Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51241
Gene name	Cytochrome c oxidase assembly factor COX16
Gene symbol	COX16
Synonyms (NCBI Gene)	C14orf112HSPC203MC4DN22hCOX16
Chromosome	14
Chromosome location	14q24.2

192 Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051611	hsa-let-7e-5p	CLASH	23622248
MIRT905028	hsa-miR-1204	CLIP-seq
MIRT905029	hsa-miR-1228	CLIP-seq
MIRT905030	hsa-miR-1323	CLIP-seq
MIRT905031	hsa-miR-1827	CLIP-seq
MIRT905032	hsa-miR-2114	CLIP-seq
MIRT905033	hsa-miR-23a	CLIP-seq
MIRT905034	hsa-miR-23b	CLIP-seq
MIRT905035	hsa-miR-23c	CLIP-seq
MIRT905036	hsa-miR-24	CLIP-seq
MIRT905037	hsa-miR-342-3p	CLIP-seq
MIRT905038	hsa-miR-3613-3p	CLIP-seq
MIRT905039	hsa-miR-3662	CLIP-seq
MIRT905040	hsa-miR-3664-3p	CLIP-seq
MIRT905041	hsa-miR-3664-5p	CLIP-seq
MIRT905042	hsa-miR-3675-3p	CLIP-seq
MIRT905043	hsa-miR-3926	CLIP-seq
MIRT905044	hsa-miR-4284	CLIP-seq
MIRT905045	hsa-miR-4428	CLIP-seq
MIRT905046	hsa-miR-4522	CLIP-seq
MIRT905047	hsa-miR-4649-3p	CLIP-seq
MIRT905048	hsa-miR-4663	CLIP-seq
MIRT905049	hsa-miR-4665-3p	CLIP-seq
MIRT905050	hsa-miR-4684-5p	CLIP-seq
MIRT905051	hsa-miR-4704-5p	CLIP-seq
MIRT905052	hsa-miR-4722-5p	CLIP-seq
MIRT905053	hsa-miR-4728-3p	CLIP-seq
MIRT905054	hsa-miR-4755-3p	CLIP-seq
MIRT905055	hsa-miR-4775	CLIP-seq
MIRT905056	hsa-miR-510	CLIP-seq
MIRT905057	hsa-miR-512-5p	CLIP-seq
MIRT905058	hsa-miR-514	CLIP-seq
MIRT905059	hsa-miR-514b-3p	CLIP-seq
MIRT905060	hsa-miR-548o	CLIP-seq
MIRT905061	hsa-miR-548s	CLIP-seq
MIRT905062	hsa-miR-549	CLIP-seq
MIRT905063	hsa-miR-550a	CLIP-seq
MIRT905064	hsa-miR-590-3p	CLIP-seq
MIRT905065	hsa-miR-940	CLIP-seq
MIRT905028	hsa-miR-1204	CLIP-seq
MIRT905029	hsa-miR-1228	CLIP-seq
MIRT1968425	hsa-miR-145	CLIP-seq
MIRT905043	hsa-miR-3926	CLIP-seq
MIRT1968426	hsa-miR-4436b-5p	CLIP-seq
MIRT1968427	hsa-miR-4476	CLIP-seq
MIRT1968428	hsa-miR-4699-5p	CLIP-seq
MIRT905055	hsa-miR-4775	CLIP-seq
MIRT905061	hsa-miR-548s	CLIP-seq
MIRT905064	hsa-miR-590-3p	CLIP-seq
MIRT1968429	hsa-miR-656	CLIP-seq
MIRT905029	hsa-miR-1228	CLIP-seq
MIRT2204229	hsa-miR-1273e	CLIP-seq
MIRT905033	hsa-miR-23a	CLIP-seq
MIRT905034	hsa-miR-23b	CLIP-seq
MIRT905035	hsa-miR-23c	CLIP-seq
MIRT905036	hsa-miR-24	CLIP-seq
MIRT2204230	hsa-miR-3163	CLIP-seq
MIRT905037	hsa-miR-342-3p	CLIP-seq
MIRT2204231	hsa-miR-3591-5p	CLIP-seq
