GABRE (gamma-aminobutyric acid type A receptor subunit epsilon)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2564
• Gene name: Gamma-aminobutyric acid type A receptor subunit epsilon
• Gene symbol: GABRE
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xq28
• Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the centr

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs998297769	G>T	Pathogenic	Coding sequence variant, intron variant, stop gained, upstream transcript variant, genic upstream transcript variant

miRNA Show/Hide all (271)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027440	hsa-miR-98-5p	Microarray	19088304
MIRT028956	hsa-miR-26b-5p	Microarray	19088304
MIRT1010005	hsa-miR-1250	CLIP-seq
MIRT1010006	hsa-miR-1304	CLIP-seq
MIRT1010007	hsa-miR-146a	CLIP-seq
MIRT1010008	hsa-miR-146b-5p	CLIP-seq
MIRT1010009	hsa-miR-185	CLIP-seq
MIRT1010010	hsa-miR-219-5p	CLIP-seq
MIRT1010011	hsa-miR-224	CLIP-seq
MIRT1010012	hsa-miR-2467-5p	CLIP-seq
MIRT1010013	hsa-miR-3153	CLIP-seq
MIRT1010014	hsa-miR-3188	CLIP-seq
MIRT1010015	hsa-miR-3925-5p	CLIP-seq
MIRT1010016	hsa-miR-3929	CLIP-seq
MIRT1010017	hsa-miR-3936	CLIP-seq
MIRT1010018	hsa-miR-3975	CLIP-seq
MIRT1010019	hsa-miR-4270	CLIP-seq
MIRT1010020	hsa-miR-4271	CLIP-seq
MIRT1010021	hsa-miR-4306	CLIP-seq
MIRT1010022	hsa-miR-4325	CLIP-seq
MIRT1010023	hsa-miR-4419b	CLIP-seq
MIRT1010024	hsa-miR-4441	CLIP-seq
MIRT1010025	hsa-miR-4445	CLIP-seq
MIRT1010026	hsa-miR-4478	CLIP-seq
MIRT1010027	hsa-miR-4644	CLIP-seq
MIRT1010028	hsa-miR-4646-5p	CLIP-seq
MIRT1010029	hsa-miR-4649-3p	CLIP-seq
MIRT1010030	hsa-miR-4668-5p	CLIP-seq
MIRT1010031	hsa-miR-4690-5p	CLIP-seq
MIRT1010032	hsa-miR-4725-3p	CLIP-seq
MIRT1010033	hsa-miR-4782-3p	CLIP-seq
MIRT1010034	hsa-miR-485-5p	CLIP-seq
MIRT1010035	hsa-miR-508-3p	CLIP-seq
MIRT1999174	hsa-miR-15a	CLIP-seq
MIRT1999175	hsa-miR-15b	CLIP-seq
MIRT1999176	hsa-miR-16	CLIP-seq
MIRT1999177	hsa-miR-195	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT1999180	hsa-miR-3679-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT1999182	hsa-miR-424	CLIP-seq
MIRT1999183	hsa-miR-4419a	CLIP-seq
MIRT1999184	hsa-miR-4428	CLIP-seq
MIRT1999185	hsa-miR-4510	CLIP-seq
MIRT1999186	hsa-miR-497	CLIP-seq
MIRT1999174	hsa-miR-15a	CLIP-seq
MIRT1999175	hsa-miR-15b	CLIP-seq
MIRT1999176	hsa-miR-16	CLIP-seq
MIRT1999177	hsa-miR-195	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT2232866	hsa-miR-3121-3p	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT2232867	hsa-miR-328	CLIP-seq
MIRT1999180	hsa-miR-3679-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT1999182	hsa-miR-424	CLIP-seq
MIRT1999183	hsa-miR-4419a	CLIP-seq
MIRT1999184	hsa-miR-4428	CLIP-seq
MIRT1999185	hsa-miR-4510	CLIP-seq
MIRT1999186	hsa-miR-497	CLIP-seq
