ADPGK (ADP dependent glucokinase)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83440
• Gene name: ADP dependent glucokinase
• Gene symbol: ADPGK
• Synonyms (NCBI Gene): 2610017G09Rik, ADP-GK
• Chromosome: 15
• Chromosome location: 15q24.1
• Summary: ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (254)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005179	hsa-miR-30a-5p	pSILAC	18668040
MIRT001393	hsa-miR-1-3p	pSILAC	18668040
MIRT001393	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT005179	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT029519	hsa-miR-26b-5p	Microarray	19088304
MIRT030526	hsa-miR-24-3p	Microarray	19748357
MIRT039172	hsa-miR-769-5p	CLASH	23622248
MIRT441257	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT441257	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT769643	hsa-miR-1226	CLIP-seq
MIRT769644	hsa-miR-1253	CLIP-seq
MIRT769645	hsa-miR-1266	CLIP-seq
MIRT769646	hsa-miR-1292	CLIP-seq
MIRT769647	hsa-miR-154	CLIP-seq
MIRT769648	hsa-miR-197	CLIP-seq
MIRT769649	hsa-miR-205	CLIP-seq
MIRT769650	hsa-miR-21	CLIP-seq
MIRT769651	hsa-miR-2278	CLIP-seq
MIRT769652	hsa-miR-24	CLIP-seq
MIRT769653	hsa-miR-3122	CLIP-seq
MIRT769654	hsa-miR-3140-3p	CLIP-seq
MIRT769655	hsa-miR-3157-5p	CLIP-seq
MIRT769656	hsa-miR-3185	CLIP-seq
MIRT769657	hsa-miR-3194-5p	CLIP-seq
MIRT769658	hsa-miR-3646	CLIP-seq
MIRT769659	hsa-miR-3664-3p	CLIP-seq
MIRT769660	hsa-miR-3682-3p	CLIP-seq
MIRT769661	hsa-miR-3690	CLIP-seq
MIRT769662	hsa-miR-383	CLIP-seq
MIRT769663	hsa-miR-3913-5p	CLIP-seq
MIRT769664	hsa-miR-3921	CLIP-seq
MIRT769665	hsa-miR-3925-3p	CLIP-seq
MIRT769666	hsa-miR-4251	CLIP-seq
MIRT769667	hsa-miR-4254	CLIP-seq
MIRT769668	hsa-miR-4267	CLIP-seq
MIRT769669	hsa-miR-4276	CLIP-seq
MIRT769670	hsa-miR-4422	CLIP-seq
MIRT769671	hsa-miR-4436a	CLIP-seq
MIRT769672	hsa-miR-4450	CLIP-seq
MIRT769673	hsa-miR-4471	CLIP-seq
MIRT769674	hsa-miR-4493	CLIP-seq
MIRT769675	hsa-miR-4499	CLIP-seq
MIRT769676	hsa-miR-4518	CLIP-seq
MIRT769677	hsa-miR-4633-3p	CLIP-seq
MIRT769678	hsa-miR-4635	CLIP-seq
MIRT769679	hsa-miR-4640-5p	CLIP-seq
MIRT769680	hsa-miR-4649-3p	CLIP-seq
MIRT769681	hsa-miR-4653-5p	CLIP-seq
MIRT769682	hsa-miR-4667-5p	CLIP-seq
MIRT769683	hsa-miR-4668-3p	CLIP-seq
MIRT769684	hsa-miR-4670-3p	CLIP-seq
MIRT769685	hsa-miR-4700-5p	CLIP-seq
MIRT769686	hsa-miR-4722-5p	CLIP-seq
MIRT769687	hsa-miR-4726-5p	CLIP-seq
MIRT769688	hsa-miR-4733-3p	CLIP-seq
MIRT769689	hsa-miR-4768-3p	CLIP-seq
MIRT769690	hsa-miR-4772-5p	CLIP-seq
MIRT769691	hsa-miR-4802-5p	CLIP-seq
MIRT769692	hsa-miR-502-5p	CLIP-seq
MIRT769693	hsa-miR-5096	CLIP-seq
MIRT769694	hsa-miR-513a-3p	CLIP-seq
MIRT769695	hsa-miR-515-5p	CLIP-seq
MIRT769696	hsa-miR-548c-3p	CLIP-seq
MIRT769697	hsa-miR-548g	CLIP-seq
MIRT769698	hsa-miR-570	CLIP-seq
MIRT769699	hsa-miR-590-5p	CLIP-seq
MIRT769700	hsa-miR-622	CLIP-seq
MIRT769701	hsa-miR-652	CLIP-seq
