CRNKL1 (crooked neck pre-mRNA splicing factor 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51340
• Gene name: Crooked neck pre-mRNA splicing factor 1
• Gene symbol: CRNKL1
• Synonyms (NCBI Gene): CLF, CRN, Clf1, HCRN, MSTP021, SYF3
• Chromosome: 20
• Chromosome location: 20p11.23
• Summary: The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the

miRNA Show/Hide all (324)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045227	hsa-miR-186-5p	CLASH	23622248
MIRT704464	hsa-miR-8063	HITS-CLIP	23313552
MIRT704463	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704462	hsa-miR-1284	HITS-CLIP	23313552
MIRT704461	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT704460	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704459	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704458	hsa-miR-3926	HITS-CLIP	23313552
MIRT704457	hsa-miR-3672	HITS-CLIP	23313552
MIRT704456	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT704455	hsa-miR-548s	HITS-CLIP	23313552
MIRT548707	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT548706	hsa-miR-548ab	PAR-CLIP	21572407
MIRT548705	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT548704	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT548703	hsa-miR-548ak	PAR-CLIP	21572407
MIRT548702	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT548701	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT548700	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT548699	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT548698	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT548697	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT548696	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT548695	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT548694	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT548693	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT548692	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT548691	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT548690	hsa-miR-548i	PAR-CLIP	21572407
MIRT548689	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT548688	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT548687	hsa-miR-548w	PAR-CLIP	21572407
MIRT548686	hsa-miR-548y	PAR-CLIP	21572407
MIRT548685	hsa-miR-559	PAR-CLIP	21572407
MIRT548684	hsa-miR-548ag	PAR-CLIP	21572407
MIRT548683	hsa-miR-548ai	PAR-CLIP	21572407
MIRT548682	hsa-miR-548ba	PAR-CLIP	21572407
MIRT548681	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT548680	hsa-miR-944	PAR-CLIP	21572407
MIRT548678	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT548679	hsa-miR-3923	PAR-CLIP	21572407
MIRT548677	hsa-miR-126-5p	PAR-CLIP	21572407
MIRT548676	hsa-miR-6777-3p	PAR-CLIP	21572407
MIRT548675	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT548674	hsa-miR-3117-5p	PAR-CLIP	21572407
MIRT548673	hsa-miR-4477a	PAR-CLIP	21572407
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22291592
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22291592
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22291592
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22291592
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22291592
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22291592
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22291592
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22291592
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22291592
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22291592
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22291592
MIRT445504	hsa-miR-6086	PAR-CLIP	22291592
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT445504	hsa-miR-6086	PAR-CLIP	22100165
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT445504	hsa-miR-6086	PAR-CLIP	22100165
MIRT704464	hsa-miR-8063	HITS-CLIP	23313552
MIRT704463	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704462	hsa-miR-1284	HITS-CLIP	23313552
MIRT704461	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT704460	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT704459	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT704458	hsa-miR-3926	HITS-CLIP	23313552
MIRT704457	hsa-miR-3672	HITS-CLIP	23313552
MIRT704456	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT704455	hsa-miR-548s	HITS-CLIP	23313552
MIRT548707	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT548706	hsa-miR-548ab	PAR-CLIP	21572407
MIRT548705	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT548704	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT548703	hsa-miR-548ak	PAR-CLIP	21572407
