DCAF13 (DDB1 and CUL4 associated factor 13)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25879
• Gene name: DDB1 and CUL4 associated factor 13
• Gene symbol: DCAF13
• Synonyms (NCBI Gene): GM83, HSPC064, Sof1, WDSOF1
• Chromosome: 8
• Chromosome location: 8q22.3

miRNA Show/Hide all (107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031737	hsa-miR-16-5p	Proteomics	18668040
MIRT045689	hsa-miR-149-5p	CLASH	23622248
MIRT924637	hsa-miR-2114	CLIP-seq
MIRT924638	hsa-miR-3674	CLIP-seq
MIRT924639	hsa-miR-371-5p	CLIP-seq
MIRT924640	hsa-miR-371b-5p	CLIP-seq
MIRT924641	hsa-miR-450b-5p	CLIP-seq
MIRT924642	hsa-miR-4732-5p	CLIP-seq
MIRT924643	hsa-miR-4762-5p	CLIP-seq
MIRT924644	hsa-miR-4789-5p	CLIP-seq
MIRT924645	hsa-miR-495	CLIP-seq
MIRT924646	hsa-miR-499-3p	CLIP-seq
MIRT924647	hsa-miR-499a-3p	CLIP-seq
MIRT924648	hsa-miR-513c	CLIP-seq
MIRT924649	hsa-miR-514b-5p	CLIP-seq
MIRT924650	hsa-miR-548a-5p	CLIP-seq
MIRT924651	hsa-miR-548ab	CLIP-seq
MIRT924652	hsa-miR-548ak	CLIP-seq
MIRT924653	hsa-miR-548b-5p	CLIP-seq
MIRT924654	hsa-miR-548c-5p	CLIP-seq
MIRT924655	hsa-miR-548d-5p	CLIP-seq
MIRT924656	hsa-miR-548h	CLIP-seq
MIRT924657	hsa-miR-548i	CLIP-seq
MIRT924658	hsa-miR-548j	CLIP-seq
MIRT924659	hsa-miR-548n	CLIP-seq
MIRT924660	hsa-miR-548w	CLIP-seq
MIRT924661	hsa-miR-548y	CLIP-seq
MIRT924662	hsa-miR-554	CLIP-seq
MIRT924663	hsa-miR-559	CLIP-seq
MIRT924664	hsa-miR-802	CLIP-seq
MIRT924665	hsa-miR-944	CLIP-seq
MIRT1973936	hsa-miR-132	CLIP-seq
MIRT924637	hsa-miR-2114	CLIP-seq
MIRT1973937	hsa-miR-212	CLIP-seq
MIRT924638	hsa-miR-3674	CLIP-seq
MIRT1973938	hsa-miR-4477b	CLIP-seq
MIRT1973939	hsa-miR-4717-5p	CLIP-seq
MIRT924642	hsa-miR-4732-5p	CLIP-seq
MIRT924659	hsa-miR-548n	CLIP-seq
MIRT924662	hsa-miR-554	CLIP-seq
MIRT924664	hsa-miR-802	CLIP-seq
MIRT2209513	hsa-miR-3127-5p	CLIP-seq
MIRT2209514	hsa-miR-320a	CLIP-seq
MIRT2209515	hsa-miR-320b	CLIP-seq
MIRT2209516	hsa-miR-320c	CLIP-seq
MIRT2209517	hsa-miR-320d	CLIP-seq
MIRT2209518	hsa-miR-410	CLIP-seq
MIRT2209519	hsa-miR-4429	CLIP-seq
MIRT1973938	hsa-miR-4477b	CLIP-seq
MIRT2209520	hsa-miR-4643	CLIP-seq
MIRT2209521	hsa-miR-466	CLIP-seq
MIRT1973939	hsa-miR-4717-5p	CLIP-seq
MIRT2209522	hsa-miR-4789-3p	CLIP-seq
MIRT2513198	hsa-miR-299-3p	CLIP-seq
MIRT2209513	hsa-miR-3127-5p	CLIP-seq
MIRT2513199	hsa-miR-3190	CLIP-seq
MIRT2513200	hsa-miR-3913-3p	CLIP-seq
MIRT2513201	hsa-miR-4272	CLIP-seq
MIRT2513202	hsa-miR-4317	CLIP-seq
MIRT2513203	hsa-miR-4491	CLIP-seq
MIRT2513204	hsa-miR-4528	CLIP-seq
MIRT2513205	hsa-miR-4657	CLIP-seq
MIRT2513206	hsa-miR-4799-5p	CLIP-seq
MIRT2513207	hsa-miR-4803	CLIP-seq
MIRT2513208	hsa-miR-489	CLIP-seq
MIRT2513209	hsa-miR-494	CLIP-seq
MIRT2513210	hsa-miR-513a-5p	CLIP-seq
MIRT924650	hsa-miR-548a-5p	CLIP-seq
MIRT924651	hsa-miR-548ab	CLIP-seq
MIRT924652	hsa-miR-548ak	CLIP-seq
MIRT924653	hsa-miR-548b-5p	CLIP-seq
MIRT924654	hsa-miR-548c-5p	CLIP-seq
MIRT924655	hsa-miR-548d-5p	CLIP-seq
MIRT924656	hsa-miR-548h	CLIP-seq
MIRT924657	hsa-miR-548i	CLIP-seq
MIRT924658	hsa-miR-548j	CLIP-seq
MIRT924660	hsa-miR-548w	CLIP-seq
MIRT924661	hsa-miR-548y	CLIP-seq
MIRT924663	hsa-miR-559	CLIP-seq
MIRT2513198	hsa-miR-299-3p	CLIP-seq
MIRT2209513	hsa-miR-3127-5p	CLIP-seq
MIRT2513199	hsa-miR-3190	CLIP-seq
MIRT2513200	hsa-miR-3913-3p	CLIP-seq
MIRT2679040	hsa-miR-3973	CLIP-seq
MIRT2513201	hsa-miR-4272	CLIP-seq
MIRT2513202	hsa-miR-4317	CLIP-seq
MIRT2513203	hsa-miR-4491	CLIP-seq
MIRT2513204	hsa-miR-4528	CLIP-seq
MIRT2513205	hsa-miR-4657	CLIP-seq
MIRT2513206	hsa-miR-4799-5p	CLIP-seq
MIRT2513208	hsa-miR-489	CLIP-seq
MIRT2513209	hsa-miR-494	CLIP-seq
MIRT2513210	hsa-miR-513a-5p	CLIP-seq
MIRT2679041	hsa-miR-520g	CLIP-seq
MIRT2679042	hsa-miR-520h	CLIP-seq
MIRT924650	hsa-miR-548a-5p	CLIP-seq
MIRT924651	hsa-miR-548ab	CLIP-seq
MIRT924652	hsa-miR-548ak	CLIP-seq
MIRT924653	hsa-miR-548b-5p	CLIP-seq
MIRT924654	hsa-miR-548c-5p	CLIP-seq
MIRT924655	hsa-miR-548d-5p	CLIP-seq
MIRT924656	hsa-miR-548h	CLIP-seq
MIRT924657	hsa-miR-548i	CLIP-seq
MIRT924658	hsa-miR-548j	CLIP-seq
MIRT924660	hsa-miR-548w	CLIP-seq
MIRT924661	hsa-miR-548y	CLIP-seq
MIRT924663	hsa-miR-559	CLIP-seq

