ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55616
• Gene name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
• Gene symbol: ASAP3
• Synonyms (NCBI Gene): ACAP4, CENTB6, DDEFL1, UPLC1
• Chromosome: 1
• Chromosome location: 1p36.12
• Summary: This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf pr

miRNA Show/Hide all (299)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018191	hsa-miR-335-5p	Microarray	18185580
MIRT539081	hsa-miR-3667-5p	PAR-CLIP	22012620
MIRT539080	hsa-miR-548ao-3p	PAR-CLIP	22012620
MIRT539078	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT539079	hsa-miR-208a-3p	PAR-CLIP	22012620
MIRT539077	hsa-miR-208b-3p	PAR-CLIP	22012620
MIRT539076	hsa-miR-499a-5p	PAR-CLIP	22012620
MIRT539081	hsa-miR-3667-5p	PAR-CLIP	22012620
MIRT539080	hsa-miR-548ao-3p	PAR-CLIP	22012620
MIRT539078	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT539079	hsa-miR-208a-3p	PAR-CLIP	22012620
MIRT539077	hsa-miR-208b-3p	PAR-CLIP	22012620
MIRT539076	hsa-miR-499a-5p	PAR-CLIP	22012620
MIRT755799	miR-149	Luciferase reporter assay, Western blotting, qRT-PCR, RNA-seq	36193254
MIRT801835	hsa-miR-3126-5p	CLIP-seq
MIRT801836	hsa-miR-3199	CLIP-seq
MIRT801837	hsa-miR-4419a	CLIP-seq
MIRT801838	hsa-miR-4502	CLIP-seq
MIRT801839	hsa-miR-4510	CLIP-seq
MIRT801840	hsa-miR-4693-3p	CLIP-seq
MIRT801841	hsa-miR-4740-5p	CLIP-seq
MIRT801842	hsa-miR-1207-5p	CLIP-seq
MIRT801843	hsa-miR-208a	CLIP-seq
MIRT801844	hsa-miR-208b	CLIP-seq
MIRT801845	hsa-miR-3185	CLIP-seq
MIRT801846	hsa-miR-3189-3p	CLIP-seq
MIRT801847	hsa-miR-3529	CLIP-seq
MIRT801848	hsa-miR-3622b-5p	CLIP-seq
MIRT801849	hsa-miR-3688-5p	CLIP-seq
MIRT801850	hsa-miR-379	CLIP-seq
MIRT801851	hsa-miR-3938	CLIP-seq
MIRT801852	hsa-miR-4256	CLIP-seq
MIRT801853	hsa-miR-4451	CLIP-seq
MIRT801854	hsa-miR-4493	CLIP-seq
MIRT801855	hsa-miR-4650-3p	CLIP-seq
MIRT801856	hsa-miR-4725-5p	CLIP-seq
MIRT801857	hsa-miR-4736	CLIP-seq
MIRT801858	hsa-miR-4753-5p	CLIP-seq
MIRT801859	hsa-miR-4763-3p	CLIP-seq
MIRT801860	hsa-miR-499-5p	CLIP-seq
MIRT801861	hsa-miR-504	CLIP-seq
MIRT1936758	hsa-miR-1303	CLIP-seq
MIRT1936759	hsa-miR-143	CLIP-seq
MIRT1936760	hsa-miR-198	CLIP-seq
MIRT1936761	hsa-miR-3591-5p	CLIP-seq
MIRT1936762	hsa-miR-3606	CLIP-seq
MIRT1936763	hsa-miR-3673	CLIP-seq
MIRT1936764	hsa-miR-376c	CLIP-seq
MIRT1936765	hsa-miR-4765	CLIP-seq
MIRT1936766	hsa-miR-4770	CLIP-seq
MIRT1936767	hsa-miR-500a	CLIP-seq
