CASP6 (caspase 6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 839
• Gene name: Caspase 6
• Gene symbol: CASP6
• Synonyms (NCBI Gene): CSP-6, MCH2, caspase-6
• Chromosome: 4
• Chromosome location: 4q25
• Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic

miRNA Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT864083	hsa-miR-122	CLIP-seq
MIRT864084	hsa-miR-1224-3p	CLIP-seq
MIRT864085	hsa-miR-124	CLIP-seq
MIRT864086	hsa-miR-125a-3p	CLIP-seq
MIRT864087	hsa-miR-1297	CLIP-seq
MIRT864088	hsa-miR-130a	CLIP-seq
MIRT864089	hsa-miR-130b	CLIP-seq
MIRT864090	hsa-miR-1343	CLIP-seq
MIRT864091	hsa-miR-136	CLIP-seq
MIRT864092	hsa-miR-1976	CLIP-seq
MIRT864093	hsa-miR-2117	CLIP-seq
MIRT864094	hsa-miR-2682	CLIP-seq
MIRT864095	hsa-miR-26a	CLIP-seq
MIRT864096	hsa-miR-26b	CLIP-seq
MIRT864097	hsa-miR-301a	CLIP-seq
MIRT864098	hsa-miR-301b	CLIP-seq
MIRT864099	hsa-miR-3135b	CLIP-seq
MIRT864100	hsa-miR-3155	CLIP-seq
MIRT864101	hsa-miR-3155b	CLIP-seq
MIRT864102	hsa-miR-3195	CLIP-seq
MIRT864103	hsa-miR-3652	CLIP-seq
MIRT864104	hsa-miR-3663-5p	CLIP-seq
MIRT864105	hsa-miR-3666	CLIP-seq
MIRT864106	hsa-miR-3714	CLIP-seq
MIRT864107	hsa-miR-3910	CLIP-seq
MIRT864108	hsa-miR-3934	CLIP-seq
MIRT864109	hsa-miR-4277	CLIP-seq
MIRT864110	hsa-miR-4279	CLIP-seq
MIRT864111	hsa-miR-4295	CLIP-seq
MIRT864112	hsa-miR-4430	CLIP-seq
MIRT864113	hsa-miR-4454	CLIP-seq
MIRT864114	hsa-miR-4465	CLIP-seq
MIRT864115	hsa-miR-4477b	CLIP-seq
MIRT864116	hsa-miR-449c	CLIP-seq
MIRT864117	hsa-miR-4508	CLIP-seq
MIRT864118	hsa-miR-454	CLIP-seq
MIRT864119	hsa-miR-4716-5p	CLIP-seq
MIRT864120	hsa-miR-4722-3p	CLIP-seq
MIRT864121	hsa-miR-4781-3p	CLIP-seq
MIRT864122	hsa-miR-4787-3p	CLIP-seq
MIRT864123	hsa-miR-484	CLIP-seq
MIRT864124	hsa-miR-506	CLIP-seq
MIRT864125	hsa-miR-515-5p	CLIP-seq
MIRT864126	hsa-miR-562	CLIP-seq
MIRT864127	hsa-miR-652	CLIP-seq
MIRT864128	hsa-miR-764	CLIP-seq
MIRT864084	hsa-miR-1224-3p	CLIP-seq
MIRT864086	hsa-miR-125a-3p	CLIP-seq
MIRT864091	hsa-miR-136	CLIP-seq
MIRT864100	hsa-miR-3155	CLIP-seq
MIRT864101	hsa-miR-3155b	CLIP-seq
MIRT864104	hsa-miR-3663-5p	CLIP-seq
MIRT864108	hsa-miR-3934	CLIP-seq
MIRT864113	hsa-miR-4454	CLIP-seq
MIRT864119	hsa-miR-4716-5p	CLIP-seq
MIRT864121	hsa-miR-4781-3p	CLIP-seq
MIRT864123	hsa-miR-484	CLIP-seq
MIRT864125	hsa-miR-515-5p	CLIP-seq
MIRT864128	hsa-miR-764	CLIP-seq
MIRT864084	hsa-miR-1224-3p	CLIP-seq
MIRT864086	hsa-miR-125a-3p	CLIP-seq
MIRT1956151	hsa-miR-1307	CLIP-seq
MIRT1956152	hsa-miR-197	CLIP-seq
MIRT864092	hsa-miR-1976	CLIP-seq
MIRT1956153	hsa-miR-340	CLIP-seq
MIRT1956154	hsa-miR-3614-3p	CLIP-seq
MIRT864104	hsa-miR-3663-5p	CLIP-seq
MIRT1956155	hsa-miR-3691-3p	CLIP-seq
MIRT1956156	hsa-miR-3926	CLIP-seq
MIRT864108	hsa-miR-3934	CLIP-seq
MIRT864110	hsa-miR-4279	CLIP-seq
MIRT1956157	hsa-miR-4284	CLIP-seq
MIRT1956158	hsa-miR-4297	CLIP-seq
MIRT864113	hsa-miR-4454	CLIP-seq
MIRT1956159	hsa-miR-4638-5p	CLIP-seq
MIRT864120	hsa-miR-4722-3p	CLIP-seq
MIRT1956160	hsa-miR-5096	CLIP-seq
MIRT1956161	hsa-miR-513a-3p	CLIP-seq
MIRT1956162	hsa-miR-548s	CLIP-seq
MIRT864126	hsa-miR-562	CLIP-seq
MIRT864128	hsa-miR-764	CLIP-seq
MIRT864083	hsa-miR-122	CLIP-seq
MIRT864084	hsa-miR-1224-3p	CLIP-seq
MIRT864086	hsa-miR-125a-3p	CLIP-seq
MIRT2193812	hsa-miR-1305	CLIP-seq
MIRT1956151	hsa-miR-1307	CLIP-seq
MIRT864088	hsa-miR-130a	CLIP-seq
MIRT864089	hsa-miR-130b	CLIP-seq
MIRT2193813	hsa-miR-155	CLIP-seq
MIRT864097	hsa-miR-301a	CLIP-seq
MIRT864098	hsa-miR-301b	CLIP-seq
MIRT864099	hsa-miR-3135b	CLIP-seq
MIRT2193814	hsa-miR-3145-3p	CLIP-seq