MIRT2204232	hsa-miR-3606	CLIP-seq
MIRT2204233	hsa-miR-3692	CLIP-seq
MIRT2204234	hsa-miR-371-5p	CLIP-seq
MIRT2204235	hsa-miR-371b-5p	CLIP-seq
MIRT2204236	hsa-miR-3927	CLIP-seq
MIRT905044	hsa-miR-4284	CLIP-seq
MIRT2204237	hsa-miR-4310	CLIP-seq
MIRT2204238	hsa-miR-4318	CLIP-seq
MIRT1968426	hsa-miR-4436b-5p	CLIP-seq
MIRT2204239	hsa-miR-4486	CLIP-seq
MIRT2204240	hsa-miR-4649-5p	CLIP-seq
MIRT2204241	hsa-miR-4650-3p	CLIP-seq
MIRT905049	hsa-miR-4665-3p	CLIP-seq
MIRT2204242	hsa-miR-4693-5p	CLIP-seq
MIRT2204243	hsa-miR-4698	CLIP-seq
MIRT905054	hsa-miR-4755-3p	CLIP-seq
MIRT2204244	hsa-miR-4793-3p	CLIP-seq
MIRT2204245	hsa-miR-486-5p	CLIP-seq
MIRT2204246	hsa-miR-508-5p	CLIP-seq
MIRT2204247	hsa-miR-513c	CLIP-seq
MIRT2204248	hsa-miR-514b-5p	CLIP-seq
MIRT2204249	hsa-miR-548ac	CLIP-seq
MIRT2204250	hsa-miR-548ae	CLIP-seq
MIRT2204251	hsa-miR-548aj	CLIP-seq
MIRT2204252	hsa-miR-548am	CLIP-seq
MIRT2204253	hsa-miR-548d-3p	CLIP-seq
MIRT2204254	hsa-miR-548x	CLIP-seq
MIRT2204255	hsa-miR-548z	CLIP-seq
MIRT2204256	hsa-miR-649	CLIP-seq
MIRT2204257	hsa-miR-661	CLIP-seq
MIRT2204258	hsa-miR-766	CLIP-seq
MIRT2204259	hsa-miR-892a	CLIP-seq
MIRT2204260	hsa-miR-921	CLIP-seq
MIRT905033	hsa-miR-23a	CLIP-seq
MIRT905034	hsa-miR-23b	CLIP-seq
MIRT905035	hsa-miR-23c	CLIP-seq
MIRT905032	hsa-miR-2114	CLIP-seq
MIRT905040	hsa-miR-3664-3p	CLIP-seq
MIRT905042	hsa-miR-3675-3p	CLIP-seq
MIRT2465102	hsa-miR-455-5p	CLIP-seq
MIRT905048	hsa-miR-4663	CLIP-seq
MIRT905050	hsa-miR-4684-5p	CLIP-seq
MIRT905053	hsa-miR-4728-3p	CLIP-seq
MIRT905056	hsa-miR-510	CLIP-seq
MIRT905057	hsa-miR-512-5p	CLIP-seq
MIRT905063	hsa-miR-550a	CLIP-seq
MIRT905028	hsa-miR-1204	CLIP-seq
MIRT905029	hsa-miR-1228	CLIP-seq
MIRT2507826	hsa-miR-1270	CLIP-seq
MIRT2507827	hsa-miR-1273f	CLIP-seq
MIRT2507828	hsa-miR-1294	CLIP-seq
MIRT905031	hsa-miR-1827	CLIP-seq
MIRT2507829	hsa-miR-2053	CLIP-seq
MIRT2507830	hsa-miR-2054	CLIP-seq
MIRT905033	hsa-miR-23a	CLIP-seq
MIRT905034	hsa-miR-23b	CLIP-seq
MIRT905035	hsa-miR-23c	CLIP-seq
MIRT2507831	hsa-miR-2681	CLIP-seq
MIRT2507832	hsa-miR-3607-5p	CLIP-seq
MIRT905038	hsa-miR-3613-3p	CLIP-seq
MIRT2507833	hsa-miR-3650	CLIP-seq
MIRT905041	hsa-miR-3664-5p	CLIP-seq
MIRT905042	hsa-miR-3675-3p	CLIP-seq
MIRT2507834	hsa-miR-3920	CLIP-seq
MIRT905043	hsa-miR-3926	CLIP-seq
MIRT2507835	hsa-miR-3974	CLIP-seq
