CKS1B (CDC28 protein kinase regulatory subunit 1B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1163
• Gene name: CDC28 protein kinase regulatory subunit 1B
• Gene symbol: CKS1B
• Synonyms (NCBI Gene): CKS1, PNAS-16, PNAS-18, ckshs1
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized r

miRNA Show/Hide all (229)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048080	hsa-miR-197-3p	CLASH	23622248
MIRT039329	hsa-miR-425-5p	CLASH	23622248
MIRT036562	hsa-miR-941	CLASH	23622248
MIRT448933	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT448934	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT448932	hsa-miR-320a	PAR-CLIP	22100165
MIRT448931	hsa-miR-320b	PAR-CLIP	22100165
MIRT448930	hsa-miR-320c	PAR-CLIP	22100165
MIRT448929	hsa-miR-320d	PAR-CLIP	22100165
MIRT448928	hsa-miR-4429	PAR-CLIP	22100165
MIRT448927	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450894	hsa-miR-8080	PAR-CLIP	22100165
MIRT450893	hsa-miR-6816-3p	PAR-CLIP	22100165
MIRT448926	hsa-miR-3929	PAR-CLIP	22100165
MIRT448925	hsa-miR-4419b	PAR-CLIP	22100165
MIRT448923	hsa-miR-4478	PAR-CLIP	22100165
MIRT448924	hsa-miR-3975	PAR-CLIP	22100165
MIRT448922	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT448921	hsa-miR-3188	PAR-CLIP	22100165
MIRT448920	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT448919	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT448918	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT448933	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT448934	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT448932	hsa-miR-320a	PAR-CLIP	22100165
MIRT448931	hsa-miR-320b	PAR-CLIP	22100165
MIRT448930	hsa-miR-320c	PAR-CLIP	22100165
MIRT448929	hsa-miR-320d	PAR-CLIP	22100165
MIRT448928	hsa-miR-4429	PAR-CLIP	22100165
MIRT448927	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT448926	hsa-miR-3929	PAR-CLIP	22100165
MIRT448925	hsa-miR-4419b	PAR-CLIP	22100165
MIRT448923	hsa-miR-4478	PAR-CLIP	22100165
MIRT448924	hsa-miR-3975	PAR-CLIP	22100165
MIRT448922	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT448921	hsa-miR-3188	PAR-CLIP	22100165
MIRT448920	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT448919	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT448918	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT448933	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT448934	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT448932	hsa-miR-320a	PAR-CLIP	22100165
MIRT448931	hsa-miR-320b	PAR-CLIP	22100165
MIRT448930	hsa-miR-320c	PAR-CLIP	22100165
MIRT448929	hsa-miR-320d	PAR-CLIP	22100165
MIRT448928	hsa-miR-4429	PAR-CLIP	22100165
MIRT448927	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450894	hsa-miR-8080	PAR-CLIP	22100165
MIRT450893	hsa-miR-6816-3p	PAR-CLIP	22100165
MIRT448926	hsa-miR-3929	PAR-CLIP	22100165
MIRT448925	hsa-miR-4419b	PAR-CLIP	22100165
MIRT448923	hsa-miR-4478	PAR-CLIP	22100165
MIRT448924	hsa-miR-3975	PAR-CLIP	22100165
MIRT448922	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT448921	hsa-miR-3188	PAR-CLIP	22100165
MIRT448920	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT448919	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT448918	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT448933	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT448934	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT448932	hsa-miR-320a	PAR-CLIP	22100165