MIRT2193815	hsa-miR-3620	CLIP-seq
MIRT864103	hsa-miR-3652	CLIP-seq
MIRT864105	hsa-miR-3666	CLIP-seq
MIRT2193816	hsa-miR-3684	CLIP-seq
MIRT864108	hsa-miR-3934	CLIP-seq
MIRT2193817	hsa-miR-3977	CLIP-seq
MIRT2193818	hsa-miR-410	CLIP-seq
MIRT2193819	hsa-miR-412	CLIP-seq
MIRT1956157	hsa-miR-4284	CLIP-seq
MIRT864111	hsa-miR-4295	CLIP-seq
MIRT864112	hsa-miR-4430	CLIP-seq
MIRT864113	hsa-miR-4454	CLIP-seq
MIRT864118	hsa-miR-454	CLIP-seq
MIRT1956159	hsa-miR-4638-5p	CLIP-seq
MIRT2193820	hsa-miR-4797-5p	CLIP-seq
MIRT864127	hsa-miR-652	CLIP-seq
MIRT2193821	hsa-miR-759	CLIP-seq
MIRT864128	hsa-miR-764	CLIP-seq
MIRT864087	hsa-miR-1297	CLIP-seq
MIRT864090	hsa-miR-1343	CLIP-seq
MIRT864092	hsa-miR-1976	CLIP-seq
MIRT864095	hsa-miR-26a	CLIP-seq
MIRT864096	hsa-miR-26b	CLIP-seq
MIRT1956154	hsa-miR-3614-3p	CLIP-seq
MIRT864110	hsa-miR-4279	CLIP-seq
MIRT1956158	hsa-miR-4297	CLIP-seq
MIRT864114	hsa-miR-4465	CLIP-seq
MIRT864120	hsa-miR-4722-3p	CLIP-seq
MIRT864087	hsa-miR-1297	CLIP-seq
MIRT864090	hsa-miR-1343	CLIP-seq
MIRT864092	hsa-miR-1976	CLIP-seq
MIRT864095	hsa-miR-26a	CLIP-seq
MIRT864096	hsa-miR-26b	CLIP-seq
MIRT1956154	hsa-miR-3614-3p	CLIP-seq
MIRT864110	hsa-miR-4279	CLIP-seq
MIRT1956158	hsa-miR-4297	CLIP-seq
MIRT864114	hsa-miR-4465	CLIP-seq
MIRT864120	hsa-miR-4722-3p	CLIP-seq
MIRT864087	hsa-miR-1297	CLIP-seq
MIRT864090	hsa-miR-1343	CLIP-seq
MIRT864092	hsa-miR-1976	CLIP-seq
MIRT864095	hsa-miR-26a	CLIP-seq
MIRT864096	hsa-miR-26b	CLIP-seq
MIRT1956154	hsa-miR-3614-3p	CLIP-seq
MIRT864110	hsa-miR-4279	CLIP-seq
MIRT1956158	hsa-miR-4297	CLIP-seq
MIRT864114	hsa-miR-4465	CLIP-seq
MIRT864120	hsa-miR-4722-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002218	Process	Activation of innate immune response	IDA	32298652
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	19133298, 22858542, 24904167, 27032039, 27911442, 32029622
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	22253444
GO:0004197	Function	Cysteine-type endopeptidase activity	ISS
GO:0005515	Function	Protein binding	IPI	12888622, 18408014, 18723680, 25241761, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	27911442
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27911442
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	17167422
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IDA	12888622
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	7796396
GO:0006915	Process	Apoptotic process	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	7796396
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	TAS	7796396
GO:0016540	Process	Protein autoprocessing	IDA	19133298
GO:0016787	Function	Hydrolase activity	IEA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0042802	Function	Identical protein binding	IPI	20890311, 21988832, 25416956, 31515488, 32296183
GO:0043065	Process	Positive regulation of apoptotic process	IDA	32298652
GO:0043067	Process	Regulation of programmed cell death	IDA	27911442
GO:0043525	Process	Positive regulation of neuron apoptotic process	IBA
GO:0051604	Process	Protein maturation	IEA
GO:0060545	Process	Positive regulation of necroptotic process	IDA	32298652
GO:0070269	Process	Pyroptotic inflammatory response	IDA	32298652
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IDA	22858542
GO:0072734	Process	Cellular response to staurosporine	IEA
GO:0072734	Process	Cellular response to staurosporine	IMP	22253444
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	32029622
GO:0097284	Process	Hepatocyte apoptotic process	IDA	32029622

