ELK1 (ETS transcription factor ELK1)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2002
• Gene name: ETS transcription factor ELK1
• Gene symbol: ELK1
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xp11.23
• Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the prom

miRNA Show/Hide all (237)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021088	hsa-miR-186-5p	Sequencing	20371350
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630638	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT665031	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT665030	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT665029	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT665028	hsa-miR-103b	HITS-CLIP	23824327
MIRT665027	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT665026	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT665025	hsa-miR-378g	HITS-CLIP	23824327
MIRT665024	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT665023	hsa-miR-3135b	HITS-CLIP	23824327
MIRT665022	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT665021	hsa-miR-3652	HITS-CLIP	23824327
MIRT665020	hsa-miR-4430	HITS-CLIP	23824327
MIRT665019	hsa-miR-4656	HITS-CLIP	23824327
MIRT665018	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT665017	hsa-miR-4492	HITS-CLIP	23824327
MIRT665016	hsa-miR-4498	HITS-CLIP	23824327
MIRT665015	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT665014	hsa-miR-762	HITS-CLIP	23824327
MIRT665012	hsa-miR-4675	HITS-CLIP	23824327
MIRT665013	hsa-miR-4741	HITS-CLIP	23824327
MIRT665011	hsa-miR-5698	HITS-CLIP	23824327
MIRT665010	hsa-miR-4527	HITS-CLIP	23824327
MIRT665009	hsa-miR-6503-5p	HITS-CLIP	23824327
MIRT665008	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT665007	hsa-miR-7107-3p	HITS-CLIP	23824327
MIRT665006	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT665005	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT665004	hsa-miR-1587	HITS-CLIP	23824327
MIRT665003	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT658737	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT630645	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT658736	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT658735	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658734	hsa-miR-1225-3p	HITS-CLIP	23824327
MIRT658733	hsa-miR-1233-3p	HITS-CLIP	23824327
MIRT658732	hsa-miR-3135a	HITS-CLIP	23824327
MIRT658731	hsa-miR-4294	HITS-CLIP	23824327
MIRT658730	hsa-miR-4792	HITS-CLIP	23824327
MIRT658729	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT630650	hsa-miR-8485	HITS-CLIP	23824327
MIRT630649	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT630648	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT630647	hsa-miR-603	HITS-CLIP	23824327
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630640	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT630650	hsa-miR-8485	HITS-CLIP	23824327
MIRT630649	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT630648	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT630647	hsa-miR-603	HITS-CLIP	23824327
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630645	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT630644	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT630643	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630642	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT630641	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT630640	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630638	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT630636	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630638	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT665031	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT665030	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT665029	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT665028	hsa-miR-103b	HITS-CLIP	23824327