MIRT2507836	hsa-miR-4289	CLIP-seq
MIRT2507837	hsa-miR-4316	CLIP-seq
MIRT2507838	hsa-miR-4433	CLIP-seq
MIRT2507839	hsa-miR-4457	CLIP-seq
MIRT2507840	hsa-miR-4459	CLIP-seq
MIRT2507841	hsa-miR-4499	CLIP-seq
MIRT2507842	hsa-miR-4501	CLIP-seq
MIRT905046	hsa-miR-4522	CLIP-seq
MIRT2507843	hsa-miR-4531	CLIP-seq
MIRT2507844	hsa-miR-4534	CLIP-seq
MIRT905050	hsa-miR-4684-5p	CLIP-seq
MIRT905052	hsa-miR-4722-5p	CLIP-seq
MIRT2507845	hsa-miR-4768-3p	CLIP-seq
MIRT2507846	hsa-miR-4786-5p	CLIP-seq
MIRT2507847	hsa-miR-4790-3p	CLIP-seq
MIRT2507848	hsa-miR-4793-5p	CLIP-seq
MIRT2507849	hsa-miR-4794	CLIP-seq
MIRT2507850	hsa-miR-487a	CLIP-seq
MIRT2507851	hsa-miR-513b	CLIP-seq
MIRT2507852	hsa-miR-520d-5p	CLIP-seq
MIRT2507853	hsa-miR-524-5p	CLIP-seq
MIRT2507854	hsa-miR-541	CLIP-seq
MIRT905061	hsa-miR-548s	CLIP-seq
MIRT2507855	hsa-miR-569	CLIP-seq
MIRT2507856	hsa-miR-620	CLIP-seq
MIRT2507857	hsa-miR-624	CLIP-seq
MIRT2507858	hsa-miR-654-5p	CLIP-seq
MIRT2507859	hsa-miR-758	CLIP-seq
MIRT905065	hsa-miR-940	CLIP-seq
MIRT2507860	hsa-miR-944	CLIP-seq
MIRT905029	hsa-miR-1228	CLIP-seq
MIRT2507827	hsa-miR-1273f	CLIP-seq
MIRT2507828	hsa-miR-1294	CLIP-seq
MIRT905031	hsa-miR-1827	CLIP-seq
MIRT2507829	hsa-miR-2053	CLIP-seq
MIRT2507830	hsa-miR-2054	CLIP-seq
MIRT905033	hsa-miR-23a	CLIP-seq
MIRT905034	hsa-miR-23b	CLIP-seq
MIRT905035	hsa-miR-23c	CLIP-seq
MIRT2507831	hsa-miR-2681	CLIP-seq
MIRT905038	hsa-miR-3613-3p	CLIP-seq
MIRT2507833	hsa-miR-3650	CLIP-seq
MIRT905041	hsa-miR-3664-5p	CLIP-seq
MIRT905042	hsa-miR-3675-3p	CLIP-seq
MIRT2507835	hsa-miR-3974	CLIP-seq
MIRT2507836	hsa-miR-4289	CLIP-seq
MIRT2507837	hsa-miR-4316	CLIP-seq
MIRT2507838	hsa-miR-4433	CLIP-seq
MIRT2507839	hsa-miR-4457	CLIP-seq
MIRT2507840	hsa-miR-4459	CLIP-seq
MIRT905046	hsa-miR-4522	CLIP-seq
MIRT2507844	hsa-miR-4534	CLIP-seq
MIRT905050	hsa-miR-4684-5p	CLIP-seq
MIRT905052	hsa-miR-4722-5p	CLIP-seq
MIRT2507845	hsa-miR-4768-3p	CLIP-seq
MIRT2507846	hsa-miR-4786-5p	CLIP-seq
MIRT2507847	hsa-miR-4790-3p	CLIP-seq
MIRT2507848	hsa-miR-4793-5p	CLIP-seq
MIRT2507849	hsa-miR-4794	CLIP-seq
MIRT2507851	hsa-miR-513b	CLIP-seq
MIRT2507854	hsa-miR-541	CLIP-seq
MIRT2507855	hsa-miR-569	CLIP-seq
MIRT2507857	hsa-miR-624	CLIP-seq
MIRT2507858	hsa-miR-654-5p	CLIP-seq
MIRT2507859	hsa-miR-758	CLIP-seq
MIRT905065	hsa-miR-940	CLIP-seq
MIRT2507860	hsa-miR-944	CLIP-seq