MIRT548702	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT548701	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT548700	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT548699	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT548698	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT548697	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT548696	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT548695	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT548694	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT548693	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT548692	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT548691	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT548690	hsa-miR-548i	PAR-CLIP	21572407
MIRT548689	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT548688	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT548687	hsa-miR-548w	PAR-CLIP	21572407
MIRT548686	hsa-miR-548y	PAR-CLIP	21572407
MIRT548685	hsa-miR-559	PAR-CLIP	21572407
MIRT548684	hsa-miR-548ag	PAR-CLIP	21572407
MIRT548683	hsa-miR-548ai	PAR-CLIP	21572407
MIRT548682	hsa-miR-548ba	PAR-CLIP	21572407
MIRT548681	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT548680	hsa-miR-944	PAR-CLIP	21572407
MIRT548678	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT548679	hsa-miR-3923	PAR-CLIP	21572407
MIRT548677	hsa-miR-126-5p	PAR-CLIP	21572407
MIRT548676	hsa-miR-6777-3p	PAR-CLIP	21572407
MIRT548675	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT548674	hsa-miR-3117-5p	PAR-CLIP	21572407
MIRT548673	hsa-miR-4477a	PAR-CLIP	21572407
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22291592
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22291592
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22291592
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22291592
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22291592
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22291592
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22291592
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22291592
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22291592
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22291592
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22291592
MIRT445504	hsa-miR-6086	PAR-CLIP	22291592
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT445504	hsa-miR-6086	PAR-CLIP	22100165
MIRT445516	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT445515	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT445514	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT445513	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT445512	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT445511	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT445510	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT445509	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445508	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT445507	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT445506	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT445505	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT445504	hsa-miR-6086	PAR-CLIP	22100165
MIRT910403	hsa-miR-1283	CLIP-seq
MIRT910404	hsa-miR-3153	CLIP-seq
MIRT910405	hsa-miR-34b	CLIP-seq
MIRT910406	hsa-miR-3646	CLIP-seq
MIRT910407	hsa-miR-3647-3p	CLIP-seq
MIRT910408	hsa-miR-3662	CLIP-seq
MIRT910409	hsa-miR-3663-3p	CLIP-seq
MIRT910410	hsa-miR-3691-3p	CLIP-seq
MIRT910411	hsa-miR-3915	CLIP-seq
MIRT910412	hsa-miR-3928	CLIP-seq
MIRT910413	hsa-miR-410	CLIP-seq
MIRT910414	hsa-miR-4273	CLIP-seq
MIRT910415	hsa-miR-4481	CLIP-seq
MIRT910416	hsa-miR-4487	CLIP-seq
MIRT910417	hsa-miR-4539	CLIP-seq
MIRT910418	hsa-miR-4646-5p	CLIP-seq
MIRT910419	hsa-miR-4668-5p	CLIP-seq
MIRT910420	hsa-miR-4677-5p	CLIP-seq
MIRT910421	hsa-miR-4680-5p	CLIP-seq
MIRT910422	hsa-miR-4699-3p	CLIP-seq
MIRT910423	hsa-miR-4745-5p	CLIP-seq
MIRT910424	hsa-miR-4758-5p	CLIP-seq
MIRT910425	hsa-miR-4799-5p	CLIP-seq
MIRT910426	hsa-miR-501-3p	CLIP-seq
MIRT910427	hsa-miR-502-3p	CLIP-seq
MIRT910428	hsa-miR-624	CLIP-seq
MIRT1969890	hsa-miR-1825	CLIP-seq
MIRT1969891	hsa-miR-199a-5p	CLIP-seq
MIRT1969892	hsa-miR-199b-5p	CLIP-seq
MIRT1969893	hsa-miR-224	CLIP-seq
MIRT1969894	hsa-miR-3155	CLIP-seq
MIRT1969895	hsa-miR-3155b	CLIP-seq
MIRT1969896	hsa-miR-33a	CLIP-seq
MIRT1969897	hsa-miR-33b	CLIP-seq
MIRT1969898	hsa-miR-3614-5p	CLIP-seq
MIRT1969899	hsa-miR-3913-3p	CLIP-seq
MIRT1969900	hsa-miR-3929	CLIP-seq
MIRT910413	hsa-miR-410	CLIP-seq
MIRT1969901	hsa-miR-4256	CLIP-seq
MIRT910414	hsa-miR-4273	CLIP-seq
MIRT1969902	hsa-miR-4274	CLIP-seq