MIRT2232868	hsa-miR-578	CLIP-seq
MIRT1999174	hsa-miR-15a	CLIP-seq
MIRT1999175	hsa-miR-15b	CLIP-seq
MIRT1999176	hsa-miR-16	CLIP-seq
MIRT1999177	hsa-miR-195	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT1999180	hsa-miR-3679-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT1999182	hsa-miR-424	CLIP-seq
MIRT1999183	hsa-miR-4419a	CLIP-seq
MIRT1999184	hsa-miR-4428	CLIP-seq
MIRT1999185	hsa-miR-4510	CLIP-seq
MIRT1999186	hsa-miR-497	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT1999180	hsa-miR-3679-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT2536463	hsa-miR-106a	CLIP-seq
MIRT2536464	hsa-miR-106b	CLIP-seq
MIRT2536465	hsa-miR-1184	CLIP-seq
MIRT2536466	hsa-miR-1205	CLIP-seq
MIRT2536467	hsa-miR-1236	CLIP-seq
MIRT2536468	hsa-miR-1255a	CLIP-seq
MIRT2536469	hsa-miR-1255b	CLIP-seq
MIRT2536470	hsa-miR-1256	CLIP-seq
MIRT2536471	hsa-miR-1275	CLIP-seq
MIRT2536472	hsa-miR-1276	CLIP-seq
MIRT2536473	hsa-miR-1298	CLIP-seq
MIRT2536474	hsa-miR-130a	CLIP-seq
MIRT2536475	hsa-miR-130b	CLIP-seq
MIRT2536476	hsa-miR-145	CLIP-seq
MIRT1010007	hsa-miR-146a	CLIP-seq
MIRT1010008	hsa-miR-146b-5p	CLIP-seq
MIRT1999174	hsa-miR-15a	CLIP-seq
MIRT1999175	hsa-miR-15b	CLIP-seq
MIRT1999176	hsa-miR-16	CLIP-seq
MIRT2536477	hsa-miR-17	CLIP-seq
MIRT1010009	hsa-miR-185	CLIP-seq
MIRT2536478	hsa-miR-1913	CLIP-seq
MIRT1999177	hsa-miR-195	CLIP-seq
MIRT2536479	hsa-miR-1972	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT2536480	hsa-miR-199a-5p	CLIP-seq
MIRT2536481	hsa-miR-199b-5p	CLIP-seq
MIRT2536482	hsa-miR-20a	CLIP-seq
MIRT2536483	hsa-miR-20b	CLIP-seq
MIRT2536484	hsa-miR-219-2-3p	CLIP-seq
MIRT2536485	hsa-miR-2467-3p	CLIP-seq
MIRT2536486	hsa-miR-2964a-3p	CLIP-seq
MIRT2536487	hsa-miR-301a	CLIP-seq
MIRT2536488	hsa-miR-301b	CLIP-seq
MIRT2536489	hsa-miR-302a	CLIP-seq
MIRT2536490	hsa-miR-302b	CLIP-seq
MIRT2536491	hsa-miR-302c	CLIP-seq
MIRT2536492	hsa-miR-302d	CLIP-seq
MIRT2536493	hsa-miR-302e	CLIP-seq
MIRT2232866	hsa-miR-3121-3p	CLIP-seq
MIRT2536494	hsa-miR-3125	CLIP-seq
MIRT2536495	hsa-miR-3158-5p	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT2536496	hsa-miR-3166	CLIP-seq
MIRT2536497	hsa-miR-3179	CLIP-seq
MIRT2536498	hsa-miR-324-3p	CLIP-seq
MIRT2536499	hsa-miR-338-3p	CLIP-seq
MIRT2536500	hsa-miR-365	CLIP-seq
MIRT2536501	hsa-miR-3663-3p	CLIP-seq
MIRT2536502	hsa-miR-3666	CLIP-seq
MIRT2536503	hsa-miR-3678-3p	CLIP-seq
MIRT1999180	hsa-miR-3679-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT2536504	hsa-miR-372	CLIP-seq
MIRT2536505	hsa-miR-373	CLIP-seq
MIRT2536506	hsa-miR-377	CLIP-seq
MIRT2536507	hsa-miR-3916	CLIP-seq
MIRT2536508	hsa-miR-3919	CLIP-seq
MIRT1010017	hsa-miR-3936	CLIP-seq
MIRT1999182	hsa-miR-424	CLIP-seq
MIRT2536509	hsa-miR-4253	CLIP-seq
