ALPI (alkaline phosphatase, intestinal)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 248
• Gene name: Alkaline phosphatase, intestinal
• Gene symbol: ALPI
• Synonyms (NCBI Gene): IAP
• Chromosome: 2
• Chromosome location: 2q37.1
• Summary: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a comp

miRNA Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019330	hsa-miR-148b-3p	Microarray	17612493
MIRT029513	hsa-miR-26b-5p	Microarray	19088304
MIRT695519	hsa-miR-3200-5p	HITS-CLIP	23313552
MIRT695518	hsa-miR-4682	HITS-CLIP	23313552
MIRT695517	hsa-miR-6128	HITS-CLIP	23313552
MIRT695516	hsa-miR-637	HITS-CLIP	23313552
MIRT695515	hsa-miR-4481	HITS-CLIP	23313552
MIRT695514	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT695513	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT695512	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT695511	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT695510	hsa-miR-206	HITS-CLIP	23313552
MIRT695509	hsa-miR-613	HITS-CLIP	23313552
MIRT695508	hsa-miR-7974	HITS-CLIP	23313552
MIRT695507	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695506	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT695505	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT695504	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695503	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695502	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695501	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695500	hsa-miR-134-5p	HITS-CLIP	23313552
MIRT695499	hsa-miR-3118	HITS-CLIP	23313552
MIRT695498	hsa-miR-3164	HITS-CLIP	23313552
MIRT695497	hsa-miR-6820-3p	HITS-CLIP	23313552
MIRT695496	hsa-miR-1238-5p	HITS-CLIP	23313552
MIRT695495	hsa-miR-4758-5p	HITS-CLIP	23313552
MIRT695494	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT695519	hsa-miR-3200-5p	HITS-CLIP	23313552
MIRT695518	hsa-miR-4682	HITS-CLIP	23313552
MIRT695517	hsa-miR-6128	HITS-CLIP	23313552
MIRT695516	hsa-miR-637	HITS-CLIP	23313552
MIRT695515	hsa-miR-4481	HITS-CLIP	23313552
MIRT695514	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT695513	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT695512	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT695511	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT695510	hsa-miR-206	HITS-CLIP	23313552
MIRT695509	hsa-miR-613	HITS-CLIP	23313552
MIRT695508	hsa-miR-7974	HITS-CLIP	23313552
MIRT695507	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695506	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT695505	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT695504	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695503	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695502	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695501	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695500	hsa-miR-134-5p	HITS-CLIP	23313552
MIRT695499	hsa-miR-3118	HITS-CLIP	23313552
MIRT695498	hsa-miR-3164	HITS-CLIP	23313552
MIRT695497	hsa-miR-6820-3p	HITS-CLIP	23313552
MIRT695496	hsa-miR-1238-5p	HITS-CLIP	23313552
MIRT695495	hsa-miR-4758-5p	HITS-CLIP	23313552
MIRT695494	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT778940	hsa-miR-1231	CLIP-seq
MIRT778941	hsa-miR-204	CLIP-seq
MIRT778942	hsa-miR-211	CLIP-seq
MIRT778943	hsa-miR-24	CLIP-seq
MIRT778944	hsa-miR-2467-3p	CLIP-seq
MIRT778945	hsa-miR-3169	CLIP-seq
MIRT778946	hsa-miR-3175	CLIP-seq
MIRT778947	hsa-miR-331-3p	CLIP-seq
MIRT778948	hsa-miR-342-5p	CLIP-seq
MIRT778949	hsa-miR-3664-3p	CLIP-seq
MIRT778950	hsa-miR-4288	CLIP-seq
MIRT778951	hsa-miR-4292	CLIP-seq
MIRT778952	hsa-miR-4467	CLIP-seq
MIRT778953	hsa-miR-4646-5p	CLIP-seq
MIRT778954	hsa-miR-4651	CLIP-seq
MIRT778955	hsa-miR-4664-5p	CLIP-seq
MIRT778956	hsa-miR-4667-5p	CLIP-seq
MIRT778957	hsa-miR-4700-5p	CLIP-seq
MIRT778958	hsa-miR-4712-5p	CLIP-seq
MIRT778959	hsa-miR-4795-5p	CLIP-seq
MIRT778960	hsa-miR-592	CLIP-seq
MIRT778961	hsa-miR-597	CLIP-seq
MIRT778962	hsa-miR-608	CLIP-seq
MIRT778963	hsa-miR-632	CLIP-seq
MIRT778964	hsa-miR-639	CLIP-seq
MIRT778965	hsa-miR-770-5p	CLIP-seq
MIRT778966	hsa-miR-892a	CLIP-seq
MIRT778967	hsa-miR-922	CLIP-seq
MIRT2170697	hsa-miR-125a-3p	CLIP-seq
MIRT2170698	hsa-miR-133a	CLIP-seq
MIRT2170699	hsa-miR-133b	CLIP-seq
MIRT2170700	hsa-miR-3934	CLIP-seq
MIRT2170701	hsa-miR-4281	CLIP-seq
MIRT2170702	hsa-miR-764	CLIP-seq
MIRT2170698	hsa-miR-133a	CLIP-seq
MIRT2170699	hsa-miR-133b	CLIP-seq
MIRT778943	hsa-miR-24	CLIP-seq
MIRT2384094	hsa-miR-326	CLIP-seq
MIRT2384095	hsa-miR-330-5p	CLIP-seq
MIRT778952	hsa-miR-4467	CLIP-seq
MIRT778959	hsa-miR-4795-5p	CLIP-seq
MIRT2384096	hsa-miR-593	CLIP-seq
MIRT778964	hsa-miR-639	CLIP-seq
MIRT2170702	hsa-miR-764	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF4	Activation	12919939