MIRT665027	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT665026	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT665025	hsa-miR-378g	HITS-CLIP	23824327
MIRT665024	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT665023	hsa-miR-3135b	HITS-CLIP	23824327
MIRT665022	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT665021	hsa-miR-3652	HITS-CLIP	23824327
MIRT665020	hsa-miR-4430	HITS-CLIP	23824327
MIRT665019	hsa-miR-4656	HITS-CLIP	23824327
MIRT665018	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT665017	hsa-miR-4492	HITS-CLIP	23824327
MIRT665016	hsa-miR-4498	HITS-CLIP	23824327
MIRT665015	hsa-miR-5001-5p	HITS-CLIP	23824327
MIRT665014	hsa-miR-762	HITS-CLIP	23824327
MIRT665012	hsa-miR-4675	HITS-CLIP	23824327
MIRT665013	hsa-miR-4741	HITS-CLIP	23824327
MIRT665011	hsa-miR-5698	HITS-CLIP	23824327
MIRT665010	hsa-miR-4527	HITS-CLIP	23824327
MIRT665009	hsa-miR-6503-5p	HITS-CLIP	23824327
MIRT665008	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT665007	hsa-miR-7107-3p	HITS-CLIP	23824327
MIRT665006	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT665005	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT665004	hsa-miR-1587	HITS-CLIP	23824327
MIRT665003	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT658737	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT630645	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT658736	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT658735	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT658734	hsa-miR-1225-3p	HITS-CLIP	23824327
MIRT658733	hsa-miR-1233-3p	HITS-CLIP	23824327
MIRT658732	hsa-miR-3135a	HITS-CLIP	23824327
MIRT658731	hsa-miR-4294	HITS-CLIP	23824327
MIRT658730	hsa-miR-4792	HITS-CLIP	23824327
MIRT658729	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT630650	hsa-miR-8485	HITS-CLIP	23824327
MIRT630649	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT630648	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT630647	hsa-miR-603	HITS-CLIP	23824327
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630640	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT630650	hsa-miR-8485	HITS-CLIP	23824327
MIRT630649	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT630648	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT630647	hsa-miR-603	HITS-CLIP	23824327
MIRT630646	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT630645	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT630644	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT630643	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT630642	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT630641	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT630640	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT630639	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630638	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT630637	hsa-miR-3941	HITS-CLIP	23824327
MIRT630636	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT756066	hsa-miR-340-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), RNA pull down assay	34455918
MIRT960244	hsa-miR-1324	CLIP-seq
MIRT960245	hsa-miR-3166	CLIP-seq
MIRT960246	hsa-miR-3190	CLIP-seq
