Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1949
Gene name	Ephrin B3
Gene symbol	EFNB3
Synonyms (NCBI Gene)	EFL6EPLG8LERK8
Chromosome	17
Chromosome location	17p13.1
Summary	EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT042247	hsa-miR-484	CLASH	23622248
MIRT954263	hsa-miR-1248	CLIP-seq
MIRT954264	hsa-miR-1249	CLIP-seq
MIRT954265	hsa-miR-1262	CLIP-seq
MIRT954266	hsa-miR-1293	CLIP-seq
MIRT954267	hsa-miR-145	CLIP-seq
MIRT954268	hsa-miR-3074-5p	CLIP-seq
MIRT954269	hsa-miR-3184	CLIP-seq
MIRT954270	hsa-miR-326	CLIP-seq
MIRT954271	hsa-miR-330-5p	CLIP-seq
MIRT954272	hsa-miR-370	CLIP-seq
MIRT954273	hsa-miR-423-5p	CLIP-seq
MIRT954274	hsa-miR-4258	CLIP-seq
MIRT954275	hsa-miR-4483	CLIP-seq
MIRT954276	hsa-miR-4659a-3p	CLIP-seq
MIRT954277	hsa-miR-4659b-3p	CLIP-seq
MIRT954278	hsa-miR-4701-3p	CLIP-seq
MIRT954279	hsa-miR-4710	CLIP-seq
MIRT954280	hsa-miR-4716-3p	CLIP-seq
MIRT954281	hsa-miR-4778-3p	CLIP-seq
MIRT954282	hsa-miR-4793-3p	CLIP-seq
MIRT954283	hsa-miR-515-5p	CLIP-seq
MIRT954284	hsa-miR-942	CLIP-seq
MIRT1982592	hsa-miR-1231	CLIP-seq
MIRT1982593	hsa-miR-3652	CLIP-seq
MIRT1982594	hsa-miR-3655	CLIP-seq
MIRT1982595	hsa-miR-4288	CLIP-seq
MIRT1982596	hsa-miR-4430	CLIP-seq
MIRT1982597	hsa-miR-4766-5p	CLIP-seq
MIRT1982598	hsa-miR-632	CLIP-seq
MIRT2217510	hsa-miR-122	CLIP-seq
MIRT2217511	hsa-miR-138	CLIP-seq
MIRT2217512	hsa-miR-1914	CLIP-seq
MIRT2217513	hsa-miR-3065-3p	CLIP-seq
MIRT2217514	hsa-miR-3160-3p	CLIP-seq
MIRT1982593	hsa-miR-3652	CLIP-seq
MIRT2217515	hsa-miR-4299	CLIP-seq
MIRT1982596	hsa-miR-4430	CLIP-seq
MIRT2217516	hsa-miR-4457	CLIP-seq
MIRT2217517	hsa-miR-4487	CLIP-seq
MIRT2217518	hsa-miR-4505	CLIP-seq
MIRT2217519	hsa-miR-4668-3p	CLIP-seq
MIRT2217520	hsa-miR-4749-3p	CLIP-seq
MIRT2217521	hsa-miR-558	CLIP-seq
MIRT2217522	hsa-miR-647	CLIP-seq
MIRT2387243	hsa-miR-3926	CLIP-seq
MIRT2387244	hsa-miR-548s	CLIP-seq

Transcription factor	Regulation	Reference
MYCN	Activation	19885598

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0005005	Function	Transmembrane-ephrin receptor activity	TAS	9126477
GO:0005515	Function	Protein binding	IPI	23812375, 28514442, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17251577
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9126477
GO:0007267	Process	Cell-cell signaling	IEA
GO:0007267	Process	Cell-cell signaling	TAS	9126477
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	9126477
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007628	Process	Adult walking behavior	IEA
GO:0016020	Component	Membrane	IEA
GO:0016198	Process	Axon choice point recognition	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031295	Process	T cell costimulation	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0046875	Function	Ephrin receptor binding	IBA
GO:0046875	Function	Ephrin receptor binding	IDA	8808709
GO:0046875	Function	Ephrin receptor binding	IPI	11519828
GO:0048013	Process	Ephrin receptor signaling pathway	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	IDA	8808709
GO:0050771	Process	Negative regulation of axonogenesis	IEA
GO:0050771	Process	Negative regulation of axonogenesis	ISS
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099557	Process	Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IEA

MIM	HGNC	e!Ensembl
602297	3228	ENSG00000108947

Q15768

Protein name

Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)

Protein function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing o

PDB

4BKF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00812	Ephrin	28 → 167	Ephrin	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Sequence

MGPPHSGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDL
LCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEY
SPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKP
VSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEGPLPPPSMPAVAGAAGGLALLLL
GVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPREAEPGELGIALRGG
GAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV

Sequence length

340

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Axon guidance	EPH-Ephrin signaling
	EPHB-mediated forward signaling
	Ephrin signaling
	EPH-ephrin mediated repulsion of cells

EFNB3 (ephrin B3)

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