AMOTL2 (angiomotin like 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51421 |
| Gene name | Angiomotin like 2 |
| Gene symbol | AMOTL2 |
| Synonyms (NCBI Gene) |
LCCP
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| Chromosome | 3 |
| Chromosome location | 3q22.2 |
| Summary | Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this |
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miRNA
miRNA information provided by mirtarbase database.
656
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9Y2J4 | ||||||||||
| Protein name | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | ||||||||||
| Protein function | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore requir | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 779 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with AMOTL2 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to AMOTL2 (see Related Genes above), that are NOT already directly curated for AMOTL2 itself -- a lead worth checking, not a confirmed association.
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