BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 114049
• Gene name: BUD23 rRNA methyltransferase and ribosome maturation factor
• Gene symbol: BUD23
• Synonyms (NCBI Gene): HASJ4442, HUSSY-3, MERM1, PP3381, WBMT, WBSCR22
• Chromosome: 7
• Chromosome location: 7q11.23
• Summary: This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a m

miRNA Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT611882	hsa-miR-4308	HITS-CLIP	19536157
MIRT611881	hsa-miR-4292	HITS-CLIP	19536157
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT611875	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT611882	hsa-miR-4308	HITS-CLIP	19536157
MIRT611881	hsa-miR-4292	HITS-CLIP	19536157
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT615974	hsa-miR-875-3p	HITS-CLIP	19536157
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT611875	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT641480	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615973	hsa-miR-3978	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT641480	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT641480	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615973	hsa-miR-3978	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615973	hsa-miR-3978	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615973	hsa-miR-3978	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT615974	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615973	hsa-miR-3978	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT611884	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT611883	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT611882	hsa-miR-4308	HITS-CLIP	23824327
MIRT611881	hsa-miR-4292	HITS-CLIP	23824327
MIRT611880	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT611879	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT611878	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611877	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611876	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611875	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT611874	hsa-miR-1238-3p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	25851604, 28514442, 32296183, 33961781, 34948388
GO:0005634	Component	Nucleus	IDA	34948388
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	25851604
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008168	Function	Methyltransferase activity	NAS	11124703
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0016435	Function	RRNA (guanine) methyltransferase activity	IBA
GO:0016435	Function	RRNA (guanine) methyltransferase activity	IEA
GO:0016435	Function	RRNA (guanine) methyltransferase activity	IMP	25851604
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0046982	Function	Protein heterodimerization activity	IDA	25851604
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	25851604
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070476	Process	RRNA (guanine-N7)-methylation	IBA
GO:0070476	Process	RRNA (guanine-N7)-methylation	IEA
GO:0070476	Process	RRNA (guanine-N7)-methylation	IMP	25851604
GO:2000234	Process	Positive regulation of rRNA processing	IMP	25851604

Other IDs

• MIM: 615733
• HGNC: 16405
• e!Ensembl: ENSG00000071462

Protein

• UniProt ID: O43709
• Protein name: 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor)
• Protein function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed
• PDB: 6G4W , 7WTS , 7WTT , 7WTU , 7WTV , 7WTW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08241	Methyltransf_11	58 → 161	Methyltransferase domain	Domain
  PF12589	WBS_methylT	204 → 279	Methyltransferase involved in Williams-Beuren syndrome	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cel
• Sequence:

  MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDI
  GCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCI
  SISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
  AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMS
  RRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF

• Sequence length: 281

Pathways

Reactome Pathway

rRNA modification in the nucleus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Gastric cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WILLIAMS SYNDROME	—	Disgenet, Orphanet Disgenet, Orphanet	22036171, 17159124, 21855841, 12605447, 30414627, 21671373, 32976914, 33559318, 30323018	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (15)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	24086612	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	35088887	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29133897, 29888105		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35352485	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	28937628	Associate	★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	24488492	Inhibit	★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	24488492		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24488492		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	22147262	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial ischemia	Pubtator	31192914	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35088887	Associate	★☆☆☆☆ Found in Text Mining only
Williams Syndrome	Williams Syndrome	BEFREE	11978965, 30535232		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Williams Syndrome	Williams Syndrome	LHGDN	11978965		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Williams Syndrome	Williams syndrome	Pubtator	24086612	Inhibit	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Williams Syndrome	Williams syndrome	Pubtator	25525153	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

METTL27 1 shared diseaseWilliams syndrome 2 shared evidence sourcesDisgenet (Williams syndrome), Orphanet (Williams syndrome) Related via 1 shared disease including Williams syndrome — evidence mostly Disgenet. RFC2 1 shared diseaseWilliams syndrome 2 shared evidence sourcesDisgenet (Williams syndrome), Orphanet (Williams syndrome) Related via 1 shared disease including Williams syndrome — evidence mostly Disgenet. PNO1 2 shared pathwaysrRNA modification in the nucleus and cytosol, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including rRNA modification in the nucleus and cytosol, Major pathway of rRNA processing in the nucleolus and cytosol. CLIP2 1 shared diseaseWilliams syndrome 2 shared evidence sourcesDisgenet (Williams syndrome), Orphanet (Williams syndrome) Related via 1 shared disease including Williams syndrome — evidence mostly Disgenet. EIF4H 1 shared diseaseWilliams syndrome 2 shared evidence sourcesDisgenet (Williams syndrome), Orphanet (Williams syndrome) Related via 1 shared disease including Williams syndrome — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
METTL27	1	["Williams syndrome"]	0	[]	2	["Disgenet (Williams syndrome)","Orphanet (Williams syndrome)"]
RFC2	1	["Williams syndrome"]	0	[]	2	["Disgenet (Williams syndrome)","Orphanet (Williams syndrome)"]
PNO1	0	[]	2	["rRNA modification in the nucleus and cytosol","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
CLIP2	1	["Williams syndrome"]	0	[]	2	["Disgenet (Williams syndrome)","Orphanet (Williams syndrome)"]
EIF4H	1	["Williams syndrome"]	0	[]	2	["Disgenet (Williams syndrome)","Orphanet (Williams syndrome)"]

Diseases Linked via Similar Genes

Systemic lupus erythematosus Linked via 3 of 5 related genesRFC2, CLIP2, EIF4H Hypertension Linked via 1 of 5 related genesPNO1 Alzheimer disease Linked via 1 of 5 related genesCLIP2 Osteonecrosis Linked via 1 of 5 related genesCLIP2 Synovitis, acne, pustulosis, hyperostosis, and osteitis Linked via 1 of 5 related genesCLIP2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Systemic lupus erythematosus	3	["RFC2","CLIP2","EIF4H"]
Hypertension	1	["PNO1"]
Alzheimer disease	1	["CLIP2"]
Osteonecrosis	1	["CLIP2"]
Synovitis, acne, pustulosis, hyperostosis, and osteitis	1	["CLIP2"]