CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4)

Gene

• Entrez ID: 27092
• Gene name: Calcium voltage-gated channel auxiliary subunit gamma 4
• Gene symbol: CACNG4
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q24.2
• Summary: The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017598	hsa-miR-335-5p	Microarray	18185580
MIRT858086	hsa-miR-1	CLIP-seq
MIRT858087	hsa-miR-105	CLIP-seq
MIRT858088	hsa-miR-1243	CLIP-seq
MIRT858089	hsa-miR-1270	CLIP-seq
MIRT858090	hsa-miR-1273f	CLIP-seq
MIRT858091	hsa-miR-1286	CLIP-seq
MIRT858092	hsa-miR-1289	CLIP-seq
MIRT858093	hsa-miR-1291	CLIP-seq
MIRT858094	hsa-miR-1321	CLIP-seq
MIRT858095	hsa-miR-149	CLIP-seq
MIRT858096	hsa-miR-1587	CLIP-seq
MIRT858097	hsa-miR-1827	CLIP-seq
MIRT858098	hsa-miR-185	CLIP-seq
MIRT858099	hsa-miR-1915	CLIP-seq
MIRT858100	hsa-miR-206	CLIP-seq
MIRT858101	hsa-miR-208a	CLIP-seq
MIRT858102	hsa-miR-208b	CLIP-seq
MIRT858103	hsa-miR-2277-3p	CLIP-seq
MIRT858104	hsa-miR-2355-5p	CLIP-seq
MIRT858105	hsa-miR-24	CLIP-seq
MIRT858106	hsa-miR-29a	CLIP-seq
MIRT858107	hsa-miR-29b	CLIP-seq
MIRT858108	hsa-miR-29c	CLIP-seq
MIRT858109	hsa-miR-300	CLIP-seq
MIRT858110	hsa-miR-3064-5p	CLIP-seq
MIRT858111	hsa-miR-3125	CLIP-seq
MIRT858112	hsa-miR-3151	CLIP-seq
MIRT858113	hsa-miR-3165	CLIP-seq
MIRT858114	hsa-miR-3180	CLIP-seq
MIRT858115	hsa-miR-3180-3p	CLIP-seq
MIRT858116	hsa-miR-3196	CLIP-seq
MIRT858117	hsa-miR-3198	CLIP-seq
MIRT858118	hsa-miR-3202	CLIP-seq
MIRT858119	hsa-miR-320e	CLIP-seq
MIRT858120	hsa-miR-330-3p	CLIP-seq
MIRT858121	hsa-miR-3612	CLIP-seq
MIRT858122	hsa-miR-3613-3p	CLIP-seq
MIRT858123	hsa-miR-3617	CLIP-seq
MIRT858124	hsa-miR-3621	CLIP-seq
MIRT858125	hsa-miR-3646	CLIP-seq
MIRT858126	hsa-miR-3654	CLIP-seq
MIRT858127	hsa-miR-3673	CLIP-seq
MIRT858128	hsa-miR-3689d	CLIP-seq
MIRT858129	hsa-miR-371-5p	CLIP-seq
MIRT858130	hsa-miR-371b-5p	CLIP-seq
MIRT858131	hsa-miR-381	CLIP-seq
MIRT858132	hsa-miR-382	CLIP-seq
MIRT858133	hsa-miR-3914	CLIP-seq
MIRT858134	hsa-miR-3916	CLIP-seq
MIRT858135	hsa-miR-3926	CLIP-seq
MIRT858136	hsa-miR-3928	CLIP-seq
MIRT858137	hsa-miR-4265	CLIP-seq
MIRT858138	hsa-miR-4270	CLIP-seq
MIRT858139	hsa-miR-4284	CLIP-seq
MIRT858140	hsa-miR-4294	CLIP-seq
MIRT858141	hsa-miR-4296	CLIP-seq
MIRT858142	hsa-miR-4306	CLIP-seq
MIRT858143	hsa-miR-4307	CLIP-seq
MIRT858144	hsa-miR-4309	CLIP-seq
MIRT858145	hsa-miR-4314	CLIP-seq
MIRT858146	hsa-miR-432	CLIP-seq
MIRT858147	hsa-miR-4322	CLIP-seq
MIRT858148	hsa-miR-4419a	CLIP-seq
MIRT858149	hsa-miR-4433	CLIP-seq