MIRT2536510	hsa-miR-4256	CLIP-seq
MIRT2536511	hsa-miR-4260	CLIP-seq
MIRT2536512	hsa-miR-4295	CLIP-seq
MIRT2536513	hsa-miR-4303	CLIP-seq
MIRT1010021	hsa-miR-4306	CLIP-seq
MIRT2536514	hsa-miR-4311	CLIP-seq
MIRT2536515	hsa-miR-4313	CLIP-seq
MIRT1999184	hsa-miR-4428	CLIP-seq
MIRT2536516	hsa-miR-4436b-5p	CLIP-seq
MIRT2536517	hsa-miR-4452	CLIP-seq
MIRT2536518	hsa-miR-4488	CLIP-seq
MIRT2536519	hsa-miR-4509	CLIP-seq
MIRT2536520	hsa-miR-4534	CLIP-seq
MIRT2536521	hsa-miR-454	CLIP-seq
MIRT1010027	hsa-miR-4644	CLIP-seq
MIRT2536522	hsa-miR-4650-5p	CLIP-seq
MIRT2536523	hsa-miR-4665-5p	CLIP-seq
MIRT2536524	hsa-miR-4671-3p	CLIP-seq
MIRT2536525	hsa-miR-4686	CLIP-seq
MIRT2536526	hsa-miR-4691-5p	CLIP-seq
MIRT2536527	hsa-miR-4697-5p	CLIP-seq
MIRT2536528	hsa-miR-4744	CLIP-seq
MIRT2536529	hsa-miR-4760-3p	CLIP-seq
MIRT2536530	hsa-miR-4761-3p	CLIP-seq
MIRT2536531	hsa-miR-4768-3p	CLIP-seq
MIRT2536532	hsa-miR-4771	CLIP-seq
MIRT2536533	hsa-miR-4776-3p	CLIP-seq
MIRT2536534	hsa-miR-4796-5p	CLIP-seq
MIRT2536535	hsa-miR-4803	CLIP-seq
MIRT2536536	hsa-miR-486-3p	CLIP-seq
MIRT1999186	hsa-miR-497	CLIP-seq
MIRT2536537	hsa-miR-519d	CLIP-seq
MIRT2536538	hsa-miR-520a-3p	CLIP-seq
MIRT2536539	hsa-miR-520b	CLIP-seq
MIRT2536540	hsa-miR-520c-3p	CLIP-seq
MIRT2536541	hsa-miR-520d-3p	CLIP-seq
MIRT2536542	hsa-miR-520e	CLIP-seq
MIRT2536543	hsa-miR-520f	CLIP-seq
MIRT2536544	hsa-miR-548n	CLIP-seq
MIRT2536545	hsa-miR-548t	CLIP-seq
MIRT2536546	hsa-miR-583	CLIP-seq
MIRT2536547	hsa-miR-589	CLIP-seq
MIRT2536548	hsa-miR-610	CLIP-seq
MIRT2536549	hsa-miR-622	CLIP-seq
MIRT2536550	hsa-miR-626	CLIP-seq
MIRT2536551	hsa-miR-635	CLIP-seq
MIRT2536552	hsa-miR-660	CLIP-seq
MIRT2536553	hsa-miR-664	CLIP-seq
MIRT2536554	hsa-miR-665	CLIP-seq
MIRT2536555	hsa-miR-922	CLIP-seq
MIRT2536556	hsa-miR-93	CLIP-seq
MIRT2536463	hsa-miR-106a	CLIP-seq
MIRT2536464	hsa-miR-106b	CLIP-seq
MIRT2536465	hsa-miR-1184	CLIP-seq
MIRT2536466	hsa-miR-1205	CLIP-seq
MIRT2536467	hsa-miR-1236	CLIP-seq
MIRT2536471	hsa-miR-1275	CLIP-seq
MIRT2536473	hsa-miR-1298	CLIP-seq
MIRT1010007	hsa-miR-146a	CLIP-seq
MIRT1010008	hsa-miR-146b-5p	CLIP-seq
MIRT1999174	hsa-miR-15a	CLIP-seq
MIRT1999175	hsa-miR-15b	CLIP-seq
MIRT1999176	hsa-miR-16	CLIP-seq
MIRT2536477	hsa-miR-17	CLIP-seq
MIRT1010009	hsa-miR-185	CLIP-seq
MIRT2536478	hsa-miR-1913	CLIP-seq
MIRT1999177	hsa-miR-195	CLIP-seq
MIRT2536479	hsa-miR-1972	CLIP-seq
MIRT1999178	hsa-miR-1976	CLIP-seq
MIRT2536480	hsa-miR-199a-5p	CLIP-seq
MIRT2536481	hsa-miR-199b-5p	CLIP-seq
MIRT2536482	hsa-miR-20a	CLIP-seq
MIRT2536483	hsa-miR-20b	CLIP-seq
MIRT2536489	hsa-miR-302a	CLIP-seq
MIRT2536490	hsa-miR-302b	CLIP-seq
MIRT2536491	hsa-miR-302c	CLIP-seq
MIRT2536492	hsa-miR-302d	CLIP-seq
MIRT2536493	hsa-miR-302e	CLIP-seq
MIRT2536494	hsa-miR-3125	CLIP-seq