MIRT960247	hsa-miR-382	CLIP-seq
MIRT960248	hsa-miR-3919	CLIP-seq
MIRT960249	hsa-miR-3926	CLIP-seq
MIRT960250	hsa-miR-4292	CLIP-seq
MIRT960251	hsa-miR-4308	CLIP-seq
MIRT960252	hsa-miR-4469	CLIP-seq
MIRT960253	hsa-miR-4691-5p	CLIP-seq
MIRT960254	hsa-miR-4752	CLIP-seq
MIRT960255	hsa-miR-548s	CLIP-seq
MIRT960256	hsa-miR-570	CLIP-seq
MIRT960257	hsa-miR-671-5p	CLIP-seq
MIRT960258	hsa-miR-185	CLIP-seq
MIRT960259	hsa-miR-3150b-3p	CLIP-seq
MIRT960260	hsa-miR-3175	CLIP-seq
MIRT960246	hsa-miR-3190	CLIP-seq
MIRT960247	hsa-miR-382	CLIP-seq
MIRT960248	hsa-miR-3919	CLIP-seq
MIRT960261	hsa-miR-4270	CLIP-seq
MIRT960262	hsa-miR-4306	CLIP-seq
MIRT960263	hsa-miR-4441	CLIP-seq
MIRT960264	hsa-miR-4644	CLIP-seq
MIRT960265	hsa-miR-4652-3p	CLIP-seq
MIRT960266	hsa-miR-4723-5p	CLIP-seq
MIRT960254	hsa-miR-4752	CLIP-seq
MIRT960267	hsa-miR-4781-5p	CLIP-seq
MIRT960268	hsa-miR-4784	CLIP-seq
MIRT960256	hsa-miR-570	CLIP-seq
MIRT960257	hsa-miR-671-5p	CLIP-seq
MIRT960269	hsa-miR-765	CLIP-seq
MIRT960270	hsa-miR-885-3p	CLIP-seq
MIRT1984477	hsa-miR-1278	CLIP-seq
MIRT1984478	hsa-miR-1321	CLIP-seq
MIRT960258	hsa-miR-185	CLIP-seq
MIRT1984479	hsa-miR-193a-3p	CLIP-seq
MIRT1984480	hsa-miR-193b	CLIP-seq
MIRT1984481	hsa-miR-2110	CLIP-seq
MIRT1984482	hsa-miR-3064-5p	CLIP-seq
MIRT1984483	hsa-miR-3150a-3p	CLIP-seq
MIRT960245	hsa-miR-3166	CLIP-seq
MIRT960260	hsa-miR-3175	CLIP-seq
MIRT1984484	hsa-miR-3184	CLIP-seq
MIRT1984485	hsa-miR-361-3p	CLIP-seq
MIRT1984486	hsa-miR-3661	CLIP-seq
MIRT1984487	hsa-miR-3689d	CLIP-seq
MIRT1984488	hsa-miR-3976	CLIP-seq
MIRT1984489	hsa-miR-423-5p	CLIP-seq
MIRT1984490	hsa-miR-4254	CLIP-seq
MIRT960261	hsa-miR-4270	CLIP-seq
MIRT1984491	hsa-miR-4271	CLIP-seq
MIRT960262	hsa-miR-4306	CLIP-seq
MIRT960263	hsa-miR-4441	CLIP-seq
MIRT960252	hsa-miR-4469	CLIP-seq
MIRT1984492	hsa-miR-4505	CLIP-seq
MIRT960264	hsa-miR-4644	CLIP-seq
MIRT960266	hsa-miR-4723-5p	CLIP-seq
MIRT1984493	hsa-miR-4725-3p	CLIP-seq
MIRT1984494	hsa-miR-4739	CLIP-seq
MIRT1984495	hsa-miR-4756-5p	CLIP-seq
MIRT1984496	hsa-miR-619	CLIP-seq
MIRT1984497	hsa-miR-631	CLIP-seq
MIRT1984498	hsa-miR-769-5p	CLIP-seq
MIRT1984499	hsa-miR-892b	CLIP-seq
MIRT1984500	hsa-miR-924	CLIP-seq
MIRT1984501	hsa-miR-939	CLIP-seq
MIRT1984477	hsa-miR-1278	CLIP-seq
MIRT960258	hsa-miR-185	CLIP-seq
MIRT960260	hsa-miR-3175	CLIP-seq
MIRT1984485	hsa-miR-361-3p	CLIP-seq
MIRT1984486	hsa-miR-3661	CLIP-seq
MIRT2219556	hsa-miR-3922-5p	CLIP-seq
MIRT1984490	hsa-miR-4254	CLIP-seq
MIRT960261	hsa-miR-4270	CLIP-seq
MIRT2219557	hsa-miR-4286	CLIP-seq
MIRT960262	hsa-miR-4306	CLIP-seq
MIRT960263	hsa-miR-4441	CLIP-seq
MIRT960264	hsa-miR-4644	CLIP-seq
MIRT2219558	hsa-miR-4661-3p	CLIP-seq
MIRT960266	hsa-miR-4723-5p	CLIP-seq
MIRT2219559	hsa-miR-4726-3p	CLIP-seq
MIRT960267	hsa-miR-4781-5p	CLIP-seq
MIRT1984496	hsa-miR-619	CLIP-seq
MIRT2219560	hsa-miR-627	CLIP-seq
MIRT1984497	hsa-miR-631	CLIP-seq
MIRT1984498	hsa-miR-769-5p	CLIP-seq
MIRT960270	hsa-miR-885-3p	CLIP-seq
MIRT1984500	hsa-miR-924	CLIP-seq
MIRT1984485	hsa-miR-361-3p	CLIP-seq
MIRT960244	hsa-miR-1324	CLIP-seq
MIRT960245	hsa-miR-3166	CLIP-seq
MIRT960246	hsa-miR-3190	CLIP-seq
MIRT960247	hsa-miR-382	CLIP-seq
MIRT960248	hsa-miR-3919	CLIP-seq
MIRT960265	hsa-miR-4652-3p	CLIP-seq
MIRT960254	hsa-miR-4752	CLIP-seq
MIRT960256	hsa-miR-570	CLIP-seq
MIRT960257	hsa-miR-671-5p	CLIP-seq
MIRT960244	hsa-miR-1324	CLIP-seq
MIRT960245	hsa-miR-3166	CLIP-seq
MIRT1984492	hsa-miR-4505	CLIP-seq
MIRT2679913	hsa-miR-4728-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
LMO2	Unknown	22517897
NR3C1	Repression	17016446