MIRT448931	hsa-miR-320b	PAR-CLIP	22100165
MIRT448930	hsa-miR-320c	PAR-CLIP	22100165
MIRT448929	hsa-miR-320d	PAR-CLIP	22100165
MIRT448928	hsa-miR-4429	PAR-CLIP	22100165
MIRT448927	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT448926	hsa-miR-3929	PAR-CLIP	22100165
MIRT448925	hsa-miR-4419b	PAR-CLIP	22100165
MIRT448923	hsa-miR-4478	PAR-CLIP	22100165
MIRT448924	hsa-miR-3975	PAR-CLIP	22100165
MIRT448922	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT448921	hsa-miR-3188	PAR-CLIP	22100165
MIRT448920	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT448919	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT448918	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT048080	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA-seq	36132985
MIRT048080	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	36132985
MIRT894248	hsa-miR-1204	CLIP-seq
MIRT894249	hsa-miR-145	CLIP-seq
MIRT894250	hsa-miR-181a	CLIP-seq
MIRT894251	hsa-miR-181b	CLIP-seq
MIRT894252	hsa-miR-181c	CLIP-seq
MIRT894253	hsa-miR-181d	CLIP-seq
MIRT894254	hsa-miR-197	CLIP-seq
MIRT894255	hsa-miR-224	CLIP-seq
MIRT894256	hsa-miR-3120-3p	CLIP-seq
MIRT894257	hsa-miR-3148	CLIP-seq
MIRT894258	hsa-miR-3163	CLIP-seq
MIRT894259	hsa-miR-3180-5p	CLIP-seq
MIRT894260	hsa-miR-330-3p	CLIP-seq
MIRT894261	hsa-miR-3609	CLIP-seq
MIRT894262	hsa-miR-3662	CLIP-seq
MIRT894263	hsa-miR-3688-3p	CLIP-seq
MIRT894264	hsa-miR-3973	CLIP-seq
MIRT894265	hsa-miR-3978	CLIP-seq
MIRT894266	hsa-miR-4262	CLIP-seq
MIRT894267	hsa-miR-4314	CLIP-seq
MIRT894268	hsa-miR-4667-5p	CLIP-seq
MIRT894269	hsa-miR-4694-3p	CLIP-seq
MIRT894270	hsa-miR-4700-5p	CLIP-seq
MIRT894271	hsa-miR-4712-5p	CLIP-seq
MIRT894272	hsa-miR-4789-3p	CLIP-seq
MIRT894273	hsa-miR-4803	CLIP-seq
MIRT894274	hsa-miR-520g	CLIP-seq
MIRT894275	hsa-miR-520h	CLIP-seq
MIRT894276	hsa-miR-539	CLIP-seq
MIRT894277	hsa-miR-548ah	CLIP-seq
MIRT894278	hsa-miR-561	CLIP-seq
MIRT894279	hsa-miR-605	CLIP-seq
MIRT894280	hsa-miR-615-5p	CLIP-seq
MIRT894281	hsa-miR-634	CLIP-seq
MIRT894282	hsa-miR-637	CLIP-seq
MIRT894283	hsa-miR-770-5p	CLIP-seq
MIRT894284	hsa-miR-935	CLIP-seq
MIRT1965153	hsa-miR-1304	CLIP-seq
MIRT894249	hsa-miR-145	CLIP-seq
MIRT1965154	hsa-miR-149	CLIP-seq
MIRT894250	hsa-miR-181a	CLIP-seq
MIRT894251	hsa-miR-181b	CLIP-seq
MIRT894252	hsa-miR-181c	CLIP-seq
MIRT894253	hsa-miR-181d	CLIP-seq
MIRT894255	hsa-miR-224	CLIP-seq
MIRT1965155	hsa-miR-3064-5p	CLIP-seq
MIRT1965156	hsa-miR-3126-3p	CLIP-seq
MIRT894259	hsa-miR-3180-5p	CLIP-seq
MIRT1965157	hsa-miR-323-5p	CLIP-seq
MIRT894261	hsa-miR-3609	CLIP-seq
MIRT1965158	hsa-miR-3652	CLIP-seq
MIRT1965159	hsa-miR-378g	CLIP-seq
MIRT894264	hsa-miR-3973	CLIP-seq
MIRT894266	hsa-miR-4262	CLIP-seq
MIRT1965160	hsa-miR-4430	CLIP-seq
MIRT1965161	hsa-miR-4505	CLIP-seq
MIRT894271	hsa-miR-4712-5p	CLIP-seq
MIRT1965162	hsa-miR-4794	CLIP-seq
MIRT894273	hsa-miR-4803	CLIP-seq
MIRT1965163	hsa-miR-494	CLIP-seq
MIRT894274	hsa-miR-520g	CLIP-seq
MIRT894275	hsa-miR-520h	CLIP-seq
MIRT894276	hsa-miR-539	CLIP-seq
MIRT894277	hsa-miR-548ah	CLIP-seq
MIRT1965164	hsa-miR-548n	CLIP-seq
MIRT894279	hsa-miR-605	CLIP-seq
MIRT894281	hsa-miR-634	CLIP-seq
MIRT894283	hsa-miR-770-5p	CLIP-seq
MIRT1965165	hsa-miR-876-3p	CLIP-seq
MIRT894284	hsa-miR-935	CLIP-seq
MIRT2201136	hsa-miR-1258	CLIP-seq
MIRT1965153	hsa-miR-1304	CLIP-seq
MIRT894250	hsa-miR-181a	CLIP-seq
MIRT894251	hsa-miR-181b	CLIP-seq
MIRT894252	hsa-miR-181c	CLIP-seq
