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Gene Gene information from NCBI Gene database.
Entrez ID 23062
Gene name Golgi associated, gamma adaptin ear containing, ARF binding protein 2
Gene symbol GGA2
Synonyms (NCBI Gene)
VEAR
Chromosome 16
Chromosome location 16p12.2
Summary This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These prot
miRNA miRNA information provided by mirtarbase database.
1147 Show/Hide all (1147)
miRTarBase ID miRNA Experiments Reference
MIRT022714 hsa-miR-124-3p Microarray 18668037
MIRT030525 hsa-miR-24-3p Microarray 19296935
MIRT050070 hsa-miR-26a-5p CLASH 23622248
MIRT049383 hsa-miR-92a-3p CLASH 23622248
MIRT523578 hsa-miR-4252 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28 Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11821067, 12429846, 12505986, 14638859, 16189514, 19478182, 25416956, 25910212, 26053850, 27901063, 28514442, 30679749, 32296183, 32814053, 33961781
GO:0005768 Component Endosome IEA
GO:0005794 Component Golgi apparatus IDA
GO:0005794 Component Golgi apparatus IEA
GO:0005802 Component Trans-Golgi network IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606005 16064 ENSG00000103365
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UJY4
Protein name ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Protein function Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic aci
PDB 1MHQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00790 VHS 20 → 159 VHS domain Domain
PF02883 Alpha_adaptinC2 487 → 605 Adaptin C-terminal domain Domain
PF03127 GAT 239 → 316 GAT domain Domain
PF18308 GGA_N-GAT 185 → 224 GGA N-GAT domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed.
Sequence
Sequence length 613
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Lysosome TBC/RABGAPs
  Amyloid fiber formation