Gene ontology (GO) Show/Hide all (55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	31146003
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12750007
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	10799319
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12750007
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	31146003
GO:0001889	Process	Liver development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	14970218
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16291755, 17036045, 17296730, 19684601, 23395904, 25241761, 27852061, 32814053, 32911434
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IC	14970218
GO:0005634	Component	Nucleus	IDA	20018936
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0009416	Process	Response to light stimulus	IEA
GO:0010467	Process	Gene expression	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030324	Process	Lung development	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0036033	Function	Mediator complex binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	15790681
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	17296730
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	31146003
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12750007, 14970218
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	22065586
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	26612202
GO:0071394	Process	Cellular response to testosterone stimulus	IEA
GO:0071396	Process	Cellular response to lipid	IEA
GO:0071480	Process	Cellular response to gamma radiation	IEA
GO:0071774	Process	Response to fibroblast growth factor	IEA
GO:0071774	Process	Response to fibroblast growth factor	ISS
GO:0110088	Process	Hippocampal neuron apoptotic process	IEA
GO:0140416	Function	Transcription regulator inhibitor activity	IEA
GO:0140537	Function	Transcription regulator activator activity	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 311040
• HGNC: 3321
• e!Ensembl: ENSG00000126767

Protein

• UniProt ID: P19419
• Protein name: ETS domain-containing protein Elk-1
• Protein function: Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such
• PDB: 1DUX , 5VVT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00178	Ets	6 → 86	Ets-domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Lung and testis.
• Sequence:

  MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL
  SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH
  AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV
  LPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL
  GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH
  AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH
  TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV
  LSPGPQKP

• Sequence length: 428

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	NGF-stimulated transcription
ErbB signaling pathway	HCMV Early Events
Ras signaling pathway	Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Focal adhesion
Insulin signaling pathway
GnRH signaling pathway
Oxytocin signaling pathway
Leishmaniasis
Hepatitis B
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Pathways in cancer
Proteoglycans in cancer
Endometrial cancer
Hepatocellular carcinoma

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SOS2 11 shared pathwaysMAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Focal adhesion, Insulin signaling pathway, GnRH signaling pathway, Hepatitis B, Human cytomegalovirus infection, Proteoglycans in cancer, Endometrial cancer, Hepatocellular carcinoma Related via 11 shared pathways including MAPK signaling pathway, ErbB signaling pathway. SRF 4 shared pathwaysMAPK signaling pathway, Human T-cell leukemia virus 1 infection, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, NGF-stimulated transcription Related via 4 shared pathways including MAPK signaling pathway, Human T-cell leukemia virus 1 infection. IGF2 4 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Proteoglycans in cancer, Hepatocellular carcinoma Related via 4 shared pathways including MAPK signaling pathway, Ras signaling pathway. RASGRF1 3 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Focal adhesion Related via 3 shared pathways including MAPK signaling pathway, Ras signaling pathway. PPP1R12C 3 shared pathwaysFocal adhesion, Oxytocin signaling pathway, Proteoglycans in cancer Related via 3 shared pathways including Focal adhesion, Oxytocin signaling pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SOS2	0	[]	11	["MAPK signaling pathway","ErbB signaling pathway","Ras signaling pathway","Focal adhesion","Insulin signaling pathway","GnRH signaling pathway","Hepatitis B","Human cytomegalovirus infection","Proteoglycans in cancer","Endometrial cancer","Hepatocellular carcinoma"]	0	[]
SRF	0	[]	4	["MAPK signaling pathway","Human T-cell leukemia virus 1 infection","Estrogen-dependent nuclear events downstream of ESR-membrane signaling","NGF-stimulated transcription"]	0	[]
IGF2	0	[]	4	["MAPK signaling pathway","Ras signaling pathway","Proteoglycans in cancer","Hepatocellular carcinoma"]	0	[]
RASGRF1	0	[]	3	["MAPK signaling pathway","Ras signaling pathway","Focal adhesion"]	0	[]
PPP1R12C	0	[]	3	["Focal adhesion","Oxytocin signaling pathway","Proteoglycans in cancer"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 3 of 5 related genesSOS2, IGF2, RASGRF1 Desbuquois syndrome Linked via 2 of 5 related genesSOS2, IGF2 Gout Linked via 2 of 5 related genesSOS2, IGF2 Cardiovascular disease Linked via 1 of 5 related genesSOS2 Kidney disease Linked via 1 of 5 related genesSOS2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	3	["SOS2","IGF2","RASGRF1"]
Desbuquois syndrome	2	["SOS2","IGF2"]
Gout	2	["SOS2","IGF2"]
Cardiovascular disease	1	["SOS2"]
Kidney disease	1	["SOS2"]