FMO2 (flavin containing dimethylaniline monoxygenase 2)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2327
• Gene name: Flavin containing dimethylaniline monoxygenase 2
• Gene symbol: FMO2
• Synonyms (NCBI Gene): FMO1B1
• Chromosome: 1
• Chromosome location: 1q24.3
• Summary: This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*

miRNA Show/Hide all (233)

miRTarBase ID	miRNA	Experiments	Reference
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999700	hsa-miR-1343	CLIP-seq
MIRT999701	hsa-miR-140-3p	CLIP-seq
MIRT999702	hsa-miR-1587	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999705	hsa-miR-2682	CLIP-seq
MIRT999706	hsa-miR-3074-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999708	hsa-miR-3126-5p	CLIP-seq
MIRT999709	hsa-miR-3136-3p	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT999712	hsa-miR-328	CLIP-seq
MIRT999713	hsa-miR-34a	CLIP-seq
MIRT999714	hsa-miR-34c-5p	CLIP-seq
MIRT999715	hsa-miR-3545-3p	CLIP-seq
MIRT999716	hsa-miR-3646	CLIP-seq
MIRT999717	hsa-miR-3659	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999719	hsa-miR-4419a	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999722	hsa-miR-4481	CLIP-seq
MIRT999723	hsa-miR-4492	CLIP-seq
MIRT999724	hsa-miR-4498	CLIP-seq
MIRT999725	hsa-miR-449a	CLIP-seq
MIRT999726	hsa-miR-449b	CLIP-seq
MIRT999727	hsa-miR-449c	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999729	hsa-miR-4510	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999731	hsa-miR-4514	CLIP-seq
MIRT999732	hsa-miR-4656	CLIP-seq
MIRT999733	hsa-miR-4658	CLIP-seq
MIRT999734	hsa-miR-4662a-3p	CLIP-seq
MIRT999735	hsa-miR-4675	CLIP-seq
MIRT999736	hsa-miR-4692	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999738	hsa-miR-4741	CLIP-seq
MIRT999739	hsa-miR-4745-5p	CLIP-seq
MIRT999740	hsa-miR-4758-5p	CLIP-seq
MIRT999741	hsa-miR-4777-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999743	hsa-miR-574-5p	CLIP-seq
MIRT999744	hsa-miR-630	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999746	hsa-miR-762	CLIP-seq
MIRT999747	hsa-miR-9	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT1996315	hsa-miR-149	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT1996316	hsa-miR-3064-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT1996317	hsa-miR-3667-3p	CLIP-seq
MIRT1996318	hsa-miR-412	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT1996319	hsa-miR-4448	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT1996321	hsa-miR-4768-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996323	hsa-miR-4794	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT1996326	hsa-miR-494	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT2230239	hsa-miR-1305	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT2230240	hsa-miR-21	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT2230241	hsa-miR-330-3p	CLIP-seq
MIRT2230242	hsa-miR-3614-3p	CLIP-seq
MIRT2230243	hsa-miR-4257	CLIP-seq
MIRT2230244	hsa-miR-4265	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT2230245	hsa-miR-4296	CLIP-seq
MIRT2230246	hsa-miR-4312	CLIP-seq
MIRT2230247	hsa-miR-4322	CLIP-seq
MIRT2230248	hsa-miR-4417	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT2230249	hsa-miR-4640-5p	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT2230250	hsa-miR-4714-3p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT2230251	hsa-miR-4726-5p	CLIP-seq
MIRT2230252	hsa-miR-4756-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT2230253	hsa-miR-590-5p	CLIP-seq
MIRT2230254	hsa-miR-627	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IBA
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IDA	11744609
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IDA	11744609
GO:0006739	Process	NADP+ metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	IBA
GO:0006805	Process	Xenobiotic metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	IEA
GO:0009404	Process	Toxin metabolic process	IDA	11744609
GO:0016020	Component	Membrane	IDA	9804831
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0046322	Process	Negative regulation of fatty acid oxidation	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0050661	Function	NADP binding	IEA
GO:0072592	Process	Oxygen metabolic process	IEA
GO:0097009	Process	Energy homeostasis	IEA

Other IDs

• MIM: 603955
• HGNC: 3770
• e!Ensembl: ENSG00000094963

Protein

• UniProt ID: Q99518
• Protein name: Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)
• Protein function: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:15144220, PubMed:1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00743	FMO-like	2 → 533	Flavin-binding monooxygenase-like	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}.
• Sequence:

  MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVT
  NTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFS
  SSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPD
  GFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFR
  SMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVK
  STVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAH
  LDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLF
  GESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQ
  WEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

• Sequence length: 535

Pathways

KEGG Pathway	Reactome Pathway
Taurine and hypotaurine metabolism	FMO oxidises nucleophiles
Drug metabolism - cytochrome P450
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	35663546	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	36428691	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	20864642	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEROPIA	—	GWAS catalog	33830181	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

FMO1 3 shared pathwaysTaurine and hypotaurine metabolism, Drug metabolism - cytochrome P450, FMO oxidises nucleophiles Related via 3 shared pathways including Taurine and hypotaurine metabolism, Drug metabolism - cytochrome P450. FMO3 3 shared pathwaysTaurine and hypotaurine metabolism, Drug metabolism - cytochrome P450, FMO oxidises nucleophiles Related via 3 shared pathways including Taurine and hypotaurine metabolism, Drug metabolism - cytochrome P450. ARHGAP28 2 shared evidence sourcesCTD (Endometriosis), Disgenet (Endometriosis) Related via 2 shared evidence sources. CNIH3 2 shared evidence sourcesCTD (Endometriosis), Disgenet (Endometriosis) Related via 2 shared evidence sources. DDX5 2 shared evidence sourcesCTD (Endometriosis), Disgenet (Endometriosis) Related via 2 shared evidence sources.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
FMO1	0	[]	3	["Taurine and hypotaurine metabolism","Drug metabolism - cytochrome P450","FMO oxidises nucleophiles"]	0	[]
FMO3	0	[]	3	["Taurine and hypotaurine metabolism","Drug metabolism - cytochrome P450","FMO oxidises nucleophiles"]	0	[]
ARHGAP28	0	[]	0	[]	2	["CTD (Endometriosis)","Disgenet (Endometriosis)"]
CNIH3	0	[]	0	[]	2	["CTD (Endometriosis)","Disgenet (Endometriosis)"]
DDX5	0	[]	0	[]	2	["CTD (Endometriosis)","Disgenet (Endometriosis)"]

Diseases Linked via Similar Genes

Central nervous system cancer Linked via 2 of 5 related genesARHGAP28, CNIH3 Glioblastoma Linked via 2 of 5 related genesARHGAP28, CNIH3 Glioma Linked via 2 of 5 related genesARHGAP28, CNIH3 Schizophrenia Linked via 2 of 5 related genesARHGAP28, CNIH3 Amyotrophic lateral sclerosis Linked via 1 of 5 related genesFMO1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Central nervous system cancer	2	["ARHGAP28","CNIH3"]
Glioblastoma	2	["ARHGAP28","CNIH3"]
Glioma	2	["ARHGAP28","CNIH3"]
Schizophrenia	2	["ARHGAP28","CNIH3"]
Amyotrophic lateral sclerosis	1	["FMO1"]