MIRT894253	hsa-miR-181d	CLIP-seq
MIRT2201137	hsa-miR-194	CLIP-seq
MIRT894254	hsa-miR-197	CLIP-seq
MIRT894255	hsa-miR-224	CLIP-seq
MIRT894256	hsa-miR-3120-3p	CLIP-seq
MIRT894257	hsa-miR-3148	CLIP-seq
MIRT894260	hsa-miR-330-3p	CLIP-seq
MIRT2201138	hsa-miR-339-5p	CLIP-seq
MIRT894261	hsa-miR-3609	CLIP-seq
MIRT2201139	hsa-miR-361-5p	CLIP-seq
MIRT2201140	hsa-miR-371-5p	CLIP-seq
MIRT2201141	hsa-miR-371b-5p	CLIP-seq
MIRT894264	hsa-miR-3973	CLIP-seq
MIRT2201142	hsa-miR-409-3p	CLIP-seq
MIRT894266	hsa-miR-4262	CLIP-seq
MIRT2201143	hsa-miR-4476	CLIP-seq
MIRT2201144	hsa-miR-4666-5p	CLIP-seq
MIRT894268	hsa-miR-4667-5p	CLIP-seq
MIRT894270	hsa-miR-4700-5p	CLIP-seq
MIRT894272	hsa-miR-4789-3p	CLIP-seq
MIRT894273	hsa-miR-4803	CLIP-seq
MIRT1965163	hsa-miR-494	CLIP-seq
MIRT2201145	hsa-miR-512-5p	CLIP-seq
MIRT894274	hsa-miR-520g	CLIP-seq
MIRT894275	hsa-miR-520h	CLIP-seq
MIRT894276	hsa-miR-539	CLIP-seq
MIRT894277	hsa-miR-548ah	CLIP-seq
MIRT1965164	hsa-miR-548n	CLIP-seq
MIRT894279	hsa-miR-605	CLIP-seq
MIRT894280	hsa-miR-615-5p	CLIP-seq
MIRT894281	hsa-miR-634	CLIP-seq
MIRT894282	hsa-miR-637	CLIP-seq
MIRT894284	hsa-miR-935	CLIP-seq
MIRT2503898	hsa-miR-1245b-3p	CLIP-seq
MIRT2201137	hsa-miR-194	CLIP-seq
MIRT894254	hsa-miR-197	CLIP-seq
MIRT2503899	hsa-miR-2115	CLIP-seq
MIRT894255	hsa-miR-224	CLIP-seq
MIRT894256	hsa-miR-3120-3p	CLIP-seq
MIRT894257	hsa-miR-3148	CLIP-seq
MIRT2201138	hsa-miR-339-5p	CLIP-seq
MIRT2201140	hsa-miR-371-5p	CLIP-seq
MIRT2201141	hsa-miR-371b-5p	CLIP-seq
MIRT2503900	hsa-miR-4330	CLIP-seq
MIRT2503901	hsa-miR-4480	CLIP-seq
MIRT2201144	hsa-miR-4666-5p	CLIP-seq
MIRT2503902	hsa-miR-4691-5p	CLIP-seq
MIRT2503903	hsa-miR-4727-5p	CLIP-seq
MIRT2503904	hsa-miR-4769-3p	CLIP-seq
MIRT894272	hsa-miR-4789-3p	CLIP-seq
MIRT894273	hsa-miR-4803	CLIP-seq
MIRT1965163	hsa-miR-494	CLIP-seq
MIRT2503905	hsa-miR-516a-3p	CLIP-seq
MIRT2503906	hsa-miR-595	CLIP-seq
MIRT894279	hsa-miR-605	CLIP-seq
MIRT2503898	hsa-miR-1245b-3p	CLIP-seq
MIRT2201137	hsa-miR-194	CLIP-seq
MIRT894254	hsa-miR-197	CLIP-seq
MIRT2503899	hsa-miR-2115	CLIP-seq
MIRT894255	hsa-miR-224	CLIP-seq
MIRT894256	hsa-miR-3120-3p	CLIP-seq
MIRT894257	hsa-miR-3148	CLIP-seq
MIRT2201138	hsa-miR-339-5p	CLIP-seq
MIRT2201140	hsa-miR-371-5p	CLIP-seq
MIRT2201141	hsa-miR-371b-5p	CLIP-seq
MIRT2503900	hsa-miR-4330	CLIP-seq
MIRT2503901	hsa-miR-4480	CLIP-seq
MIRT2201144	hsa-miR-4666-5p	CLIP-seq
MIRT2503902	hsa-miR-4691-5p	CLIP-seq
MIRT2503903	hsa-miR-4727-5p	CLIP-seq
MIRT2503904	hsa-miR-4769-3p	CLIP-seq
MIRT894272	hsa-miR-4789-3p	CLIP-seq
MIRT894273	hsa-miR-4803	CLIP-seq
MIRT1965163	hsa-miR-494	CLIP-seq
MIRT2503905	hsa-miR-516a-3p	CLIP-seq
MIRT2503906	hsa-miR-595	CLIP-seq
MIRT894279	hsa-miR-605	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA
GO:0005515	Function	Protein binding	IPI	2227411, 8601310, 9840943, 12813041, 16209941, 18239684, 23455922, 23602568, 25416956, 25852190, 26496610, 28514442, 29997244, 31467278, 31515488, 32296183, 32707033, 33961781, 35016035, 35512704, 37398436
GO:0005654	Component	Nucleoplasm	TAS
GO:0007346	Process	Regulation of mitotic cell cycle	IBA
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019901	Function	Protein kinase binding	IBA
GO:0042393	Function	Histone binding	IBA
GO:0043130	Function	Ubiquitin binding	IBA
GO:0051301	Process	Cell division	IEA
GO:0061575	Function	Cyclin-dependent protein serine/threonine kinase activator activity	IBA