MIRT1969903	hsa-miR-4299	CLIP-seq
MIRT1969904	hsa-miR-4419b	CLIP-seq
MIRT1969905	hsa-miR-4422	CLIP-seq
MIRT1969906	hsa-miR-4478	CLIP-seq
MIRT910416	hsa-miR-4487	CLIP-seq
MIRT1969907	hsa-miR-4679	CLIP-seq
MIRT1969908	hsa-miR-4803	CLIP-seq
MIRT1969909	hsa-miR-484	CLIP-seq
MIRT1969910	hsa-miR-550b	CLIP-seq
MIRT1969911	hsa-miR-570	CLIP-seq
MIRT2205899	hsa-miR-1262	CLIP-seq
MIRT1969890	hsa-miR-1825	CLIP-seq
MIRT1969891	hsa-miR-199a-5p	CLIP-seq
MIRT1969892	hsa-miR-199b-5p	CLIP-seq
MIRT2205900	hsa-miR-3138	CLIP-seq
MIRT1969894	hsa-miR-3155	CLIP-seq
MIRT1969895	hsa-miR-3155b	CLIP-seq
MIRT2205901	hsa-miR-3168	CLIP-seq
MIRT2205902	hsa-miR-3189-3p	CLIP-seq
MIRT2205903	hsa-miR-34a	CLIP-seq
MIRT2205904	hsa-miR-34c-5p	CLIP-seq
MIRT2205905	hsa-miR-3685	CLIP-seq
MIRT2205906	hsa-miR-384	CLIP-seq
MIRT1969900	hsa-miR-3929	CLIP-seq
MIRT1969902	hsa-miR-4274	CLIP-seq
MIRT2205907	hsa-miR-4277	CLIP-seq
MIRT1969904	hsa-miR-4419b	CLIP-seq
MIRT1969905	hsa-miR-4422	CLIP-seq
MIRT2205908	hsa-miR-4426	CLIP-seq
MIRT2205909	hsa-miR-4434	CLIP-seq
MIRT1969906	hsa-miR-4478	CLIP-seq
MIRT2205910	hsa-miR-4491	CLIP-seq
MIRT2205911	hsa-miR-449a	CLIP-seq
MIRT2205912	hsa-miR-449b	CLIP-seq
MIRT2205913	hsa-miR-4516	CLIP-seq
MIRT2205914	hsa-miR-4520a-3p	CLIP-seq
MIRT2205915	hsa-miR-4531	CLIP-seq
MIRT2205916	hsa-miR-4540	CLIP-seq
MIRT2205917	hsa-miR-4647	CLIP-seq
MIRT2205918	hsa-miR-4657	CLIP-seq
MIRT2205919	hsa-miR-4662b	CLIP-seq
MIRT2205920	hsa-miR-4701-3p	CLIP-seq
MIRT2205921	hsa-miR-4800-5p	CLIP-seq
MIRT1969909	hsa-miR-484	CLIP-seq
MIRT2205922	hsa-miR-516b	CLIP-seq
MIRT2205923	hsa-miR-554	CLIP-seq
MIRT1969911	hsa-miR-570	CLIP-seq
MIRT2205924	hsa-miR-576-3p	CLIP-seq
MIRT2205925	hsa-miR-635	CLIP-seq
MIRT2509141	hsa-miR-1208	CLIP-seq
MIRT2509142	hsa-miR-1243	CLIP-seq
MIRT2509143	hsa-miR-1269	CLIP-seq
MIRT2509144	hsa-miR-1269b	CLIP-seq
MIRT2509145	hsa-miR-1270	CLIP-seq
MIRT2509146	hsa-miR-1273d	CLIP-seq
MIRT2509147	hsa-miR-1305	CLIP-seq
MIRT2509148	hsa-miR-132	CLIP-seq
MIRT2509149	hsa-miR-136	CLIP-seq
MIRT2509150	hsa-miR-141	CLIP-seq
MIRT1969890	hsa-miR-1825	CLIP-seq
MIRT2509151	hsa-miR-183	CLIP-seq
MIRT2509152	hsa-miR-1910	CLIP-seq
MIRT1969891	hsa-miR-199a-5p	CLIP-seq
MIRT1969892	hsa-miR-199b-5p	CLIP-seq
MIRT2509153	hsa-miR-200a	CLIP-seq
MIRT2509154	hsa-miR-212	CLIP-seq
MIRT2509155	hsa-miR-3065-5p	CLIP-seq
MIRT2509156	hsa-miR-3122	CLIP-seq
MIRT2509157	hsa-miR-3148	CLIP-seq
MIRT910404	hsa-miR-3153	CLIP-seq
MIRT1969894	hsa-miR-3155	CLIP-seq
MIRT1969895	hsa-miR-3155b	CLIP-seq
MIRT2509158	hsa-miR-3162-3p	CLIP-seq
MIRT2509159	hsa-miR-3182	CLIP-seq
MIRT2509160	hsa-miR-335	CLIP-seq
MIRT2509161	hsa-miR-338-3p	CLIP-seq
MIRT2509162	hsa-miR-3654	CLIP-seq
MIRT2509163	hsa-miR-371-5p	CLIP-seq
MIRT2509164	hsa-miR-3909	CLIP-seq
MIRT2509165	hsa-miR-3913-5p	CLIP-seq
MIRT1969900	hsa-miR-3929	CLIP-seq
MIRT2509166	hsa-miR-3978	CLIP-seq
MIRT1969902	hsa-miR-4274	CLIP-seq
MIRT1969904	hsa-miR-4419b	CLIP-seq
MIRT1969905	hsa-miR-4422	CLIP-seq
MIRT1969906	hsa-miR-4478	CLIP-seq
MIRT2509167	hsa-miR-4517	CLIP-seq
MIRT2509168	hsa-miR-4520b-3p	CLIP-seq
MIRT2509169	hsa-miR-4529-3p	CLIP-seq
MIRT2509170	hsa-miR-4530	CLIP-seq
MIRT2509171	hsa-miR-4659a-3p	CLIP-seq
MIRT2509172	hsa-miR-4659b-3p	CLIP-seq
MIRT910419	hsa-miR-4668-5p	CLIP-seq
MIRT2509173	hsa-miR-4683	CLIP-seq
MIRT2509174	hsa-miR-4709-5p	CLIP-seq
MIRT1969909	hsa-miR-484	CLIP-seq
MIRT2509175	hsa-miR-498	CLIP-seq
MIRT2509176	hsa-miR-561	CLIP-seq
MIRT1969911	hsa-miR-570	CLIP-seq
MIRT2509177	hsa-miR-577	CLIP-seq
MIRT2509178	hsa-miR-620	CLIP-seq
MIRT2509143	hsa-miR-1269	CLIP-seq
MIRT2509144	hsa-miR-1269b	CLIP-seq
MIRT1969890	hsa-miR-1825	CLIP-seq
MIRT1969891	hsa-miR-199a-5p	CLIP-seq
MIRT1969892	hsa-miR-199b-5p	CLIP-seq
MIRT2509157	hsa-miR-3148	CLIP-seq
MIRT2509158	hsa-miR-3162-3p	CLIP-seq
MIRT2509161	hsa-miR-338-3p	CLIP-seq
MIRT2509166	hsa-miR-3978	CLIP-seq
MIRT2509168	hsa-miR-4520b-3p	CLIP-seq
MIRT2509169	hsa-miR-4529-3p	CLIP-seq
MIRT2509170	hsa-miR-4530	CLIP-seq
MIRT2509176	hsa-miR-561	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000245	Process	Spliceosomal complex assembly	IBA
GO:0000245	Process	Spliceosomal complex assembly	IDA	12084575
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000974	Component	Prp19 complex	IBA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	12084575
GO:0005515	Function	Protein binding	IPI	22365833, 33961781
GO:0005634	Component	Nucleus	IDA	28076346
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	11991638
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IBA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071014	Component	Post-mRNA release spliceosomal complex	IBA