MIRT1936768	hsa-miR-501-5p	CLIP-seq
MIRT1936769	hsa-miR-571	CLIP-seq
MIRT1936770	hsa-miR-921	CLIP-seq
MIRT1936759	hsa-miR-143	CLIP-seq
MIRT1936760	hsa-miR-198	CLIP-seq
MIRT2176540	hsa-miR-3135	CLIP-seq
MIRT2176541	hsa-miR-371b-5p	CLIP-seq
MIRT1936764	hsa-miR-376c	CLIP-seq
MIRT2176542	hsa-miR-4267	CLIP-seq
MIRT2176543	hsa-miR-4283	CLIP-seq
MIRT2176544	hsa-miR-4437	CLIP-seq
MIRT2176545	hsa-miR-4488	CLIP-seq
MIRT2176546	hsa-miR-4505	CLIP-seq
MIRT2176547	hsa-miR-4697-5p	CLIP-seq
MIRT2176548	hsa-miR-4747-5p	CLIP-seq
MIRT1936766	hsa-miR-4770	CLIP-seq
MIRT1936769	hsa-miR-571	CLIP-seq
MIRT2176549	hsa-miR-637	CLIP-seq
MIRT2384507	hsa-miR-3158-3p	CLIP-seq
MIRT2384508	hsa-miR-4446-3p	CLIP-seq
MIRT2384509	hsa-miR-4492	CLIP-seq
MIRT2384510	hsa-miR-4498	CLIP-seq
MIRT2176546	hsa-miR-4505	CLIP-seq
MIRT2384511	hsa-miR-4646-5p	CLIP-seq
MIRT2176548	hsa-miR-4747-5p	CLIP-seq
MIRT2384512	hsa-miR-762	CLIP-seq
MIRT2479890	hsa-miR-10a	CLIP-seq
MIRT2479891	hsa-miR-10b	CLIP-seq
MIRT2479892	hsa-miR-1184	CLIP-seq
MIRT2479893	hsa-miR-1205	CLIP-seq
MIRT801842	hsa-miR-1207-5p	CLIP-seq
MIRT2479894	hsa-miR-1252	CLIP-seq
MIRT2479895	hsa-miR-1253	CLIP-seq
MIRT2479896	hsa-miR-125a-5p	CLIP-seq
MIRT2479897	hsa-miR-125b	CLIP-seq
MIRT2479898	hsa-miR-1264	CLIP-seq
MIRT2479899	hsa-miR-1273f	CLIP-seq
MIRT2479900	hsa-miR-1273g	CLIP-seq
MIRT2479901	hsa-miR-1283	CLIP-seq
MIRT2479902	hsa-miR-1292	CLIP-seq
MIRT2479903	hsa-miR-1299	CLIP-seq
MIRT2479904	hsa-miR-1301	CLIP-seq
MIRT2479905	hsa-miR-135a	CLIP-seq
MIRT2479906	hsa-miR-135b	CLIP-seq
MIRT2479907	hsa-miR-140-3p	CLIP-seq
MIRT2479908	hsa-miR-140-5p	CLIP-seq
MIRT1936759	hsa-miR-143	CLIP-seq
MIRT2479909	hsa-miR-151-3p	CLIP-seq
MIRT2479910	hsa-miR-1910	CLIP-seq
MIRT2479911	hsa-miR-1914	CLIP-seq
MIRT2479912	hsa-miR-1915	CLIP-seq
MIRT1936760	hsa-miR-198	CLIP-seq
MIRT801843	hsa-miR-208a	CLIP-seq
MIRT801844	hsa-miR-208b	CLIP-seq
MIRT2479913	hsa-miR-2110	CLIP-seq
MIRT2479914	hsa-miR-2114	CLIP-seq
MIRT2479915	hsa-miR-2355-5p	CLIP-seq
MIRT2479916	hsa-miR-3064-5p	CLIP-seq
MIRT2479917	hsa-miR-31	CLIP-seq
MIRT2479918	hsa-miR-3133	CLIP-seq
MIRT2176540	hsa-miR-3135	CLIP-seq
MIRT2384507	hsa-miR-3158-3p	CLIP-seq
MIRT2479919	hsa-miR-3158-5p	CLIP-seq
MIRT2479920	hsa-miR-3160-5p	CLIP-seq
MIRT2479921	hsa-miR-3162-3p	CLIP-seq
MIRT2479922	hsa-miR-3545-5p	CLIP-seq
MIRT1936761	hsa-miR-3591-5p	CLIP-seq
MIRT1936762	hsa-miR-3606	CLIP-seq