MIRT769702	hsa-miR-661	CLIP-seq
MIRT769703	hsa-miR-766	CLIP-seq
MIRT769672	hsa-miR-4450	CLIP-seq
MIRT769682	hsa-miR-4667-5p	CLIP-seq
MIRT769685	hsa-miR-4700-5p	CLIP-seq
MIRT769697	hsa-miR-548g	CLIP-seq
MIRT769701	hsa-miR-652	CLIP-seq
MIRT769644	hsa-miR-1253	CLIP-seq
MIRT769647	hsa-miR-154	CLIP-seq
MIRT1927040	hsa-miR-194	CLIP-seq
MIRT769651	hsa-miR-2278	CLIP-seq
MIRT769654	hsa-miR-3140-3p	CLIP-seq
MIRT1927041	hsa-miR-362-5p	CLIP-seq
MIRT1927042	hsa-miR-3688-3p	CLIP-seq
MIRT769665	hsa-miR-3925-3p	CLIP-seq
MIRT769666	hsa-miR-4251	CLIP-seq
MIRT769668	hsa-miR-4267	CLIP-seq
MIRT1927043	hsa-miR-4289	CLIP-seq
MIRT1927044	hsa-miR-433	CLIP-seq
MIRT1927045	hsa-miR-4438	CLIP-seq
MIRT769675	hsa-miR-4499	CLIP-seq
MIRT1927046	hsa-miR-4511	CLIP-seq
MIRT1927047	hsa-miR-4641	CLIP-seq
MIRT1927048	hsa-miR-4682	CLIP-seq
MIRT769686	hsa-miR-4722-5p	CLIP-seq
MIRT769689	hsa-miR-4768-3p	CLIP-seq
MIRT769691	hsa-miR-4802-5p	CLIP-seq
MIRT1927049	hsa-miR-500b	CLIP-seq
MIRT769692	hsa-miR-502-5p	CLIP-seq
MIRT769695	hsa-miR-515-5p	CLIP-seq
MIRT1927050	hsa-miR-616	CLIP-seq
MIRT769703	hsa-miR-766	CLIP-seq
MIRT769644	hsa-miR-1253	CLIP-seq
MIRT769646	hsa-miR-1292	CLIP-seq
MIRT2167949	hsa-miR-183	CLIP-seq
MIRT2167950	hsa-miR-203	CLIP-seq
MIRT769651	hsa-miR-2278	CLIP-seq
MIRT769652	hsa-miR-24	CLIP-seq
MIRT769653	hsa-miR-3122	CLIP-seq
MIRT769663	hsa-miR-3913-5p	CLIP-seq
MIRT769666	hsa-miR-4251	CLIP-seq
MIRT1927043	hsa-miR-4289	CLIP-seq
MIRT2167951	hsa-miR-4307	CLIP-seq
MIRT769670	hsa-miR-4422	CLIP-seq
MIRT769671	hsa-miR-4436a	CLIP-seq
MIRT1927045	hsa-miR-4438	CLIP-seq
MIRT769672	hsa-miR-4450	CLIP-seq
MIRT769673	hsa-miR-4471	CLIP-seq
MIRT769674	hsa-miR-4493	CLIP-seq
MIRT769675	hsa-miR-4499	CLIP-seq
MIRT1927046	hsa-miR-4511	CLIP-seq
MIRT769678	hsa-miR-4635	CLIP-seq
MIRT2167952	hsa-miR-4653-3p	CLIP-seq
MIRT769682	hsa-miR-4667-5p	CLIP-seq
MIRT769684	hsa-miR-4670-3p	CLIP-seq
MIRT1927048	hsa-miR-4682	CLIP-seq
MIRT769685	hsa-miR-4700-5p	CLIP-seq
MIRT769686	hsa-miR-4722-5p	CLIP-seq
MIRT769689	hsa-miR-4768-3p	CLIP-seq
MIRT769691	hsa-miR-4802-5p	CLIP-seq
MIRT769692	hsa-miR-502-5p	CLIP-seq
MIRT769696	hsa-miR-548c-3p	CLIP-seq
MIRT1927050	hsa-miR-616	CLIP-seq
MIRT769700	hsa-miR-622	CLIP-seq
MIRT769691	hsa-miR-4802-5p	CLIP-seq
MIRT769654	hsa-miR-3140-3p	CLIP-seq
MIRT2435248	hsa-miR-4686	CLIP-seq
MIRT2443281	hsa-miR-2052	CLIP-seq
MIRT2443282	hsa-miR-2355-3p	CLIP-seq
MIRT2443283	hsa-miR-4321	CLIP-seq
MIRT2443284	hsa-miR-4445	CLIP-seq
MIRT2443285	hsa-miR-4646-3p	CLIP-seq
MIRT2443286	hsa-miR-676	CLIP-seq
MIRT2443287	hsa-miR-760	CLIP-seq
MIRT769644	hsa-miR-1253	CLIP-seq
MIRT769645	hsa-miR-1266	CLIP-seq
MIRT769647	hsa-miR-154	CLIP-seq
MIRT1927040	hsa-miR-194	CLIP-seq
MIRT769650	hsa-miR-21	CLIP-seq
MIRT2470449	hsa-miR-2114	CLIP-seq
MIRT2470450	hsa-miR-2115	CLIP-seq
MIRT2470451	hsa-miR-2355-5p	CLIP-seq
MIRT2470452	hsa-miR-2467-5p	CLIP-seq