Other IDs

• MIM: 116900
• HGNC: 19083
• e!Ensembl: ENSG00000173207

Protein

• UniProt ID: P61024
• Protein name: Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
• Protein function: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
• PDB: 1BUH , 1DKS , 1DKT , 2ASS , 2AST , 4YC6 , 7B5L , 7B5M , 7B5R , 7NJ0 , 8BYA , 8BYL , 8OR0 , 8OR4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01111	CKS	6 → 73	Cyclin-dependent kinase regulatory subunit	Domain

• Sequence:

  MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH
  EPEPHILLFRRPLPKKPKK

• Sequence length: 79

Pathways

KEGG Pathway	Reactome Pathway
Pathways in cancer	SCF(Skp2)-mediated degradation of p27/p21
Small cell lung cancer	Cyclin D associated events in G1

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SKP2 3 shared pathwaysSmall cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21, Cyclin D associated events in G1 Related via 3 shared pathways including Small cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21. PTK6 2 shared pathwaysSCF(Skp2)-mediated degradation of p27/p21, Cyclin D associated events in G1 Related via 2 shared pathways including SCF(Skp2)-mediated degradation of p27/p21, Cyclin D associated events in G1. CDKN2B 2 shared pathwaysSmall cell lung cancer, Cyclin D associated events in G1 Related via 2 shared pathways including Small cell lung cancer, Cyclin D associated events in G1. CDKN1B 3 shared pathwaysSmall cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21, Cyclin D associated events in G1 Related via 3 shared pathways including Small cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21. CCNE2 2 shared pathwaysSmall cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21 Related via 2 shared pathways including Small cell lung cancer, SCF(Skp2)-mediated degradation of p27/p21.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SKP2	0	[]	3	["Small cell lung cancer","SCF(Skp2)-mediated degradation of p27\/p21","Cyclin D associated events in G1"]	0	[]
PTK6	0	[]	2	["SCF(Skp2)-mediated degradation of p27\/p21","Cyclin D associated events in G1"]	0	[]
CDKN2B	0	[]	2	["Small cell lung cancer","Cyclin D associated events in G1"]	0	[]
CDKN1B	0	[]	3	["Small cell lung cancer","SCF(Skp2)-mediated degradation of p27\/p21","Cyclin D associated events in G1"]	0	[]
CCNE2	0	[]	2	["Small cell lung cancer","SCF(Skp2)-mediated degradation of p27\/p21"]	0	[]

Diseases Linked via Similar Genes

Hepatocellular carcinoma Linked via 3 of 5 related genesSKP2, CDKN2B, CDKN1B Breast cancer Linked via 2 of 5 related genesSKP2, CDKN2B Coronary artery disease Linked via 2 of 5 related genesSKP2, CDKN2B Ovarian neoplasms Linked via 2 of 5 related genesSKP2, CDKN1B Liver neoplasms Linked via 2 of 5 related genesCDKN2B, CDKN1B

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hepatocellular carcinoma	3	["SKP2","CDKN2B","CDKN1B"]
Breast cancer	2	["SKP2","CDKN2B"]
Coronary artery disease	2	["SKP2","CDKN2B"]
Ovarian neoplasms	2	["SKP2","CDKN1B"]
Liver neoplasms	2	["CDKN2B","CDKN1B"]