MIRT858150	hsa-miR-4441	CLIP-seq
MIRT858151	hsa-miR-4443	CLIP-seq
MIRT858152	hsa-miR-4446-3p	CLIP-seq
MIRT858153	hsa-miR-4447	CLIP-seq
MIRT858154	hsa-miR-4468	CLIP-seq
MIRT858155	hsa-miR-4472	CLIP-seq
MIRT858156	hsa-miR-4476	CLIP-seq
MIRT858157	hsa-miR-4488	CLIP-seq
MIRT858158	hsa-miR-4492	CLIP-seq
MIRT858159	hsa-miR-4498	CLIP-seq
MIRT858160	hsa-miR-4510	CLIP-seq
MIRT858161	hsa-miR-4531	CLIP-seq
MIRT858162	hsa-miR-4534	CLIP-seq
MIRT858163	hsa-miR-4640-5p	CLIP-seq
MIRT858164	hsa-miR-4644	CLIP-seq
MIRT858165	hsa-miR-4649-3p	CLIP-seq
MIRT858166	hsa-miR-4656	CLIP-seq
MIRT858167	hsa-miR-4666-3p	CLIP-seq
MIRT858168	hsa-miR-4667-5p	CLIP-seq
MIRT858169	hsa-miR-4670-3p	CLIP-seq
MIRT858170	hsa-miR-4675	CLIP-seq
MIRT858171	hsa-miR-4677-3p	CLIP-seq
MIRT858172	hsa-miR-4685-5p	CLIP-seq
MIRT858173	hsa-miR-4697-5p	CLIP-seq
MIRT858174	hsa-miR-4700-5p	CLIP-seq
MIRT858175	hsa-miR-4715-5p	CLIP-seq
MIRT858176	hsa-miR-4720-3p	CLIP-seq
MIRT858177	hsa-miR-4721	CLIP-seq
MIRT858178	hsa-miR-4722-5p	CLIP-seq
MIRT858179	hsa-miR-4726-3p	CLIP-seq
MIRT858180	hsa-miR-4726-5p	CLIP-seq
MIRT858181	hsa-miR-4728-5p	CLIP-seq
MIRT858182	hsa-miR-4730	CLIP-seq
MIRT858183	hsa-miR-4739	CLIP-seq
MIRT858184	hsa-miR-4741	CLIP-seq
MIRT858185	hsa-miR-4753-5p	CLIP-seq
MIRT858186	hsa-miR-4756-5p	CLIP-seq
MIRT858187	hsa-miR-4779	CLIP-seq
MIRT858188	hsa-miR-4789-5p	CLIP-seq
MIRT858189	hsa-miR-4794	CLIP-seq
MIRT858190	hsa-miR-4804-3p	CLIP-seq
MIRT858191	hsa-miR-486-3p	CLIP-seq
MIRT858192	hsa-miR-491-5p	CLIP-seq
MIRT858193	hsa-miR-493	CLIP-seq
MIRT858194	hsa-miR-499-5p	CLIP-seq
MIRT858195	hsa-miR-513a-5p	CLIP-seq
MIRT858196	hsa-miR-516b	CLIP-seq
MIRT858197	hsa-miR-548ag	CLIP-seq
MIRT858198	hsa-miR-548ai	CLIP-seq
MIRT858199	hsa-miR-552	CLIP-seq
MIRT858200	hsa-miR-582-3p	CLIP-seq
MIRT858201	hsa-miR-583	CLIP-seq
MIRT858202	hsa-miR-604	CLIP-seq
MIRT858203	hsa-miR-613	CLIP-seq
MIRT858204	hsa-miR-620	CLIP-seq
MIRT858205	hsa-miR-637	CLIP-seq
MIRT858206	hsa-miR-641	CLIP-seq
MIRT858207	hsa-miR-646	CLIP-seq
MIRT858208	hsa-miR-647	CLIP-seq
MIRT858209	hsa-miR-650	CLIP-seq
MIRT858210	hsa-miR-762	CLIP-seq
MIRT858211	hsa-miR-764	CLIP-seq
MIRT858212	hsa-miR-765	CLIP-seq
MIRT858213	hsa-miR-873	CLIP-seq
MIRT858214	hsa-miR-876-3p	CLIP-seq
MIRT858215	hsa-miR-885-3p	CLIP-seq
MIRT858216	hsa-miR-924	CLIP-seq
MIRT1954838	hsa-miR-1262	CLIP-seq
MIRT858090	hsa-miR-1273f	CLIP-seq
MIRT858094	hsa-miR-1321	CLIP-seq
MIRT1954839	hsa-miR-143	CLIP-seq
MIRT858095	hsa-miR-149	CLIP-seq
MIRT858098	hsa-miR-185	CLIP-seq
MIRT1954840	hsa-miR-1972	CLIP-seq