MIRT2470453	hsa-miR-298	CLIP-seq
MIRT769653	hsa-miR-3122	CLIP-seq
MIRT2470454	hsa-miR-3125	CLIP-seq
MIRT2470455	hsa-miR-3158-5p	CLIP-seq
MIRT2470456	hsa-miR-3160-3p	CLIP-seq
MIRT2470457	hsa-miR-3180-5p	CLIP-seq
MIRT769656	hsa-miR-3185	CLIP-seq
MIRT1927041	hsa-miR-362-5p	CLIP-seq
MIRT769659	hsa-miR-3664-3p	CLIP-seq
MIRT1927042	hsa-miR-3688-3p	CLIP-seq
MIRT2470458	hsa-miR-370	CLIP-seq
MIRT769663	hsa-miR-3913-5p	CLIP-seq
MIRT2470459	hsa-miR-3914	CLIP-seq
MIRT2470460	hsa-miR-3916	CLIP-seq
MIRT2470461	hsa-miR-3928	CLIP-seq
MIRT2470462	hsa-miR-4257	CLIP-seq
MIRT1927043	hsa-miR-4289	CLIP-seq
MIRT1927044	hsa-miR-433	CLIP-seq
MIRT2470463	hsa-miR-4418	CLIP-seq
MIRT769670	hsa-miR-4422	CLIP-seq
MIRT769672	hsa-miR-4450	CLIP-seq
MIRT2470464	hsa-miR-4487	CLIP-seq
MIRT769676	hsa-miR-4518	CLIP-seq
MIRT1927047	hsa-miR-4641	CLIP-seq
MIRT769682	hsa-miR-4667-5p	CLIP-seq
MIRT769683	hsa-miR-4668-3p	CLIP-seq
MIRT769685	hsa-miR-4700-5p	CLIP-seq
MIRT2470465	hsa-miR-4717-3p	CLIP-seq
MIRT2470466	hsa-miR-4766-5p	CLIP-seq
MIRT2470467	hsa-miR-4769-3p	CLIP-seq
MIRT2470468	hsa-miR-4803	CLIP-seq
MIRT1927049	hsa-miR-500b	CLIP-seq
MIRT769692	hsa-miR-502-5p	CLIP-seq
MIRT2470469	hsa-miR-509-3-5p	CLIP-seq
MIRT2470470	hsa-miR-509-5p	CLIP-seq
MIRT2470471	hsa-miR-520a-5p	CLIP-seq
MIRT2470472	hsa-miR-525-5p	CLIP-seq
MIRT769696	hsa-miR-548c-3p	CLIP-seq
MIRT769697	hsa-miR-548g	CLIP-seq
MIRT2470473	hsa-miR-549	CLIP-seq
MIRT2470474	hsa-miR-558	CLIP-seq
MIRT2470475	hsa-miR-583	CLIP-seq
MIRT769699	hsa-miR-590-5p	CLIP-seq
MIRT1927050	hsa-miR-616	CLIP-seq
MIRT2470476	hsa-miR-642b	CLIP-seq
MIRT769701	hsa-miR-652	CLIP-seq
MIRT769644	hsa-miR-1253	CLIP-seq
MIRT769645	hsa-miR-1266	CLIP-seq
MIRT769647	hsa-miR-154	CLIP-seq
MIRT1927040	hsa-miR-194	CLIP-seq
MIRT769650	hsa-miR-21	CLIP-seq
MIRT2470449	hsa-miR-2114	CLIP-seq
MIRT2470450	hsa-miR-2115	CLIP-seq
MIRT2470451	hsa-miR-2355-5p	CLIP-seq
MIRT2470452	hsa-miR-2467-5p	CLIP-seq
MIRT2470453	hsa-miR-298	CLIP-seq
MIRT2470454	hsa-miR-3125	CLIP-seq
MIRT769654	hsa-miR-3140-3p	CLIP-seq
MIRT2470455	hsa-miR-3158-5p	CLIP-seq
MIRT2470456	hsa-miR-3160-3p	CLIP-seq
MIRT2470457	hsa-miR-3180-5p	CLIP-seq
MIRT769656	hsa-miR-3185	CLIP-seq
MIRT1927041	hsa-miR-362-5p	CLIP-seq
MIRT769659	hsa-miR-3664-3p	CLIP-seq
MIRT1927042	hsa-miR-3688-3p	CLIP-seq
MIRT2470458	hsa-miR-370	CLIP-seq
MIRT2470459	hsa-miR-3914	CLIP-seq
MIRT2470460	hsa-miR-3916	CLIP-seq
MIRT2470461	hsa-miR-3928	CLIP-seq
MIRT2470462	hsa-miR-4257	CLIP-seq
MIRT1927043	hsa-miR-4289	CLIP-seq
MIRT1927044	hsa-miR-433	CLIP-seq
MIRT2470463	hsa-miR-4418	CLIP-seq
MIRT769670	hsa-miR-4422	CLIP-seq
MIRT2470464	hsa-miR-4487	CLIP-seq
MIRT769676	hsa-miR-4518	CLIP-seq
MIRT1927047	hsa-miR-4641	CLIP-seq
MIRT2674624	hsa-miR-4659a-3p	CLIP-seq
MIRT2674625	hsa-miR-4659b-3p	CLIP-seq
MIRT769683	hsa-miR-4668-3p	CLIP-seq
MIRT2435248	hsa-miR-4686	CLIP-seq
MIRT2674626	hsa-miR-4687-3p	CLIP-seq