MIRT2479923	hsa-miR-3652	CLIP-seq
MIRT2479924	hsa-miR-3664-3p	CLIP-seq
MIRT1936763	hsa-miR-3673	CLIP-seq
MIRT2479925	hsa-miR-3682-3p	CLIP-seq
MIRT2479926	hsa-miR-3692	CLIP-seq
MIRT2176541	hsa-miR-371b-5p	CLIP-seq
MIRT1936764	hsa-miR-376c	CLIP-seq
MIRT2479927	hsa-miR-3908	CLIP-seq
MIRT2479928	hsa-miR-3925-3p	CLIP-seq
MIRT801851	hsa-miR-3938	CLIP-seq
MIRT2479929	hsa-miR-4251	CLIP-seq
MIRT2479930	hsa-miR-4260	CLIP-seq
MIRT2479931	hsa-miR-4261	CLIP-seq
MIRT2176542	hsa-miR-4267	CLIP-seq
MIRT2479932	hsa-miR-4271	CLIP-seq
MIRT2176543	hsa-miR-4283	CLIP-seq
MIRT2479933	hsa-miR-4319	CLIP-seq
MIRT2479934	hsa-miR-4326	CLIP-seq
MIRT2479935	hsa-miR-4330	CLIP-seq
MIRT2479936	hsa-miR-4430	CLIP-seq
MIRT2479937	hsa-miR-4433	CLIP-seq
MIRT2176544	hsa-miR-4437	CLIP-seq
MIRT2384508	hsa-miR-4446-3p	CLIP-seq
MIRT2479938	hsa-miR-4459	CLIP-seq
MIRT2479939	hsa-miR-4460	CLIP-seq
MIRT2479940	hsa-miR-4471	CLIP-seq
MIRT2176545	hsa-miR-4488	CLIP-seq
MIRT2479941	hsa-miR-4489	CLIP-seq
MIRT2384509	hsa-miR-4492	CLIP-seq
MIRT2479942	hsa-miR-4496	CLIP-seq
MIRT2384510	hsa-miR-4498	CLIP-seq
MIRT2176546	hsa-miR-4505	CLIP-seq
MIRT2479943	hsa-miR-4514	CLIP-seq
MIRT2479944	hsa-miR-4522	CLIP-seq
MIRT2479945	hsa-miR-455-3p	CLIP-seq
MIRT2479946	hsa-miR-4645-5p	CLIP-seq
MIRT2384511	hsa-miR-4646-5p	CLIP-seq
MIRT2479947	hsa-miR-4648	CLIP-seq
MIRT2479948	hsa-miR-4654	CLIP-seq
MIRT2479949	hsa-miR-4656	CLIP-seq
MIRT2479950	hsa-miR-4660	CLIP-seq
MIRT2479951	hsa-miR-4663	CLIP-seq
MIRT2479952	hsa-miR-4667-5p	CLIP-seq
MIRT2479953	hsa-miR-4673	CLIP-seq
MIRT2479954	hsa-miR-4685-5p	CLIP-seq
MIRT2479955	hsa-miR-4686	CLIP-seq
MIRT2479956	hsa-miR-4691-3p	CLIP-seq
MIRT2479957	hsa-miR-4692	CLIP-seq
MIRT801840	hsa-miR-4693-3p	CLIP-seq
MIRT2479958	hsa-miR-4694-3p	CLIP-seq
MIRT2176547	hsa-miR-4697-5p	CLIP-seq
MIRT2479959	hsa-miR-4700-5p	CLIP-seq
MIRT2479960	hsa-miR-4708-5p	CLIP-seq
MIRT2479961	hsa-miR-4725-3p	CLIP-seq
MIRT801856	hsa-miR-4725-5p	CLIP-seq
MIRT2479962	hsa-miR-4726-3p	CLIP-seq
MIRT2479963	hsa-miR-4727-3p	CLIP-seq
MIRT2479964	hsa-miR-4731-5p	CLIP-seq
MIRT2479965	hsa-miR-4732-3p	CLIP-seq
MIRT801857	hsa-miR-4736	CLIP-seq
MIRT2176548	hsa-miR-4747-5p	CLIP-seq
MIRT2479966	hsa-miR-4755-3p	CLIP-seq
MIRT801859	hsa-miR-4763-3p	CLIP-seq
MIRT2479967	hsa-miR-4768-3p	CLIP-seq
MIRT2479968	hsa-miR-4769-5p	CLIP-seq
MIRT1936766	hsa-miR-4770	CLIP-seq
MIRT2479969	hsa-miR-4781-5p	CLIP-seq