13 Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	29355485, 29381136, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	29355485, 29381136
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IBA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IDA	29381136
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IMP	29355485

MIM	HGNC	e!Ensembl
618064	20213	ENSG00000133983

Q9P0S2

Protein name

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (hCOX16)

Protein function

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136, PubMed:33169484). Promotes the insertion of copper into the active site of cytochrome c oxid

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14138	COX16	16 → 88	Cytochrome c oxidase assembly protein COX16	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in skeletal muscle, heart and liver. {ECO:0000269|PubMed:29355485}.

Sequence

MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENK
ISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT

Sequence length

106

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Thermogenesis	TP53 Regulates Metabolic Genes
	Respiratory electron transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Mitochondrial complex IV deficiency, nuclear type 22	Pathogenic	rs781059799	RCV001449913	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
mitochondrial disease	—	ClinGen	ClinGen report	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	37094658	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	33398198, 37340002, 37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	33398198, 37340002, 37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (8)
Acidosis Lactic	Lactic acidosis	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Hypertrophic cardiomyopathy	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome c Oxidase Deficiency	Cytochrome c oxidase deficiency	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	BEFREE	15596615		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	33169484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
COX11	3	["Mitochondrial complex deficiency","Mitochondrial disease","Obsessive-compulsive disorder"]	3	["Thermogenesis","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	5	["ClinVar (Mitochondrial complex deficiency)","Disgenet (Mitochondrial complex deficiency)","HPO (Mitochondrial complex deficiency)","ClinGen (Mitochondrial disease)","GWAS catalog (Obsessive-compulsive disorder)"]
COA8	3	["Mitochondrial complex deficiency","Mitochondrial disease","Obsessive-compulsive disorder"]	0	[]	5	["ClinVar (Mitochondrial complex deficiency)","Disgenet (Mitochondrial complex deficiency)","HPO (Mitochondrial complex deficiency)","ClinGen (Mitochondrial disease)","GWAS catalog (Obsessive-compulsive disorder)"]
COX20	2	["Mitochondrial complex deficiency","Mitochondrial disease"]	3	["Thermogenesis","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	4	["ClinVar (Mitochondrial complex deficiency)","Disgenet (Mitochondrial complex deficiency)","HPO (Mitochondrial complex deficiency)","ClinGen (Mitochondrial disease)"]
COX14	2	["Mitochondrial complex deficiency","Mitochondrial disease"]	3	["Thermogenesis","TP53 Regulates Metabolic Genes","Respiratory electron transport"]	4	["ClinVar (Mitochondrial complex deficiency)","Disgenet (Mitochondrial complex deficiency)","HPO (Mitochondrial complex deficiency)","ClinGen (Mitochondrial disease)"]
UQCRH	2	["Mitochondrial complex deficiency","Mitochondrial disease"]	2	["Thermogenesis","Respiratory electron transport"]	4	["ClinVar (Mitochondrial complex deficiency)","Disgenet (Mitochondrial complex deficiency)","HPO (Mitochondrial complex deficiency)","ClinGen (Mitochondrial disease)"]

COX16 (cytochrome c oxidase assembly factor COX16)

Bookmark This Gene