MIRT858105	hsa-miR-24	CLIP-seq
MIRT858110	hsa-miR-3064-5p	CLIP-seq
MIRT858111	hsa-miR-3125	CLIP-seq
MIRT1954841	hsa-miR-3175	CLIP-seq
MIRT1954842	hsa-miR-3176	CLIP-seq
MIRT858114	hsa-miR-3180	CLIP-seq
MIRT858115	hsa-miR-3180-3p	CLIP-seq
MIRT858116	hsa-miR-3196	CLIP-seq
MIRT858118	hsa-miR-3202	CLIP-seq
MIRT1954843	hsa-miR-323-5p	CLIP-seq
MIRT1954844	hsa-miR-34a	CLIP-seq
MIRT1954845	hsa-miR-34c-5p	CLIP-seq
MIRT858124	hsa-miR-3621	CLIP-seq
MIRT1954846	hsa-miR-3658	CLIP-seq
MIRT858128	hsa-miR-3689d	CLIP-seq
MIRT858134	hsa-miR-3916	CLIP-seq
MIRT1954847	hsa-miR-3920	CLIP-seq
MIRT1954848	hsa-miR-3922-3p	CLIP-seq
MIRT858136	hsa-miR-3928	CLIP-seq
MIRT1954849	hsa-miR-4251	CLIP-seq
MIRT858139	hsa-miR-4284	CLIP-seq
MIRT858142	hsa-miR-4306	CLIP-seq
MIRT858145	hsa-miR-4314	CLIP-seq
MIRT1954850	hsa-miR-4329	CLIP-seq
MIRT858148	hsa-miR-4419a	CLIP-seq
MIRT858152	hsa-miR-4446-3p	CLIP-seq
MIRT858153	hsa-miR-4447	CLIP-seq
MIRT1954851	hsa-miR-4455	CLIP-seq
MIRT858155	hsa-miR-4472	CLIP-seq
MIRT858156	hsa-miR-4476	CLIP-seq
MIRT858157	hsa-miR-4488	CLIP-seq
MIRT858158	hsa-miR-4492	CLIP-seq
MIRT858159	hsa-miR-4498	CLIP-seq
MIRT1954852	hsa-miR-449a	CLIP-seq
MIRT1954853	hsa-miR-449b	CLIP-seq
MIRT858160	hsa-miR-4510	CLIP-seq
MIRT1954854	hsa-miR-4527	CLIP-seq
MIRT858162	hsa-miR-4534	CLIP-seq
MIRT858163	hsa-miR-4640-5p	CLIP-seq
MIRT858164	hsa-miR-4644	CLIP-seq
MIRT1954855	hsa-miR-4649-5p	CLIP-seq
MIRT1954856	hsa-miR-4651	CLIP-seq
MIRT858168	hsa-miR-4667-5p	CLIP-seq
MIRT858173	hsa-miR-4697-5p	CLIP-seq
MIRT858174	hsa-miR-4700-5p	CLIP-seq
MIRT1954857	hsa-miR-4701-3p	CLIP-seq
MIRT1954858	hsa-miR-4708-5p	CLIP-seq
MIRT1954859	hsa-miR-4716-5p	CLIP-seq
MIRT1954860	hsa-miR-4717-5p	CLIP-seq
MIRT858180	hsa-miR-4726-5p	CLIP-seq
MIRT858181	hsa-miR-4728-5p	CLIP-seq
MIRT858182	hsa-miR-4730	CLIP-seq
MIRT858183	hsa-miR-4739	CLIP-seq
MIRT858186	hsa-miR-4756-5p	CLIP-seq
MIRT1954861	hsa-miR-4770	CLIP-seq
MIRT1954862	hsa-miR-4773	CLIP-seq
MIRT858189	hsa-miR-4794	CLIP-seq
MIRT858191	hsa-miR-486-3p	CLIP-seq
MIRT1954863	hsa-miR-541	CLIP-seq
MIRT1954864	hsa-miR-542-3p	CLIP-seq
MIRT858201	hsa-miR-583	CLIP-seq
MIRT1954865	hsa-miR-608	CLIP-seq
MIRT1954866	hsa-miR-609	CLIP-seq
MIRT858205	hsa-miR-637	CLIP-seq
MIRT1954867	hsa-miR-654-5p	CLIP-seq
MIRT858210	hsa-miR-762	CLIP-seq
MIRT858215	hsa-miR-885-3p	CLIP-seq
MIRT858086	hsa-miR-1	CLIP-seq
MIRT2192371	hsa-miR-106a	CLIP-seq
MIRT2192372	hsa-miR-106b	CLIP-seq
MIRT2192373	hsa-miR-1185	CLIP-seq
MIRT2192374	hsa-miR-1207-3p	CLIP-seq
