DEFB4A (defensin beta 4A) | GeDiPNet

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Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1673
Gene name	Defensin beta 4A
Gene symbol	DEFB4A
Synonyms (NCBI Gene)	BD-2DEFB-2DEFB102DEFB2DEFB4HBD-2SAP1
Chromosome	8
Chromosome location	8p23.1
Summary	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation

2

miRTarBase ID	miRNA	Experiments	Reference
MIRT018520	hsa-miR-335-5p	Microarray	18185580
MIRT029865	hsa-miR-26b-5p	Microarray	19088304

3

Transcription factor	Regulation	Reference
NFKB1	Unknown	11207625;12682256
NFKBIZ	Unknown	18362142
RELA	Unknown	11207625

33 Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20068036, 28514442, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	30050988
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	9727055, 21115716
GO:0005615	Component	Extracellular space	IEA
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0006935	Process	Chemotaxis	IDA	20068036
GO:0006935	Process	Chemotaxis	TAS	10521347
GO:0006952	Process	Defense response	IEA
GO:0006955	Process	Immune response	TAS	10521347
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10521347
GO:0031640	Process	Killing of cells of another organism	IDA	15625724, 19109182
GO:0031640	Process	Killing of cells of another organism	IMP	9727055
GO:0031731	Function	CCR6 chemokine receptor binding	IBA
GO:0031731	Function	CCR6 chemokine receptor binding	IDA	20068036
GO:0042056	Function	Chemoattractant activity	IBA
GO:0042742	Process	Defense response to bacterium	IBA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042742	Process	Defense response to bacterium	IMP	21115716
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	15625724, 20068036
GO:0050829	Process	Defense response to Gram-negative bacterium	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	15625724, 20068036
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA
GO:0050832	Process	Defense response to fungus	IDA	30050988
GO:0050918	Process	Positive chemotaxis	IEA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0061760	Process	Antifungal innate immune response	IDA	30050988
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	19109182, 30050988
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	9727055
GO:0140546	Process	Defense response to symbiont	IEA

MIM	HGNC	e!Ensembl
602215	2767	ENSG00000171711

Interactions View interactions

KEGG Pathway	Reactome Pathway
NOD-like receptor signaling pathway	Beta defensins
IL-17 signaling pathway	Defensins
Staphylococcus aureus infection