Gene Gene information from NCBI Gene database.
Entrez ID 6233
Gene name Ribosomal protein S27a
Gene symbol RPS27A
Synonyms (NCBI Gene)
CEP80HEL112S27AUBA80UBCUBCEP1UBCEP80eS31
Chromosome 2
Chromosome location 2p16.1
Summary Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated p
miRNA miRNA information provided by mirtarbase database.
850
miRTarBase ID miRNA Experiments Reference
MIRT050798 hsa-miR-17-5p CLASH 23622248
MIRT050094 hsa-miR-26a-5p CLASH 23622248
MIRT047980 hsa-miR-30c-5p CLASH 23622248
MIRT046242 hsa-miR-23b-3p CLASH 23622248
MIRT046153 hsa-miR-30b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003735 Function Structural constituent of ribosome HDA 15883184
GO:0003735 Function Structural constituent of ribosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
191343 10417 ENSG00000143947
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62979
Protein name Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Protein function [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys re
PDB 2KHW , 2KOX , 2KTF , 2KWU , 2KWV , 2L0F , 2L0T , 2XK5 , 3AXC , 3I3T , 3K9P , 3N30 , 3N32 , 3NHE , 3NOB , 3NS8 , 3PHD , 3PHW , 3TBL , 3VDZ , 4R62 , 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5T2C , 5WVO , 5YDK , 6DC6 , 6FEC , 6G18 , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6J99 , 6KFP , 6KG6 , 6KIU , 6KIV , 6KIW , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin 3 74 Ubiquitin family Domain
PF01599 Ribosomal_S27 102 147 Ribosomal protein S27a Domain
Sequence
Sequence length 156
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Familial cancer of breast Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 24680683
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 34326892, 36195955, 36405716 Associate
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 28282387
★☆☆☆☆
Found in Text Mining only
Anemia, Diamond-Blackfan Anemia GENOMICS_ENGLAND_DG 26942564
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial Fibrillation BEFREE 31700166
★☆☆☆☆
Found in Text Mining only
Bladder neck obstruction Bladder neck obstruction BEFREE 21356374
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 22606272
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 32444848 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 8541345
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 22258406, 36378050 Associate
★☆☆☆☆
Found in Text Mining only