MIRT2536495	hsa-miR-3158-5p	CLIP-seq
MIRT1999179	hsa-miR-3160-5p	CLIP-seq
MIRT2536498	hsa-miR-324-3p	CLIP-seq
MIRT2536499	hsa-miR-338-3p	CLIP-seq
MIRT2536500	hsa-miR-365	CLIP-seq
MIRT2536501	hsa-miR-3663-3p	CLIP-seq
MIRT1999181	hsa-miR-370	CLIP-seq
MIRT2536504	hsa-miR-372	CLIP-seq
MIRT2536505	hsa-miR-373	CLIP-seq
MIRT2536507	hsa-miR-3916	CLIP-seq
MIRT1999182	hsa-miR-424	CLIP-seq
MIRT2536509	hsa-miR-4253	CLIP-seq
MIRT2536510	hsa-miR-4256	CLIP-seq
MIRT2536511	hsa-miR-4260	CLIP-seq
MIRT2536513	hsa-miR-4303	CLIP-seq
MIRT1010021	hsa-miR-4306	CLIP-seq
MIRT2536515	hsa-miR-4313	CLIP-seq
MIRT1999184	hsa-miR-4428	CLIP-seq
MIRT2536516	hsa-miR-4436b-5p	CLIP-seq
MIRT2536518	hsa-miR-4488	CLIP-seq
MIRT2536519	hsa-miR-4509	CLIP-seq
MIRT1010027	hsa-miR-4644	CLIP-seq
MIRT2536522	hsa-miR-4650-5p	CLIP-seq
MIRT2536523	hsa-miR-4665-5p	CLIP-seq
MIRT2536525	hsa-miR-4686	CLIP-seq
MIRT2536526	hsa-miR-4691-5p	CLIP-seq
MIRT2536527	hsa-miR-4697-5p	CLIP-seq
MIRT2681334	hsa-miR-4755-3p	CLIP-seq
MIRT2536529	hsa-miR-4760-3p	CLIP-seq
MIRT2536531	hsa-miR-4768-3p	CLIP-seq
MIRT2536533	hsa-miR-4776-3p	CLIP-seq
MIRT2536534	hsa-miR-4796-5p	CLIP-seq
MIRT2536535	hsa-miR-4803	CLIP-seq
MIRT2536536	hsa-miR-486-3p	CLIP-seq
MIRT1999186	hsa-miR-497	CLIP-seq
MIRT2536537	hsa-miR-519d	CLIP-seq
MIRT2536538	hsa-miR-520a-3p	CLIP-seq
MIRT2536539	hsa-miR-520b	CLIP-seq
MIRT2536540	hsa-miR-520c-3p	CLIP-seq
MIRT2536541	hsa-miR-520d-3p	CLIP-seq
MIRT2536542	hsa-miR-520e	CLIP-seq
MIRT2536543	hsa-miR-520f	CLIP-seq
MIRT2536545	hsa-miR-548t	CLIP-seq
MIRT2536547	hsa-miR-589	CLIP-seq
MIRT2536548	hsa-miR-610	CLIP-seq
MIRT2536549	hsa-miR-622	CLIP-seq
MIRT2536550	hsa-miR-626	CLIP-seq
MIRT2536551	hsa-miR-635	CLIP-seq
MIRT2536553	hsa-miR-664	CLIP-seq
MIRT2536554	hsa-miR-665	CLIP-seq
MIRT2536555	hsa-miR-922	CLIP-seq
MIRT2536556	hsa-miR-93	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	IDA	9882711, 16412217
GO:0004890	Function	GABA-A receptor activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IBA
GO:0008503	Function	Benzodiazepine receptor activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0022824	Function	Transmitter-gated monoatomic ion channel activity	IEA
GO:0022851	Function	GABA-gated chloride ion channel activity	IBA
GO:0022851	Function	GABA-gated chloride ion channel activity	IDA	9039914, 9882711, 16412217
GO:0032590	Component	Dendrite membrane	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	IBA
GO:0098794	Component	Postsynapse	IBA
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902711	Component	GABA-A receptor complex	IBA
GO:1902711	Component	GABA-A receptor complex	IDA	9039914
GO:1904862	Process	Inhibitory synapse assembly	IBA
GO:2001226	Process	Negative regulation of chloride transport	IDA	9039914

