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Gene Gene information from NCBI Gene database.
Entrez ID 30846
Gene name EH domain containing 2
Gene symbol EHD2
Synonyms (NCBI Gene)
PAST2
Chromosome 19
Chromosome location 19q13.33
Summary This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein
miRNA miRNA information provided by mirtarbase database.
701 Show/Hide all (701)
miRTarBase ID miRNA Experiments Reference
MIRT004199 hsa-miR-197-3p Microarray 16822819
MIRT022318 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT054209 hsa-miR-210-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 23028679
MIRT608445 hsa-miR-8485 HITS-CLIP 19536157
MIRT608444 hsa-miR-329-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
50 Show/Hide all (50)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003676 Function Nucleic acid binding TAS 10673336
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 17233914, 25588833
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605890 3243 ENSG00000024422
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZN4
Protein name EH domain-containing protein 2 (PAST homolog 2)
Protein function ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internali
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00350 Dynamin_N 61 → 221 Dynamin family Domain
PF12763 EF-hand_4 443 → 539 Cytoskeletal-regulatory complex EF hand Family
PF16880 EHD_N 24 → 56 N-terminal EH-domain containing protein Family
PF18150 DUF5600 288 → 394 Domain of unknown function (DUF5600) Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. {ECO:0000269|PubMed:10673336}.
Sequence
Sequence length 543
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocytosis Factors involved in megakaryocyte development and platelet production