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	ISS
GO:0002020	Function	Protease binding	IPI	18307834
GO:0004035	Function	Alkaline phosphatase activity	IBA
GO:0004035	Function	Alkaline phosphatase activity	IEA
GO:0004035	Function	Alkaline phosphatase activity	ISS
GO:0004035	Function	Alkaline phosphatase activity	NAS	2841341
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008270	Function	Zinc ion binding	ISS
GO:0016020	Component	Membrane	IEA
GO:0016311	Process	Dephosphorylation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 171740
• HGNC: 437
• e!Ensembl: ENSG00000163295

Protein

• UniProt ID: P09923
• Protein name: Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)
• Protein function: Alkaline phosphatase that can hydrolyze various phosphate compounds.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00245	Alk_phosphatase	52 → 487	Alkaline phosphatase	Domain

• Sequence:

  MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLG
  DGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLC
  GVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYA
  HTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADA
  SQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD
  PTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERA
  GQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF
  NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHV
  MAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP

• Sequence length: 528

Pathways

KEGG Pathway	Reactome Pathway
Thiamine metabolism	Synthesis of PA
Folate biosynthesis	Post-translational modification: synthesis of GPI-anchored proteins
Metabolic pathways	Digestion
Biosynthesis of cofactors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALPI-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Inflammatory bowel disease	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASES	—	Disgenet	29567797,32086639,32048120	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	34594039	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ALPL 1 shared diseaseUrolithiasis 4 shared pathwaysThiamine metabolism, Folate biosynthesis, Biosynthesis of cofactors, Post-translational modification: synthesis of GPI-anchored proteins 1 shared evidence sourceGWAS catalog (Urolithiasis) Related via 4 shared pathways including Thiamine metabolism, Folate biosynthesis — evidence mostly GWAS catalog. ALPG 4 shared pathwaysThiamine metabolism, Folate biosynthesis, Biosynthesis of cofactors, Post-translational modification: synthesis of GPI-anchored proteins Related via 4 shared pathways including Thiamine metabolism, Folate biosynthesis. ALPP 3 shared pathwaysThiamine metabolism, Folate biosynthesis, Biosynthesis of cofactors Related via 3 shared pathways including Thiamine metabolism, Folate biosynthesis. TPK1 2 shared pathwaysThiamine metabolism, Biosynthesis of cofactors Related via 2 shared pathways including Thiamine metabolism, Biosynthesis of cofactors. GCH1 2 shared pathwaysFolate biosynthesis, Biosynthesis of cofactors Related via 2 shared pathways including Folate biosynthesis, Biosynthesis of cofactors.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ALPL	1	["Urolithiasis"]	4	["Thiamine metabolism","Folate biosynthesis","Biosynthesis of cofactors","Post-translational modification: synthesis of GPI-anchored proteins"]	1	["GWAS catalog (Urolithiasis)"]
ALPG	0	[]	4	["Thiamine metabolism","Folate biosynthesis","Biosynthesis of cofactors","Post-translational modification: synthesis of GPI-anchored proteins"]	0	[]
ALPP	0	[]	3	["Thiamine metabolism","Folate biosynthesis","Biosynthesis of cofactors"]	0	[]
TPK1	0	[]	2	["Thiamine metabolism","Biosynthesis of cofactors"]	0	[]
GCH1	0	[]	2	["Folate biosynthesis","Biosynthesis of cofactors"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 2 of 5 related genesALPL, GCH1 Osteoarthritis Linked via 2 of 5 related genesALPL, GCH1 Hypophosphatasia Linked via 1 of 5 related genesALPL Aortic stenosis Linked via 1 of 5 related genesALPL Aortic valve disease Linked via 1 of 5 related genesALPL

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	2	["ALPL","GCH1"]
Osteoarthritis	2	["ALPL","GCH1"]
Hypophosphatasia	1	["ALPL"]
Aortic stenosis	1	["ALPL"]
Aortic valve disease	1	["ALPL"]