Other IDs

• MIM: 300093
• HGNC: 4085
• e!Ensembl: ENSG00000102287

Protein

• UniProt ID: P78334
• Protein name: Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon)
• Protein function: Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) r
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02931	Neur_chan_LBD	71 → 277	Neurotransmitter-gated ion-channel ligand binding domain	Family
  PF02932	Neur_chan_memb	284 → 500	Neurotransmitter-gated ion-channel transmembrane region	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues (PubMed:9339354). Highest levels of expression in adult heart and placenta (PubMed:9084408, PubMed:9339354, PubMed:9882711). {ECO:0000269|PubMed:9084408, ECO:0000269|PubMed:9339354, ECO:0000269|PubMed:9882711}
• Sequence:

  MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
  TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
  IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
  GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
  KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
  IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
  LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
  PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
  DNYSRVVFPVTFFFFNVLYWLVCLNL

• Sequence length: 506

Pathways

KEGG Pathway

Neuroactive ligand-receptor interaction

Retrograde endocannabinoid signaling

GABAergic synapse

Morphine addiction

Nicotine addiction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Short stature	Pathogenic	rs998297769	RCV000736187	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
GABRE-related disorder	Uncertain significance; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GABRE-related epilepsy	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	32325953	Inhibit	★☆☆☆☆ Found in Text Mining only
Amyotrophic lateral sclerosis 1	Amyotrophic lateral sclerosis	Pubtator	32325953	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	28074849, 32588540	Associate	★☆☆☆☆ Found in Text Mining only
Essential Tremor	Tremor	BEFREE	21422964		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasm	Kidney Neoplasm	BEFREE	24440748		★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	21685710	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24737792		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24737792		★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	Pubtator	19087248, 34126933	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24737792		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	28084441	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GABRD 4 shared pathwaysRetrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Related via 4 shared pathways including Retrograde endocannabinoid signaling, GABAergic synapse. GABRG1 4 shared pathwaysRetrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Related via 4 shared pathways including Retrograde endocannabinoid signaling, GABAergic synapse. GABRP 4 shared pathwaysRetrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Related via 4 shared pathways including Retrograde endocannabinoid signaling, GABAergic synapse. GABRR3 4 shared pathwaysRetrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Related via 4 shared pathways including Retrograde endocannabinoid signaling, GABAergic synapse. GABRG2 4 shared pathwaysRetrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Related via 4 shared pathways including Retrograde endocannabinoid signaling, GABAergic synapse.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GABRD	0	[]	4	["Retrograde endocannabinoid signaling","GABAergic synapse","Morphine addiction","Nicotine addiction"]	0	[]
GABRG1	0	[]	4	["Retrograde endocannabinoid signaling","GABAergic synapse","Morphine addiction","Nicotine addiction"]	0	[]
GABRP	0	[]	4	["Retrograde endocannabinoid signaling","GABAergic synapse","Morphine addiction","Nicotine addiction"]	0	[]
GABRR3	0	[]	4	["Retrograde endocannabinoid signaling","GABAergic synapse","Morphine addiction","Nicotine addiction"]	0	[]
GABRG2	0	[]	4	["Retrograde endocannabinoid signaling","GABAergic synapse","Morphine addiction","Nicotine addiction"]	0	[]

Diseases Linked via Similar Genes

Epilepsy Linked via 3 of 5 related genesGABRD, GABRG1, GABRG2 Developmental and epileptic encephalopathy Linked via 3 of 5 related genesGABRD, GABRG1, GABRG2 Generalized epilepsy with febrile seizures plus Linked via 2 of 5 related genesGABRD, GABRG2 Schizophrenia Linked via 2 of 5 related genesGABRD, GABRG2 1p36 deletion syndrome Linked via 1 of 5 related genesGABRD

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Epilepsy	3	["GABRD","GABRG1","GABRG2"]
Developmental and epileptic encephalopathy	3	["GABRD","GABRG1","GABRG2"]
Generalized epilepsy with febrile seizures plus	2	["GABRD","GABRG2"]
Schizophrenia	2	["GABRD","GABRG2"]
1p36 deletion syndrome	1	["GABRD"]