CDC42
	Extra-nuclear estrogen signaling
	ADORA2B mediated anti-inflammatory cytokines production
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
GNB3	[]	46	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Taste transduction"]	[]
GNB2	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG3	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG4	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG5	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]

GNG13 (G protein subunit gamma 13)

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