Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	27202
Gene name	Complement C5a receptor 2
Gene symbol	C5AR2
Synonyms (NCBI Gene)	C5L2GPF77GPR77
Chromosome	19
Chromosome location	19q13.32
Summary	This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may inst

94 Show/Hide all (94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT689318	hsa-miR-5692a	HITS-CLIP	23313552
MIRT689317	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT689316	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT689315	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT689314	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT689313	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT689312	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT689311	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT689310	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689309	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689308	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT689307	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT689306	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT689305	hsa-miR-4486	HITS-CLIP	23313552
MIRT689304	hsa-miR-5186	HITS-CLIP	23313552
MIRT689303	hsa-miR-4537	HITS-CLIP	23313552
MIRT689302	hsa-miR-4252	HITS-CLIP	23313552
MIRT689301	hsa-miR-661	HITS-CLIP	23313552
MIRT689300	hsa-miR-1273a	HITS-CLIP	23313552
MIRT689299	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT689298	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT689297	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT689296	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689295	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689294	hsa-miR-7703	HITS-CLIP	23313552
MIRT689293	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT689292	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT689291	hsa-miR-510-5p	HITS-CLIP	23313552
MIRT689290	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT689289	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT689288	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT689287	hsa-miR-940	HITS-CLIP	23313552
MIRT689286	hsa-miR-3929	HITS-CLIP	23313552
MIRT689285	hsa-miR-4419b	HITS-CLIP	23313552
MIRT689284	hsa-miR-4478	HITS-CLIP	23313552
MIRT689283	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689282	hsa-miR-4459	HITS-CLIP	23313552
MIRT689281	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689280	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT689279	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689278	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT689277	hsa-miR-1827	HITS-CLIP	23313552
MIRT689276	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT689275	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT689274	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689273	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689272	hsa-miR-665	HITS-CLIP	23313552
MIRT689318	hsa-miR-5692a	HITS-CLIP	23313552
MIRT689317	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT689316	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT689315	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT689314	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT689313	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT689312	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT689311	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT689310	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689309	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689308	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT689307	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT689306	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT689305	hsa-miR-4486	HITS-CLIP	23313552
MIRT689304	hsa-miR-5186	HITS-CLIP	23313552
MIRT689303	hsa-miR-4537	HITS-CLIP	23313552
MIRT689302	hsa-miR-4252	HITS-CLIP	23313552
MIRT689301	hsa-miR-661	HITS-CLIP	23313552
MIRT689300	hsa-miR-1273a	HITS-CLIP	23313552
MIRT689299	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT689298	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT689297	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT689296	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689295	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689294	hsa-miR-7703	HITS-CLIP	23313552
MIRT689293	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT689292	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT689291	hsa-miR-510-5p	HITS-CLIP	23313552
MIRT689290	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT689289	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT689288	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT689287	hsa-miR-940	HITS-CLIP	23313552
MIRT689286	hsa-miR-3929	HITS-CLIP	23313552
MIRT689285	hsa-miR-4419b	HITS-CLIP	23313552
MIRT689284	hsa-miR-4478	HITS-CLIP	23313552
MIRT689283	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689282	hsa-miR-4459	HITS-CLIP	23313552
MIRT689281	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689280	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT689279	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689278	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT689277	hsa-miR-1827	HITS-CLIP	23313552
MIRT689276	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT689275	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT689274	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689273	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689272	hsa-miR-665	HITS-CLIP	23313552

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002430	Process	Complement receptor mediated signaling pathway	IBA
GO:0002682	Process	Regulation of immune system process	IEA
GO:0004875	Function	Complement receptor activity	IEA
GO:0004878	Function	Complement component C5a receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	12540846, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0009925	Component	Basal plasma membrane	IDA	22960554
GO:0016020	Component	Membrane	IEA
GO:0032677	Process	Regulation of interleukin-8 production	IMP	22496247
GO:0032715	Process	Negative regulation of interleukin-6 production	IMP	16204243
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IMP	16204243
GO:0038178	Process	Complement component C5a signaling pathway	IEA
GO:0045177	Component	Apical part of cell	IDA	22496247
GO:0090024	Process	Negative regulation of neutrophil chemotaxis	IMP	16204243

MIM	HGNC	e!Ensembl
609949	4527	ENSG00000134830

Q9P296

Protein name

C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77)

Protein function

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	52 → 233	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Frontal cortex, hippocampus, hypothalamus, pons and liver. {ECO:0000269|PubMed:11090875, ECO:0000269|PubMed:11165367}.

Sequence

MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVA
GKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYA
SVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHF
PARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVV
GFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Sequence length

337

Interactions

View interactions

Reactome Pathway
Peptide ligand-binding receptors
Regulation of Complement cascade

C5AR2 (complement C5a receptor 2)

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