FSTL3 (follistatin like 3)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10272
• Gene name: Follistatin like 3
• Gene symbol: FSTL3
• Synonyms (NCBI Gene): FLRG, FSRP
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019986	hsa-miR-375	Microarray	20215506
MIRT021408	hsa-miR-9-5p	Microarray	17612493
MIRT023194	hsa-miR-124-3p	Microarray	18668037
MIRT023374	hsa-miR-122-5p	Microarray	17612493
MIRT724993	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT724992	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT724991	hsa-miR-1910-5p	HITS-CLIP	19536157
MIRT724990	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT724989	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT724988	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724987	hsa-miR-4264	HITS-CLIP	19536157
MIRT724986	hsa-miR-4287	HITS-CLIP	19536157
MIRT724985	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT724984	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT724983	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT023194	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT712497	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT023194	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT712496	hsa-miR-3714	HITS-CLIP	19536157
MIRT712495	hsa-miR-3910	HITS-CLIP	19536157
MIRT712487	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT712494	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT712493	hsa-miR-4688	HITS-CLIP	19536157
MIRT712492	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT712490	hsa-miR-6085	HITS-CLIP	19536157
MIRT712491	hsa-miR-6813-5p	HITS-CLIP	19536157
MIRT712489	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT712488	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT712487	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT712486	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT712485	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT712484	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT712483	hsa-miR-612	HITS-CLIP	19536157
MIRT712482	hsa-miR-6860	HITS-CLIP	19536157
MIRT712481	hsa-miR-4486	HITS-CLIP	19536157
MIRT712480	hsa-miR-378g	HITS-CLIP	19536157
MIRT712479	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712478	hsa-miR-593-5p	HITS-CLIP	19536157
MIRT712477	hsa-miR-6789-5p	HITS-CLIP	19536157
MIRT712476	hsa-miR-4314	HITS-CLIP	19536157
MIRT712475	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT712474	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT724993	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT724992	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT724991	hsa-miR-1910-5p	HITS-CLIP	19536157
MIRT724990	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT724989	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT724988	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724987	hsa-miR-4264	HITS-CLIP	19536157
MIRT724986	hsa-miR-4287	HITS-CLIP	19536157
MIRT724985	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT724984	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT724983	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT023194	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT712497	hsa-miR-506-3p	HITS-CLIP	19536157
MIRT023194	hsa-miR-124-3p	HITS-CLIP	19536157
MIRT712496	hsa-miR-3714	HITS-CLIP	19536157
MIRT712495	hsa-miR-3910	HITS-CLIP	19536157
MIRT712487	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT712494	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT712493	hsa-miR-4688	HITS-CLIP	19536157
MIRT712492	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT712490	hsa-miR-6085	HITS-CLIP	19536157
MIRT712491	hsa-miR-6813-5p	HITS-CLIP	19536157
MIRT712489	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT712488	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT712487	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT712486	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT712485	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT712484	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT712483	hsa-miR-612	HITS-CLIP	19536157
MIRT712482	hsa-miR-6860	HITS-CLIP	19536157
MIRT712481	hsa-miR-4486	HITS-CLIP	19536157
MIRT712480	hsa-miR-378g	HITS-CLIP	19536157
MIRT712479	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT712478	hsa-miR-593-5p	HITS-CLIP	19536157
MIRT712477	hsa-miR-6789-5p	HITS-CLIP	19536157
MIRT712476	hsa-miR-4314	HITS-CLIP	19536157
MIRT712475	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT712474	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT1005556	hsa-miR-1207-5p	CLIP-seq
MIRT1005557	hsa-miR-1285	CLIP-seq
MIRT1005558	hsa-miR-1827	CLIP-seq
MIRT1005559	hsa-miR-296-5p	CLIP-seq
MIRT1005560	hsa-miR-3189-3p	CLIP-seq
MIRT1005561	hsa-miR-3918	CLIP-seq
MIRT1005562	hsa-miR-4316	CLIP-seq
MIRT1005563	hsa-miR-4710	CLIP-seq
MIRT1005564	hsa-miR-4763-3p	CLIP-seq
MIRT1005565	hsa-miR-4792	CLIP-seq
MIRT1005566	hsa-miR-502-5p	CLIP-seq
MIRT1005567	hsa-miR-940	CLIP-seq
MIRT1998011	hsa-miR-1254	CLIP-seq
MIRT1998012	hsa-miR-1910	CLIP-seq
MIRT1998013	hsa-miR-3116	CLIP-seq
MIRT1998014	hsa-miR-3652	CLIP-seq
MIRT1998015	hsa-miR-4430	CLIP-seq
MIRT1998016	hsa-miR-634	CLIP-seq
MIRT1998017	hsa-miR-661	CLIP-seq
MIRT1005556	hsa-miR-1207-5p	CLIP-seq
MIRT2231616	hsa-miR-1587	CLIP-seq
MIRT2231617	hsa-miR-4492	CLIP-seq
MIRT2231618	hsa-miR-4498	CLIP-seq
MIRT2231619	hsa-miR-4656	CLIP-seq
MIRT2231620	hsa-miR-4674	CLIP-seq
MIRT2231621	hsa-miR-4675	CLIP-seq
MIRT2231622	hsa-miR-4736	CLIP-seq
MIRT2231623	hsa-miR-4741	CLIP-seq
MIRT1005564	hsa-miR-4763-3p	CLIP-seq
MIRT2231624	hsa-miR-4790-3p	CLIP-seq
MIRT2231625	hsa-miR-635	CLIP-seq
MIRT2231626	hsa-miR-762	CLIP-seq
MIRT2388235	hsa-miR-3135b	CLIP-seq
MIRT2388236	hsa-miR-320e	CLIP-seq
MIRT1998014	hsa-miR-3652	CLIP-seq
MIRT2388237	hsa-miR-4271	CLIP-seq
MIRT1998015	hsa-miR-4430	CLIP-seq
MIRT2388238	hsa-miR-4725-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SMAD3	Unknown	11571638
SMAD4	Unknown	11571638

