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Gene Gene information from NCBI Gene database.
Entrez ID 200316
Gene name Apolipoprotein B mRNA editing enzyme catalytic subunit 3F
Gene symbol APOBEC3F
Synonyms (NCBI Gene)
A3FARP8BK150C2.4.MRNAKA6
Chromosome 22
Chromosome location 22q13.1
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and fu
miRNA miRNA information provided by mirtarbase database.
653 Show/Hide all (653)
miRTarBase ID miRNA Experiments Reference
MIRT695054 hsa-miR-483-5p HITS-CLIP 23313552
MIRT664173 hsa-miR-383-3p HITS-CLIP 23313552
MIRT695053 hsa-miR-6089 HITS-CLIP 23313552
MIRT695052 hsa-miR-363-5p HITS-CLIP 23313552
MIRT695051 hsa-miR-6745 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41 Show/Hide all (41)
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IBA
GO:0000932 Component P-body IDA 16699599, 22915799
GO:0000932 Component P-body IEA
GO:0002230 Process Positive regulation of defense response to virus by host IDA 17121840
GO:0002376 Process Immune system process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608993 17356 ENSG00000128394
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IUX4
Protein name DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)
Protein function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:15141007, PubMed:20062055, PubMed:22915799, PubMed:34774569). Exhibi
PDB 3WUS , 4IOU , 4J4J , 5HX4 , 5HX5 , 5W2M , 5ZVA , 5ZVB , 6NIL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08210 APOBEC_N 200 → 370 APOBEC-like N-terminal domain Domain
PF18782 NAD2 10 → 188 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly expressed in ovary. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:15152192, ECO:0000269|PubMed:20308164}.
Sequence
Sequence length 373
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Viral life cycle - HIV-1
Human immunodeficiency virus 1 infection