MIRT2479970	hsa-miR-4786-3p	CLIP-seq
MIRT801860	hsa-miR-499-5p	CLIP-seq
MIRT801861	hsa-miR-504	CLIP-seq
MIRT2479971	hsa-miR-5047	CLIP-seq
MIRT2479972	hsa-miR-522	CLIP-seq
MIRT2479973	hsa-miR-544	CLIP-seq
MIRT2479974	hsa-miR-548b-3p	CLIP-seq
MIRT2479975	hsa-miR-563	CLIP-seq
MIRT1936769	hsa-miR-571	CLIP-seq
MIRT2479976	hsa-miR-626	CLIP-seq
MIRT2176549	hsa-miR-637	CLIP-seq
MIRT2479977	hsa-miR-647	CLIP-seq
MIRT2479978	hsa-miR-670	CLIP-seq
MIRT2384512	hsa-miR-762	CLIP-seq
MIRT2479979	hsa-miR-766	CLIP-seq
MIRT2479980	hsa-miR-875-3p	CLIP-seq
MIRT2479981	hsa-miR-890	CLIP-seq
MIRT1936770	hsa-miR-921	CLIP-seq
MIRT2479890	hsa-miR-10a	CLIP-seq
MIRT2479891	hsa-miR-10b	CLIP-seq
MIRT2479892	hsa-miR-1184	CLIP-seq
MIRT2479893	hsa-miR-1205	CLIP-seq
MIRT2479894	hsa-miR-1252	CLIP-seq
MIRT2479898	hsa-miR-1264	CLIP-seq
MIRT2479899	hsa-miR-1273f	CLIP-seq
MIRT2479900	hsa-miR-1273g	CLIP-seq
MIRT2479901	hsa-miR-1283	CLIP-seq
MIRT2479902	hsa-miR-1292	CLIP-seq
MIRT2479904	hsa-miR-1301	CLIP-seq
MIRT2479905	hsa-miR-135a	CLIP-seq
MIRT2479906	hsa-miR-135b	CLIP-seq
MIRT2479907	hsa-miR-140-3p	CLIP-seq
MIRT2479908	hsa-miR-140-5p	CLIP-seq
MIRT1936759	hsa-miR-143	CLIP-seq
MIRT2479909	hsa-miR-151-3p	CLIP-seq
MIRT2479911	hsa-miR-1914	CLIP-seq
MIRT2479912	hsa-miR-1915	CLIP-seq
MIRT1936760	hsa-miR-198	CLIP-seq
MIRT2479913	hsa-miR-2110	CLIP-seq
MIRT2479915	hsa-miR-2355-5p	CLIP-seq
MIRT2479917	hsa-miR-31	CLIP-seq
MIRT2479918	hsa-miR-3133	CLIP-seq
MIRT2384507	hsa-miR-3158-3p	CLIP-seq
MIRT2479919	hsa-miR-3158-5p	CLIP-seq
MIRT2479920	hsa-miR-3160-5p	CLIP-seq
MIRT2479922	hsa-miR-3545-5p	CLIP-seq
MIRT1936761	hsa-miR-3591-5p	CLIP-seq
MIRT1936762	hsa-miR-3606	CLIP-seq
MIRT2479923	hsa-miR-3652	CLIP-seq
MIRT2479924	hsa-miR-3664-3p	CLIP-seq
MIRT1936763	hsa-miR-3673	CLIP-seq
MIRT2479925	hsa-miR-3682-3p	CLIP-seq
MIRT2176541	hsa-miR-371b-5p	CLIP-seq
MIRT1936764	hsa-miR-376c	CLIP-seq
MIRT2479927	hsa-miR-3908	CLIP-seq
MIRT2479928	hsa-miR-3925-3p	CLIP-seq
MIRT2479930	hsa-miR-4260	CLIP-seq
MIRT2479931	hsa-miR-4261	CLIP-seq
MIRT2176542	hsa-miR-4267	CLIP-seq
MIRT2479932	hsa-miR-4271	CLIP-seq
MIRT2176543	hsa-miR-4283	CLIP-seq
MIRT2479934	hsa-miR-4326	CLIP-seq
MIRT2479935	hsa-miR-4330	CLIP-seq
MIRT2479936	hsa-miR-4430	CLIP-seq
MIRT2479937	hsa-miR-4433	CLIP-seq
MIRT2176544	hsa-miR-4437	CLIP-seq
MIRT2384508	hsa-miR-4446-3p	CLIP-seq
MIRT2479938	hsa-miR-4459	CLIP-seq
