Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51138
Gene name	COP9 signalosome subunit 4
Gene symbol	COPS4
Synonyms (NCBI Gene)	CSN4SGN4
Chromosome	4
Chromosome location	4q21.22
Summary	This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S re

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miRTarBase ID	miRNA	Experiments	Reference
MIRT440909	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT440907	hsa-miR-136-3p	HITS-CLIP	24374217
MIRT440909	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT440907	hsa-miR-136-3p	HITS-CLIP	24374217
MIRT904043	hsa-miR-1292	CLIP-seq
MIRT904044	hsa-miR-1322	CLIP-seq
MIRT904045	hsa-miR-191	CLIP-seq
MIRT904046	hsa-miR-203	CLIP-seq
MIRT904047	hsa-miR-3074-5p	CLIP-seq
MIRT904048	hsa-miR-338-3p	CLIP-seq
MIRT904049	hsa-miR-370	CLIP-seq
MIRT904050	hsa-miR-3974	CLIP-seq
MIRT904051	hsa-miR-433	CLIP-seq
MIRT904052	hsa-miR-4471	CLIP-seq
MIRT904053	hsa-miR-4530	CLIP-seq
MIRT904054	hsa-miR-4725-5p	CLIP-seq
MIRT904055	hsa-miR-4778-3p	CLIP-seq
MIRT904056	hsa-miR-504	CLIP-seq
MIRT904057	hsa-miR-553	CLIP-seq
MIRT904058	hsa-miR-568	CLIP-seq
MIRT904047	hsa-miR-3074-5p	CLIP-seq
MIRT904049	hsa-miR-370	CLIP-seq
MIRT904055	hsa-miR-4778-3p	CLIP-seq
MIRT904057	hsa-miR-553	CLIP-seq
MIRT2203920	hsa-miR-105	CLIP-seq
MIRT2203921	hsa-miR-1270	CLIP-seq
MIRT904044	hsa-miR-1322	CLIP-seq
MIRT904045	hsa-miR-191	CLIP-seq
MIRT904046	hsa-miR-203	CLIP-seq
MIRT2203922	hsa-miR-3145-3p	CLIP-seq
MIRT904048	hsa-miR-338-3p	CLIP-seq
MIRT904050	hsa-miR-3974	CLIP-seq
MIRT904051	hsa-miR-433	CLIP-seq
MIRT904053	hsa-miR-4530	CLIP-seq
MIRT2203923	hsa-miR-4531	CLIP-seq
MIRT2203924	hsa-miR-4666-5p	CLIP-seq
MIRT2203925	hsa-miR-4683	CLIP-seq
MIRT904055	hsa-miR-4778-3p	CLIP-seq
MIRT904057	hsa-miR-553	CLIP-seq
MIRT904058	hsa-miR-568	CLIP-seq
MIRT2203926	hsa-miR-620	CLIP-seq
MIRT904043	hsa-miR-1292	CLIP-seq
MIRT904045	hsa-miR-191	CLIP-seq
MIRT904047	hsa-miR-3074-5p	CLIP-seq
MIRT904048	hsa-miR-338-3p	CLIP-seq
MIRT904049	hsa-miR-370	CLIP-seq
MIRT904052	hsa-miR-4471	CLIP-seq
MIRT904053	hsa-miR-4530	CLIP-seq
MIRT904054	hsa-miR-4725-5p	CLIP-seq
MIRT904055	hsa-miR-4778-3p	CLIP-seq
MIRT904056	hsa-miR-504	CLIP-seq
MIRT904057	hsa-miR-553	CLIP-seq
MIRT904043	hsa-miR-1292	CLIP-seq
MIRT904045	hsa-miR-191	CLIP-seq
MIRT904047	hsa-miR-3074-5p	CLIP-seq
MIRT904048	hsa-miR-338-3p	CLIP-seq
MIRT904049	hsa-miR-370	CLIP-seq
MIRT904052	hsa-miR-4471	CLIP-seq
MIRT904053	hsa-miR-4530	CLIP-seq
MIRT904054	hsa-miR-4725-5p	CLIP-seq
MIRT904055	hsa-miR-4778-3p	CLIP-seq
MIRT904056	hsa-miR-504	CLIP-seq
MIRT904057	hsa-miR-553	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0000338	Process	Protein deneddylation	IMP	21102408
GO:0005515	Function	Protein binding	IPI	16189514, 19615732, 20195357, 21102408, 21145461, 25043011, 25416956, 25852190, 26030138, 26871637, 28514442, 32296183, 32707033, 32814053, 33961781, 34591612
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	24421388
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24421388
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0008021	Component	Synaptic vesicle	IDA	21102408
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008180	Component	COP9 signalosome	IBA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0008180	Component	COP9 signalosome	IEA
GO:0008180	Component	COP9 signalosome	IPI	25043011
GO:0008180	Component	COP9 signalosome	ISS
GO:0016607	Component	Nuclear speck	IDA
GO:0019784	Function	DeNEDDylase activity	TAS
GO:0030054	Component	Cell junction	IDA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0045116	Process	Protein neddylation	NAS	24421388
GO:0045202	Component	Synapse	IEA
GO:2000434	Process	Regulation of protein neddylation	NAS	24421388

MIM	HGNC	e!Ensembl
616008	16702	ENSG00000138663

Q9BT78

Protein name

COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)

Protein function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the culli

PDB

4D0P , 4D10 , 4D18 , 4WSN , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 8H38 , 8H3A , 8H3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01399	PCI	264 → 363	PCI domain	Domain
PF18420	CSN4_RPN5_eIF3a	365 → 406	CSN4/RPN5/eIF3a helix turn helix domain	Domain

Sequence

MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLV
ISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDW
RNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTN
EQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQ
QRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSIL
DRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVH
FETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ

Sequence length

406

Interactions

View interactions

Reactome Pathway
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation

COPS4 (COP9 signalosome subunit 4)

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