CNGA2 (cyclic nucleotide gated channel subunit alpha 2)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1260
• Gene name: Cyclic nucleotide gated channel subunit alpha 2
• Gene symbol: CNGA2
• Synonyms (NCBI Gene): CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa
• Chromosome: X
• Chromosome location: Xq28
• Summary: The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

miRNA Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	22291592
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	22291592
MIRT495164	hsa-miR-204-3p	PAR-CLIP	22291592
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	22291592
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	22291592
MIRT495161	hsa-miR-619-5p	PAR-CLIP	22291592
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	22291592
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	22291592
MIRT495158	hsa-miR-638	PAR-CLIP	22291592
MIRT495156	hsa-miR-4314	PAR-CLIP	22291592
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	22291592
MIRT495155	hsa-miR-769-3p	PAR-CLIP	22291592
MIRT495166	hsa-miR-4753-5p	PAR-CLIP	23708386
MIRT495165	hsa-miR-3922-5p	PAR-CLIP	23708386
MIRT495164	hsa-miR-204-3p	PAR-CLIP	23708386
MIRT495163	hsa-miR-4646-5p	PAR-CLIP	23708386
MIRT495162	hsa-miR-3192-5p	PAR-CLIP	23708386
MIRT495161	hsa-miR-619-5p	PAR-CLIP	23708386
MIRT495160	hsa-miR-6506-5p	PAR-CLIP	23708386
MIRT495159	hsa-miR-4713-3p	PAR-CLIP	23708386
MIRT495158	hsa-miR-638	PAR-CLIP	23708386
MIRT495156	hsa-miR-4314	PAR-CLIP	23708386
MIRT495157	hsa-miR-450b-3p	PAR-CLIP	23708386
MIRT495155	hsa-miR-769-3p	PAR-CLIP	23708386
MIRT899513	hsa-miR-1251	CLIP-seq
MIRT899514	hsa-miR-125a-5p	CLIP-seq
MIRT899515	hsa-miR-125b	CLIP-seq
MIRT899516	hsa-miR-200b	CLIP-seq
MIRT899517	hsa-miR-200c	CLIP-seq
MIRT899518	hsa-miR-3126-5p	CLIP-seq
MIRT899519	hsa-miR-3192	CLIP-seq
MIRT899520	hsa-miR-4268	CLIP-seq
MIRT899521	hsa-miR-429	CLIP-seq
MIRT899522	hsa-miR-4319	CLIP-seq
MIRT899523	hsa-miR-4419a	CLIP-seq
MIRT899524	hsa-miR-4502	CLIP-seq
MIRT899525	hsa-miR-4510	CLIP-seq
MIRT899526	hsa-miR-4732-3p	CLIP-seq
MIRT899527	hsa-miR-670	CLIP-seq
MIRT1966822	hsa-miR-4270	CLIP-seq
MIRT1966823	hsa-miR-4441	CLIP-seq
MIRT2202596	hsa-miR-139-5p	CLIP-seq
MIRT2202597	hsa-miR-2278	CLIP-seq
MIRT2202598	hsa-miR-28-5p	CLIP-seq
MIRT2202599	hsa-miR-3139	CLIP-seq
MIRT2202600	hsa-miR-4722-5p	CLIP-seq
MIRT2202601	hsa-miR-4797-5p	CLIP-seq
MIRT2202602	hsa-miR-708	CLIP-seq
MIRT2386273	hsa-miR-3120-5p	CLIP-seq
MIRT2386274	hsa-miR-3138	CLIP-seq
MIRT2386275	hsa-miR-3925-3p	CLIP-seq
MIRT2386276	hsa-miR-766	CLIP-seq
MIRT2447291	hsa-miR-622	CLIP-seq

Gene ontology (GO) Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005221	Function	Intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IEA
GO:0005222	Function	Intracellularly cAMP-activated cation channel activity	IBA
GO:0005223	Function	Intracellularly cGMP-activated cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	ISS
GO:0006814	Process	Sodium ion transport	ISS
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	ISS
GO:0007606	Process	Sensory perception of chemical stimulus	IBA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016020	Component	Membrane	IEA
GO:0017071	Component	Intracellular cyclic nucleotide activated cation channel complex	IBA
GO:0030552	Function	CAMP binding	IEA
GO:0030553	Function	CGMP binding	IBA
GO:0030553	Function	CGMP binding	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	TAS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042995	Component	Cell projection	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0060170	Component	Ciliary membrane	ISS
GO:0060170	Component	Ciliary membrane	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098655	Process	Monoatomic cation transmembrane transport	IBA
GO:0098804	Component	Non-motile cilium membrane	IEA
GO:0098804	Component	Non-motile cilium membrane	ISS

Other IDs

• MIM: 300338
• HGNC: 2149
• e!Ensembl: ENSG00000183862

Protein

• UniProt ID: Q16280
• Protein name: Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1)
• Protein function: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00027	cNMP_binding	472 → 563	Cyclic nucleotide-binding domain	Domain
  PF00520	Ion_trans	140 → 383	Ion transport protein	Family
  PF16526	CLZ	570 → 639	C-terminal leucine zipper domain of cyclic nucleotide-gated channels	Coiled-coil

• Sequence:

  MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
  QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
  DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
  VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
  HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
  GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
  VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
  KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
  ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
  RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
  LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
  ADEP

• Sequence length: 664

Pathways

KEGG Pathway	Reactome Pathway
cAMP signaling pathway	VxPx cargo-targeting to cilium
Olfactory transduction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANOSMIA	—	GenCC	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ANOSMIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Congenital anosmia	Congenital Anosmia	BEFREE	25156905, 28572688		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital anosmia	Congenital Anosmia	ORPHANET_DG	25156905		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital anosmia	Congenital anosmia	Pubtator	28572688, 38148624	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Isolated congenital anosmia	Isolated Congenital Anosmia	Orphanet			★☆☆☆☆ Found in Text Mining only
Kallmann Syndrome	Kallmann syndrome	Pubtator	28572688	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TENM1 2 shared diseasesAnosmia, Congenital anosmia 2 shared evidence sourcesGenCC (Anosmia), Disgenet (Congenital anosmia) Related via 2 shared diseases including Anosmia, Congenital anosmia — evidence mostly GenCC. CNGA4 2 shared pathwayscAMP signaling pathway, VxPx cargo-targeting to cilium Related via 2 shared pathways including cAMP signaling pathway, VxPx cargo-targeting to cilium. CNGB1 2 shared pathwayscAMP signaling pathway, VxPx cargo-targeting to cilium Related via 2 shared pathways including cAMP signaling pathway, VxPx cargo-targeting to cilium.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TENM1	2	["Anosmia","Congenital anosmia"]	0	[]	2	["GenCC (Anosmia)","Disgenet (Congenital anosmia)"]
CNGA4	0	[]	2	["cAMP signaling pathway","VxPx cargo-targeting to cilium"]	0	[]
CNGB1	0	[]	2	["cAMP signaling pathway","VxPx cargo-targeting to cilium"]	0	[]

Diseases Linked via Similar Genes

Cerebral palsy Linked via 1 of 3 related genesTENM1 Moyamoya angiopathy Linked via 1 of 3 related genesTENM1 Hearing loss Linked via 1 of 3 related genesTENM1 Duodenal ulcer Linked via 1 of 3 related genesCNGA4 Gastric ulcer Linked via 1 of 3 related genesCNGA4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Cerebral palsy	1	["TENM1"]
Moyamoya angiopathy	1	["TENM1"]
Hearing loss	1	["TENM1"]
Duodenal ulcer	1	["CNGA4"]
Gastric ulcer	1	["CNGA4"]