MIRT2192375	hsa-miR-1253	CLIP-seq
MIRT858089	hsa-miR-1270	CLIP-seq
MIRT858090	hsa-miR-1273f	CLIP-seq
MIRT858094	hsa-miR-1321	CLIP-seq
MIRT2192376	hsa-miR-136	CLIP-seq
MIRT858095	hsa-miR-149	CLIP-seq
MIRT2192377	hsa-miR-1538	CLIP-seq
MIRT2192378	hsa-miR-17	CLIP-seq
MIRT858098	hsa-miR-185	CLIP-seq
MIRT858099	hsa-miR-1915	CLIP-seq
MIRT2192379	hsa-miR-193a-5p	CLIP-seq
MIRT2192380	hsa-miR-204	CLIP-seq
MIRT858100	hsa-miR-206	CLIP-seq
MIRT858101	hsa-miR-208a	CLIP-seq
MIRT858102	hsa-miR-208b	CLIP-seq
MIRT2192381	hsa-miR-20a	CLIP-seq
MIRT2192382	hsa-miR-20b	CLIP-seq
MIRT2192383	hsa-miR-211	CLIP-seq
MIRT858105	hsa-miR-24	CLIP-seq
MIRT2192384	hsa-miR-302a	CLIP-seq
MIRT2192385	hsa-miR-302b	CLIP-seq
MIRT2192386	hsa-miR-302c	CLIP-seq
MIRT2192387	hsa-miR-302d	CLIP-seq
MIRT2192388	hsa-miR-302e	CLIP-seq
MIRT858110	hsa-miR-3064-5p	CLIP-seq
MIRT858111	hsa-miR-3125	CLIP-seq
MIRT2192389	hsa-miR-3155	CLIP-seq
MIRT2192390	hsa-miR-3155b	CLIP-seq
MIRT2192391	hsa-miR-3160-5p	CLIP-seq
MIRT1954841	hsa-miR-3175	CLIP-seq
MIRT2192392	hsa-miR-335	CLIP-seq
MIRT2192393	hsa-miR-34c-3p	CLIP-seq
MIRT2192394	hsa-miR-3614-3p	CLIP-seq
MIRT2192395	hsa-miR-3648	CLIP-seq
MIRT1954846	hsa-miR-3658	CLIP-seq
MIRT2192396	hsa-miR-3661	CLIP-seq
MIRT858127	hsa-miR-3673	CLIP-seq
MIRT2192397	hsa-miR-3679-5p	CLIP-seq
MIRT2192398	hsa-miR-3687	CLIP-seq
MIRT858128	hsa-miR-3689d	CLIP-seq
MIRT2192399	hsa-miR-372	CLIP-seq
MIRT2192400	hsa-miR-373	CLIP-seq
MIRT2192401	hsa-miR-3913-3p	CLIP-seq
MIRT858133	hsa-miR-3914	CLIP-seq
MIRT858134	hsa-miR-3916	CLIP-seq
MIRT1954847	hsa-miR-3920	CLIP-seq
MIRT2192402	hsa-miR-3929	CLIP-seq
MIRT1954849	hsa-miR-4251	CLIP-seq
MIRT2192403	hsa-miR-4252	CLIP-seq
MIRT858139	hsa-miR-4284	CLIP-seq
MIRT858142	hsa-miR-4306	CLIP-seq
MIRT858145	hsa-miR-4314	CLIP-seq
MIRT858148	hsa-miR-4419a	CLIP-seq
MIRT2192404	hsa-miR-4419b	CLIP-seq
MIRT2192405	hsa-miR-4434	CLIP-seq
MIRT2192406	hsa-miR-4442	CLIP-seq
MIRT2192407	hsa-miR-4478	CLIP-seq
MIRT2192408	hsa-miR-4493	CLIP-seq
MIRT858160	hsa-miR-4510	CLIP-seq
MIRT2192409	hsa-miR-4514	CLIP-seq
MIRT2192410	hsa-miR-4516	CLIP-seq
MIRT858161	hsa-miR-4531	CLIP-seq
MIRT858162	hsa-miR-4534	CLIP-seq
MIRT2192411	hsa-miR-4539	CLIP-seq
MIRT858163	hsa-miR-4640-5p	CLIP-seq
MIRT858164	hsa-miR-4644	CLIP-seq
MIRT2192412	hsa-miR-4645-5p	CLIP-seq
MIRT2192413	hsa-miR-4659a-3p	CLIP-seq
MIRT2192414	hsa-miR-4659b-3p	CLIP-seq
MIRT858168	hsa-miR-4667-5p	CLIP-seq
MIRT2192415	hsa-miR-4673	CLIP-seq
MIRT2192416	hsa-miR-4692	CLIP-seq
MIRT858174	hsa-miR-4700-5p	CLIP-seq