Gene ontology (GO) Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0001555	Process	Oocyte growth	IEA
GO:0001555	Process	Oocyte growth	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	28068668, 30111536
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	30111536
GO:0005730	Component	Nucleolus	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	ISS
GO:0007056	Process	Spindle assembly involved in female meiosis	IDA	31492966
GO:0007056	Process	Spindle assembly involved in female meiosis	IDA	31492966
GO:0007292	Process	Female gamete generation	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	28068668
GO:0032040	Component	Small-subunit processome	IBA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	30111536, 31492966
GO:0044725	Process	Epigenetic programming in the zygotic pronuclei	IDA	30111536
GO:0044725	Process	Epigenetic programming in the zygotic pronuclei	IDA	30111536
GO:0046697	Process	Decidualization	IDA	35932979
GO:0046697	Process	Decidualization	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	31492966
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	16949367, 30111536, 31492966
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	30111536, 31492966
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 616196
• HGNC: 24535
• e!Ensembl: ENSG00000164934

Protein

• UniProt ID: Q9NV06
• Protein name: DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1)
• Protein function: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associat
• PDB: 7MQ8 , 7MQ9 , 7MQA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	57 → 95	WD domain, G-beta repeat	Repeat
  PF00400	WD40	99 → 137	WD domain, G-beta repeat	Repeat
  PF00400	WD40	317 → 353	WD domain, G-beta repeat	Repeat
  PF04158	Sof1	354 → 440	Sof1-like domain	Family
  PF08662	eIF2A	173 → 311	Eukaryotic translation initiation factor eIF2A	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the endometrium during decidualization. Expression is down-regulated in preeclampsia decidual tissues. {ECO:0000269|PubMed:35932979}.
• Sequence:

  MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLA
  SLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFC
  GTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDI
  WDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMR
  TNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSA
  SFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKL
  GVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVN
  RIKHSKPGSVPLVSEKKKHVVAVVK

• Sequence length: 445

Pathways

Reactome Pathway

Major pathway of rRNA processing in the nucleolus and cytosol

Neddylation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

UBA52 2 shared pathwaysNeddylation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Neddylation, Major pathway of rRNA processing in the nucleolus and cytosol. RPS27A 2 shared pathwaysNeddylation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Neddylation, Major pathway of rRNA processing in the nucleolus and cytosol.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
UBA52	0	[]	2	["Neddylation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
RPS27A	0	[]	2	["Neddylation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]

Diseases Linked via Similar Genes

Osteoarthritis Linked via 1 of 2 related genesUBA52

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Osteoarthritis	1	["UBA52"]