MIRT2479939	hsa-miR-4460	CLIP-seq
MIRT2479940	hsa-miR-4471	CLIP-seq
MIRT2176545	hsa-miR-4488	CLIP-seq
MIRT2479941	hsa-miR-4489	CLIP-seq
MIRT2384509	hsa-miR-4492	CLIP-seq
MIRT2479942	hsa-miR-4496	CLIP-seq
MIRT2384510	hsa-miR-4498	CLIP-seq
MIRT2176546	hsa-miR-4505	CLIP-seq
MIRT2479944	hsa-miR-4522	CLIP-seq
MIRT2384511	hsa-miR-4646-5p	CLIP-seq
MIRT2479947	hsa-miR-4648	CLIP-seq
MIRT2479948	hsa-miR-4654	CLIP-seq
MIRT2479949	hsa-miR-4656	CLIP-seq
MIRT2479950	hsa-miR-4660	CLIP-seq
MIRT2479951	hsa-miR-4663	CLIP-seq
MIRT2479952	hsa-miR-4667-5p	CLIP-seq
MIRT2479954	hsa-miR-4685-5p	CLIP-seq
MIRT2479955	hsa-miR-4686	CLIP-seq
MIRT2479956	hsa-miR-4691-3p	CLIP-seq
MIRT801840	hsa-miR-4693-3p	CLIP-seq
MIRT2176547	hsa-miR-4697-5p	CLIP-seq
MIRT2479959	hsa-miR-4700-5p	CLIP-seq
MIRT2479960	hsa-miR-4708-5p	CLIP-seq
MIRT2479961	hsa-miR-4725-3p	CLIP-seq
MIRT2479962	hsa-miR-4726-3p	CLIP-seq
MIRT2479963	hsa-miR-4727-3p	CLIP-seq
MIRT2479964	hsa-miR-4731-5p	CLIP-seq
MIRT2176548	hsa-miR-4747-5p	CLIP-seq
MIRT2479966	hsa-miR-4755-3p	CLIP-seq
MIRT2479967	hsa-miR-4768-3p	CLIP-seq
MIRT2479968	hsa-miR-4769-5p	CLIP-seq
MIRT1936766	hsa-miR-4770	CLIP-seq
MIRT2479969	hsa-miR-4781-5p	CLIP-seq
MIRT2479970	hsa-miR-4786-3p	CLIP-seq
MIRT2479971	hsa-miR-5047	CLIP-seq
MIRT2479973	hsa-miR-544	CLIP-seq
MIRT2479974	hsa-miR-548b-3p	CLIP-seq
MIRT2479975	hsa-miR-563	CLIP-seq
MIRT1936769	hsa-miR-571	CLIP-seq
MIRT2675492	hsa-miR-593	CLIP-seq
MIRT2176549	hsa-miR-637	CLIP-seq
MIRT2479977	hsa-miR-647	CLIP-seq
MIRT2384512	hsa-miR-762	CLIP-seq
MIRT2479979	hsa-miR-766	CLIP-seq
MIRT1936770	hsa-miR-921	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IBA
GO:0001726	Component	Ruffle	IDA	18400762
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	18400762
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	19380743, 25416956, 26871637, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005925	Component	Focal adhesion	IBA
GO:0005925	Component	Focal adhesion	IDA	18400762
GO:0005925	Component	Focal adhesion	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016477	Process	Cell migration	IEA
GO:0016477	Process	Cell migration	IMP	18400762
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	18400762
GO:0046872	Function	Metal ion binding	IEA
GO:0051492	Process	Regulation of stress fiber assembly	IBA
GO:0051492	Process	Regulation of stress fiber assembly	IMP	18400762

