Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10930
Gene name	Apolipoprotein B mRNA editing enzyme catalytic subunit 2
Gene symbol	APOBEC2
Synonyms (NCBI Gene)	ARCD1ARP1
Chromosome	6
Chromosome location	6p21.1

30 Show/Hide all (30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT735179	hsa-miR-122-3p	Luciferase reporter assayWestern blottingqRT-PCR	31485598
MIRT789783	hsa-miR-103a	CLIP-seq
MIRT789784	hsa-miR-103b	CLIP-seq
MIRT789785	hsa-miR-107	CLIP-seq
MIRT789786	hsa-miR-1254	CLIP-seq
MIRT789787	hsa-miR-1303	CLIP-seq
MIRT789788	hsa-miR-135a	CLIP-seq
MIRT789789	hsa-miR-135b	CLIP-seq
MIRT789790	hsa-miR-15a	CLIP-seq
MIRT789791	hsa-miR-15b	CLIP-seq
MIRT789792	hsa-miR-16	CLIP-seq
MIRT789793	hsa-miR-195	CLIP-seq
MIRT789794	hsa-miR-2278	CLIP-seq
MIRT789795	hsa-miR-3116	CLIP-seq
MIRT789796	hsa-miR-3665	CLIP-seq
MIRT789797	hsa-miR-376a	CLIP-seq
MIRT789798	hsa-miR-376b	CLIP-seq
MIRT789799	hsa-miR-424	CLIP-seq
MIRT789800	hsa-miR-4293	CLIP-seq
MIRT789801	hsa-miR-4310	CLIP-seq
MIRT789802	hsa-miR-4768-5p	CLIP-seq
MIRT789803	hsa-miR-497	CLIP-seq
MIRT789804	hsa-miR-502-5p	CLIP-seq
MIRT789805	hsa-miR-596	CLIP-seq
MIRT789806	hsa-miR-657	CLIP-seq
MIRT789807	hsa-miR-659	CLIP-seq
MIRT1932947	hsa-miR-4476	CLIP-seq
MIRT1932948	hsa-miR-7	CLIP-seq
MIRT1932947	hsa-miR-4476	CLIP-seq
MIRT1932948	hsa-miR-7	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS	10403781
GO:0003824	Function	Catalytic activity	IEA
GO:0004126	Function	Cytidine deaminase activity	IBA
GO:0004126	Function	Cytidine deaminase activity	IDA	10403781
GO:0004126	Function	Cytidine deaminase activity	IEA
GO:0004126	Function	Cytidine deaminase activity	TAS	10403781
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0006397	Process	MRNA processing	IEA
GO:0010556	Process	Regulation of macromolecule biosynthetic process	IEA
GO:0016554	Process	Cytidine to uridine editing	IBA
GO:0016554	Process	Cytidine to uridine editing	IDA	10403781
GO:0016554	Process	Cytidine to uridine editing	IEA
GO:0016554	Process	Cytidine to uridine editing	IEA
GO:0016556	Process	MRNA modification	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	17187054
GO:0044029	Process	Positive regulation of gene expression via chromosomal CpG island demethylation	IDA	21496894
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
604797	605	ENSG00000124701

Q9Y235

Protein name

C->U-editing enzyme APOBEC-2 (EC 3.5.4.36) (mRNA(cytosine(6666)) deaminase 2)

Protein function

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression throug

PDB

2NYT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05240	APOBEC_C	143 → 223		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed exclusively in heart and skeletal muscle.

Sequence

MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVE
YSSGRNKTFLCYVVEAQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVT
WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK

Sequence length

224

Interactions

View interactions

Reactome Pathway
mRNA Editing: C to U Conversion
Formation of the Editosome

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (15)
Acute leukemia	Leukemia	BEFREE	9539779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	38166744	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	8782080		★★★★★ ★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	20138841		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	23925294		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	31340720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	1321332, 21469143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	1321332		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	21469143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31485598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	26976208, 30701025, 31213901, 9454907		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	29127187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31485598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia Type 5	Spinocerebellar Ataxia	BEFREE	20603325		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38166744	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2)

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