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0001968	Function	Fibronectin binding	IPI	16336961
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IDA	15451575
GO:0005515	Function	Protein binding	IPI	15574124, 17868029, 17878677
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	16150905
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	16150905
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	11948405
GO:0022409	Process	Positive regulation of cell-cell adhesion	IDA	16336961
GO:0030154	Process	Cell differentiation	IBA
GO:0030510	Process	Regulation of BMP signaling pathway	IBA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IDA	17878677
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0032926	Process	Negative regulation of activin receptor signaling pathway	IBA
GO:0032926	Process	Negative regulation of activin receptor signaling pathway	IDA	11948405, 12697670
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	15574124
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17868029
GO:0048185	Function	Activin binding	IBA
GO:0048185	Function	Activin binding	IEA
GO:0048185	Function	Activin binding	IPI	12697670
GO:0090101	Process	Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IDA	17878677

Other IDs

• MIM: 605343
• HGNC: 3973
• e!Ensembl: ENSG00000070404

Protein

• UniProt ID: O95633
• Protein name: Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)
• Protein function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than
• PDB: 2KCX , 3B4V , 3SEK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07648	Kazal_2	120 → 167	Kazal-type serine protease inhibitor domain	Domain
  PF07648	Kazal_2	195 → 243	Kazal-type serine protease inhibitor domain	Domain
  PF09289	FOLN	99 → 119	Follistatin/Osteonectin-like EGF domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a wide range of tissues. {ECO:0000269|PubMed:11459787}.
• Sequence:

  MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAE
  CCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCE
  CAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQ
  SCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHA
  GSCAGTPEEPPGGESAEEEENFV

• Sequence length: 263

Pathways

Reactome Pathway

Antagonism of Activin by Follistatin

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Post-translational protein phosphorylation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ENAM 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation. PRSS23 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation. CHGB 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation. AMBN 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation. AMELX 2 shared pathwaysRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation Related via 2 shared pathways including Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ENAM	0	[]	2	["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","Post-translational protein phosphorylation"]	0	[]
PRSS23	0	[]	2	["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","Post-translational protein phosphorylation"]	0	[]
CHGB	0	[]	2	["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","Post-translational protein phosphorylation"]	0	[]
AMBN	0	[]	2	["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","Post-translational protein phosphorylation"]	0	[]
AMELX	0	[]	2	["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)","Post-translational protein phosphorylation"]	0	[]

Diseases Linked via Similar Genes

Amelogenesis imperfecta Linked via 3 of 5 related genesENAM, AMBN, AMELX Dentin dysplasia Linked via 3 of 5 related genesENAM, AMBN, AMELX Dentinogenesis imperfecta Linked via 3 of 5 related genesENAM, AMBN, AMELX Coronary artery disease Linked via 2 of 5 related genesENAM, AMBN Alzheimer disease Linked via 1 of 5 related genesPRSS23

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Amelogenesis imperfecta	3	["ENAM","AMBN","AMELX"]
Dentin dysplasia	3	["ENAM","AMBN","AMELX"]
Dentinogenesis imperfecta	3	["ENAM","AMBN","AMELX"]
Coronary artery disease	2	["ENAM","AMBN"]
Alzheimer disease	1	["PRSS23"]