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Gene Gene information from NCBI Gene database.
Entrez ID 656
Gene name Bone morphogenetic protein 8b
Gene symbol BMP8B
Synonyms (NCBI Gene)
BMP8OP2
Chromosome 1
Chromosome location 1p34.2
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate
miRNA miRNA information provided by mirtarbase database.
495 Show/Hide all (495)
miRTarBase ID miRNA Experiments Reference
MIRT029797 hsa-miR-26b-5p Microarray 19088304
MIRT509133 hsa-miR-106a-5p PAR-CLIP 20371350
MIRT509132 hsa-miR-106b-5p PAR-CLIP 20371350
MIRT509131 hsa-miR-17-5p PAR-CLIP 20371350
MIRT509130 hsa-miR-20a-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development TAS 1460021
GO:0001503 Process Ossification IEA
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602284 1075 ENSG00000116985
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P34820
Protein name Bone morphogenetic protein 8B (BMP-8) (BMP-8B) (Osteogenic protein 2) (OP-2)
Protein function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00019 TGF_beta 300 → 401 Transforming growth factor beta like domain Domain
PF00688 TGFb_propeptide 29 → 251 TGF-beta propeptide Family
Sequence
Sequence length 402
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Hippo signaling pathway
Thermogenesis