MIRT2192417	hsa-miR-4706	CLIP-seq
MIRT2192418	hsa-miR-4707-5p	CLIP-seq
MIRT2192419	hsa-miR-4714-5p	CLIP-seq
MIRT2192420	hsa-miR-4717-3p	CLIP-seq
MIRT858176	hsa-miR-4720-3p	CLIP-seq
MIRT858180	hsa-miR-4726-5p	CLIP-seq
MIRT858181	hsa-miR-4728-5p	CLIP-seq
MIRT858183	hsa-miR-4739	CLIP-seq
MIRT2192421	hsa-miR-4745-3p	CLIP-seq
MIRT2192422	hsa-miR-4749-5p	CLIP-seq
MIRT858186	hsa-miR-4756-5p	CLIP-seq
MIRT2192423	hsa-miR-4778-3p	CLIP-seq
MIRT858189	hsa-miR-4794	CLIP-seq
MIRT858190	hsa-miR-4804-3p	CLIP-seq
MIRT2192424	hsa-miR-484	CLIP-seq
MIRT858191	hsa-miR-486-3p	CLIP-seq
MIRT2192425	hsa-miR-489	CLIP-seq
MIRT2192426	hsa-miR-492	CLIP-seq
MIRT858194	hsa-miR-499-5p	CLIP-seq
MIRT2192427	hsa-miR-512-3p	CLIP-seq
MIRT858195	hsa-miR-513a-5p	CLIP-seq
MIRT2192428	hsa-miR-515-5p	CLIP-seq
MIRT858196	hsa-miR-516b	CLIP-seq
MIRT2192429	hsa-miR-519d	CLIP-seq
MIRT2192430	hsa-miR-520a-3p	CLIP-seq
MIRT2192431	hsa-miR-520b	CLIP-seq
MIRT2192432	hsa-miR-520c-3p	CLIP-seq
MIRT2192433	hsa-miR-520d-3p	CLIP-seq
MIRT2192434	hsa-miR-520e	CLIP-seq
MIRT2192435	hsa-miR-520g	CLIP-seq
MIRT2192436	hsa-miR-520h	CLIP-seq
MIRT1954864	hsa-miR-542-3p	CLIP-seq
MIRT858199	hsa-miR-552	CLIP-seq
MIRT2192437	hsa-miR-578	CLIP-seq
MIRT858200	hsa-miR-582-3p	CLIP-seq
MIRT858201	hsa-miR-583	CLIP-seq
MIRT858203	hsa-miR-613	CLIP-seq
MIRT858204	hsa-miR-620	CLIP-seq
MIRT2192438	hsa-miR-631	CLIP-seq
MIRT858205	hsa-miR-637	CLIP-seq
MIRT858207	hsa-miR-646	CLIP-seq
MIRT858211	hsa-miR-764	CLIP-seq
MIRT858213	hsa-miR-873	CLIP-seq
MIRT858215	hsa-miR-885-3p	CLIP-seq
MIRT2192439	hsa-miR-93	CLIP-seq
MIRT858097	hsa-miR-1827	CLIP-seq
MIRT2385469	hsa-miR-4316	CLIP-seq
MIRT2385470	hsa-miR-4682	CLIP-seq
MIRT2385471	hsa-miR-4765	CLIP-seq
MIRT858205	hsa-miR-637	CLIP-seq
MIRT858089	hsa-miR-1270	CLIP-seq
MIRT858098	hsa-miR-185	CLIP-seq
MIRT2192403	hsa-miR-4252	CLIP-seq
MIRT858142	hsa-miR-4306	CLIP-seq
MIRT858146	hsa-miR-432	CLIP-seq
MIRT858161	hsa-miR-4531	CLIP-seq
MIRT858164	hsa-miR-4644	CLIP-seq
MIRT1954860	hsa-miR-4717-5p	CLIP-seq
MIRT858204	hsa-miR-620	CLIP-seq
MIRT858216	hsa-miR-924	CLIP-seq
MIRT858089	hsa-miR-1270	CLIP-seq
MIRT858098	hsa-miR-185	CLIP-seq
MIRT2192403	hsa-miR-4252	CLIP-seq
MIRT858142	hsa-miR-4306	CLIP-seq
MIRT858146	hsa-miR-432	CLIP-seq
MIRT858161	hsa-miR-4531	CLIP-seq
MIRT858164	hsa-miR-4644	CLIP-seq
MIRT1954860	hsa-miR-4717-5p	CLIP-seq
MIRT858204	hsa-miR-620	CLIP-seq
MIRT858216	hsa-miR-924	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IBA
GO:0005245	Function	Voltage-gated calcium channel activity	IEA