Other IDs

• MIM: 616594
• HGNC: 14987
• e!Ensembl: ENSG00000088280

Protein

• UniProt ID: Q8TDY4
• Protein name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)
• Protein function: Promotes cell proliferation.
• PDB: 2B0O , 3LVQ , 3LVR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	303 → 394	PH domain	Domain
  PF01412	ArfGap	426 → 544	Putative GTPase activating protein for Arf	Domain
  PF12796	Ank_2	590 → 682	Ankyrin repeats (3 copies)	Repeat
  PF16746	BAR_3	32 → 261		Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes. {ECO:0000269|PubMed:14654939}.
• Sequence:

  MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR
  AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL
  NNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKERDRARVTGGIPGEVAQ
  DMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFI
  EKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQ
  FGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEK
  KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGE
  PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQS
  LTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF
  ARRCTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQA
  SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD
  IARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAH
  WASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVS
  SLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS
  EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQL
  LQD

• Sequence length: 903

Pathways

KEGG Pathway

Endocytosis

Fc gamma R-mediated phagocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Nonpapillary renal cell carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (20)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31410024		★☆☆☆☆ Found in Text Mining only
Adult Hepatocellular Carcinoma	Liver carcinoma	BEFREE	29348842		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29348842, 30395269		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24078447, 29348842		★☆☆☆☆ Found in Text Mining only
Childhood Hepatocellular Carcinoma	Liver carcinoma	BEFREE	29348842		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	28502111		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	28502111		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28502111, 30536996		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30536996	Associate	★☆☆☆☆ Found in Text Mining only
Congenital anomaly of brain	Brain malformation	BEFREE	24284654		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	14654939, 18400762, 29348842, 31410024		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24078447	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29348842, 30395269		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	29348842		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24078447, 29348842		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24078447, 24284654		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	28502111		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24078447		★☆☆☆☆ Found in Text Mining only
Peptic Ulcer	Peptic Ulcer	BEFREE	29263912		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ASAP2 2 shared pathwaysEndocytosis, Fc gamma R-mediated phagocytosis Related via 2 shared pathways including Endocytosis, Fc gamma R-mediated phagocytosis. AMPH 2 shared pathwaysEndocytosis, Fc gamma R-mediated phagocytosis Related via 2 shared pathways including Endocytosis, Fc gamma R-mediated phagocytosis. BIN1 2 shared pathwaysEndocytosis, Fc gamma R-mediated phagocytosis Related via 2 shared pathways including Endocytosis, Fc gamma R-mediated phagocytosis. ASAP1 2 shared pathwaysEndocytosis, Fc gamma R-mediated phagocytosis Related via 2 shared pathways including Endocytosis, Fc gamma R-mediated phagocytosis. ACTR3B 2 shared pathwaysEndocytosis, Fc gamma R-mediated phagocytosis Related via 2 shared pathways including Endocytosis, Fc gamma R-mediated phagocytosis.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ASAP2	0	[]	2	["Endocytosis","Fc gamma R-mediated phagocytosis"]	0	[]
AMPH	0	[]	2	["Endocytosis","Fc gamma R-mediated phagocytosis"]	0	[]
BIN1	0	[]	2	["Endocytosis","Fc gamma R-mediated phagocytosis"]	0	[]
ASAP1	0	[]	2	["Endocytosis","Fc gamma R-mediated phagocytosis"]	0	[]
ACTR3B	0	[]	2	["Endocytosis","Fc gamma R-mediated phagocytosis"]	0	[]

Diseases Linked via Similar Genes

Ulcerative colitis Linked via 3 of 5 related genesASAP2, BIN1, ACTR3B Asthma Linked via 2 of 5 related genesASAP2, ASAP1 Crohn disease Linked via 2 of 5 related genesASAP2, BIN1 Multiple sclerosis Linked via 2 of 5 related genesASAP2, ASAP1 Oligodendroglioma Linked via 2 of 5 related genesASAP2, BIN1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Ulcerative colitis	3	["ASAP2","BIN1","ACTR3B"]
Asthma	2	["ASAP2","ASAP1"]
Crohn disease	2	["ASAP2","BIN1"]
Multiple sclerosis	2	["ASAP2","ASAP1"]
Oligodendroglioma	2	["ASAP2","BIN1"]