Other IDs

• MIM: 601532
• HGNC: 1507
• e!Ensembl: ENSG00000138794

Protein

• UniProt ID: P55212
• Protein name: Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
• Protein function: Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:19133298, PubMed:22858542, PubMed:27032039, PubMed:28864531, PubMed:30420425, PubMed:32298652, PubMed:8663580). A
• PDB: 2WDP , 3K7E , 3NKF , 3NR2 , 3OD5 , 3P45 , 3P4U , 3QNW , 3S70 , 3S8E , 3V6L , 3V6M , 4EJF , 4FXO , 4HVA , 4IYR , 4N5D , 4N6G , 4N7J , 4N7M , 4NBK , 4NBL , 4NBN , 6DEU , 6DEV , 8EG5 , 8EG6 , 8F78 , 8F96 , 8F97 , 8F98 , 8F99 , 8F9A , 8F9B , 8F9C , 8F9D , 8FBV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00656	Peptidase_C14	45 → 288		Domain

• Sequence:

  MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
  LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
  HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
  QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
  SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN

• Sequence length: 293

Pathways

KEGG Pathway	Reactome Pathway
Apoptosis	Apoptotic cleavage of cellular proteins
Lipid and atherosclerosis	Caspase-mediated cleavage of cytoskeletal proteins
	Breakdown of the nuclear lamina
	TP53 Regulates Transcription of Caspase Activators and Caspases

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PIDD1 2 shared pathwaysApoptosis, TP53 Regulates Transcription of Caspase Activators and Caspases Related via 2 shared pathways including Apoptosis, TP53 Regulates Transcription of Caspase Activators and Caspases. CASP2 2 shared pathwaysApoptosis, TP53 Regulates Transcription of Caspase Activators and Caspases Related via 2 shared pathways including Apoptosis, TP53 Regulates Transcription of Caspase Activators and Caspases. CASP7 4 shared pathwaysApoptosis, Lipid and atherosclerosis, Apoptotic cleavage of cellular proteins, Caspase-mediated cleavage of cytoskeletal proteins Related via 4 shared pathways including Apoptosis, Lipid and atherosclerosis. SPTAN1 2 shared pathwaysApoptosis, Caspase-mediated cleavage of cytoskeletal proteins Related via 2 shared pathways including Apoptosis, Caspase-mediated cleavage of cytoskeletal proteins. ERN1 2 shared pathwaysApoptosis, Lipid and atherosclerosis Related via 2 shared pathways including Apoptosis, Lipid and atherosclerosis.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PIDD1	0	[]	2	["Apoptosis","TP53 Regulates Transcription of Caspase Activators and Caspases"]	0	[]
CASP2	0	[]	2	["Apoptosis","TP53 Regulates Transcription of Caspase Activators and Caspases"]	0	[]
CASP7	0	[]	4	["Apoptosis","Lipid and atherosclerosis","Apoptotic cleavage of cellular proteins","Caspase-mediated cleavage of cytoskeletal proteins"]	0	[]
SPTAN1	0	[]	2	["Apoptosis","Caspase-mediated cleavage of cytoskeletal proteins"]	0	[]
ERN1	0	[]	2	["Apoptosis","Lipid and atherosclerosis"]	0	[]

Diseases Linked via Similar Genes

Intellectual developmental disorder Linked via 3 of 5 related genesPIDD1, CASP2, SPTAN1 Breast cancer Linked via 2 of 5 related genesPIDD1, CASP7 Renal cell carcinoma Linked via 2 of 5 related genesPIDD1, CASP2 Alzheimer disease Linked via 2 of 5 related genesCASP7, ERN1 Aortic stenosis Linked via 1 of 5 related genesPIDD1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Intellectual developmental disorder	3	["PIDD1","CASP2","SPTAN1"]
Breast cancer	2	["PIDD1","CASP7"]
Renal cell carcinoma	2	["PIDD1","CASP2"]
Alzheimer disease	2	["CASP7","ERN1"]
Aortic stenosis	1	["PIDD1"]