GO:0005246	Function	Calcium channel regulator activity	IDA	21127204
GO:0005262	Function	Calcium channel activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10613843
GO:0005891	Component	Voltage-gated calcium channel complex	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016247	Function	Channel regulator activity	IBA
GO:0019226	Process	Transmission of nerve impulse	IBA
GO:0019226	Process	Transmission of nerve impulse	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0032281	Component	AMPA glutamate receptor complex	IBA
GO:0032281	Component	AMPA glutamate receptor complex	IEA
GO:0032281	Component	AMPA glutamate receptor complex	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0035255	Function	Ionotropic glutamate receptor binding	IEA
GO:0036477	Component	Somatodendritic compartment	IEA
GO:0042220	Process	Response to cocaine	IEA
GO:0044297	Component	Cell body	IEA
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	IBA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098970	Process	Postsynaptic neurotransmitter receptor diffusion trapping	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1990454	Component	L-type voltage-gated calcium channel complex	IDA	21127204
GO:2000311	Process	Regulation of AMPA receptor activity	IDA	21172611

Other IDs

• MIM: 606404
• HGNC: 1408
• e!Ensembl: ENSG00000075461

Protein

• UniProt ID: Q9UBN1
• Protein name: Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4)
• Protein function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00822	PMP22_Claudin	6 → 202	PMP-22/EMP/MP20/Claudin family	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart left ventricle. {ECO:0000269|PubMed:21127204}.
• Sequence:

  MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGD
  LTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLL
  GGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYN
  YGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPYARMPSYRYRR
  RRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAASYSPDQEASF
  LQVHDFFQQDLKEGFHVSMLNRRTTPV

• Sequence length: 327

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SAPHO SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	37747033, 38291367	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	27602771	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	GWASCAT_DG	29594489		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	27102562		★★☆☆☆ Found in Text Mining + Unknown/Other Associations