Other IDs

• MIM: 610952
• HGNC: 15762
• e!Ensembl: ENSG00000101343

Protein

• UniProt ID: Q9BZJ0
• Protein name: Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)
• Protein function: Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:119916
• PDB: 5MQF , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6FF4 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6ZYM , 7A5P , 7ABI , 7DVQ , 7QTT , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8RO2 , 9FMD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02184	HAT	357 → 388	HAT (Half-A-TPR) repeat	Repeat
  PF02184	HAT	256 → 288	HAT (Half-A-TPR) repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575). {ECO:0000269|PubMed:11342225, ECO:0000269|PubMed:12084575}.
• Sequence:

  MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCAL
  DALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQ
  VPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVK
  NKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRT
  VISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD
  RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVD
  RARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFA
  KFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQY
  EEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINY
  ALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSI
  GKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRAR
  AIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFEL
  SSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPE
  KVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPD
  EDVDESES

• Sequence length: 848

Pathways

KEGG Pathway:

Spliceosome

Reactome Pathway:

mRNA Splicing - Major Pathway

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PQBP1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SMNDC1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. BCAS2 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SF3A1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. PPIH 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PQBP1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
SMNDC1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
BCAS2	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
SF3A1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
PPIH	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]

Diseases Linked via Similar Genes

Autism Linked via 2 of 5 related genesPQBP1, BCAS2 Atrial septal defect Linked via 1 of 5 related genesPQBP1 Growth disorder Linked via 1 of 5 related genesPQBP1 Congenital heart septal defect Linked via 1 of 5 related genesPQBP1 Intellectual developmental disorder Linked via 1 of 5 related genesPQBP1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Autism	2	["PQBP1","BCAS2"]
Atrial septal defect	1	["PQBP1"]
Growth disorder	1	["PQBP1"]
Congenital heart septal defect	1	["PQBP1"]
Intellectual developmental disorder	1	["PQBP1"]