MIRT2470465	hsa-miR-4717-3p	CLIP-seq
MIRT2470466	hsa-miR-4766-5p	CLIP-seq
MIRT2470467	hsa-miR-4769-3p	CLIP-seq
MIRT2470468	hsa-miR-4803	CLIP-seq
MIRT2674627	hsa-miR-486-5p	CLIP-seq
MIRT1927049	hsa-miR-500b	CLIP-seq
MIRT769692	hsa-miR-502-5p	CLIP-seq
MIRT2470469	hsa-miR-509-3-5p	CLIP-seq
MIRT2470470	hsa-miR-509-5p	CLIP-seq
MIRT2470471	hsa-miR-520a-5p	CLIP-seq
MIRT2470472	hsa-miR-525-5p	CLIP-seq
MIRT769696	hsa-miR-548c-3p	CLIP-seq
MIRT2470473	hsa-miR-549	CLIP-seq
MIRT2470474	hsa-miR-558	CLIP-seq
MIRT2470475	hsa-miR-583	CLIP-seq
MIRT769699	hsa-miR-590-5p	CLIP-seq
MIRT1927050	hsa-miR-616	CLIP-seq
MIRT2674628	hsa-miR-626	CLIP-seq
MIRT2470476	hsa-miR-642b	CLIP-seq
MIRT2674629	hsa-miR-647	CLIP-seq
MIRT2674630	hsa-miR-9	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	23168256
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006006	Process	Glucose metabolic process	IBA
GO:0006006	Process	Glucose metabolic process	IDA	26555263
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006096	Process	Glycolytic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016773	Function	Phosphotransferase activity, alcohol group as acceptor	IEA
GO:0043843	Function	ADP-specific glucokinase activity	EXP	23168256
GO:0043843	Function	ADP-specific glucokinase activity	IBA
GO:0043843	Function	ADP-specific glucokinase activity	IDA	26555263
GO:0043843	Function	ADP-specific glucokinase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061620	Process	Glycolytic process through glucose-6-phosphate	TAS

Other IDs

• MIM: 611861
• HGNC: 25250
• e!Ensembl: ENSG00000159322

Protein

• UniProt ID: Q9BRR6
• Protein name: ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) (RbBP-35)
• Protein function: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04587	ADP_PFK_GK	73 → 490	ADP-specific Phosphofructokinase/Glucokinase conserved region	Family

• Sequence:

  MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAA
  WDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFI
  HFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGP
  VGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAM
  NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS
  MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILF
  WILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI
  DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLG
  DAISAEGLFYSEVHPHY

• Sequence length: 497

Pathways

KEGG Pathway	Reactome Pathway
Glycolysis / Gluconeogenesis	Glycolysis
Metabolic pathways
Carbon metabolism

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GAPDHS 2 shared pathwaysGlycolysis / Gluconeogenesis, Glycolysis Related via 2 shared pathways including Glycolysis / Gluconeogenesis, Glycolysis. ENO4 2 shared pathwaysGlycolysis / Gluconeogenesis, Carbon metabolism Related via 2 shared pathways including Glycolysis / Gluconeogenesis, Carbon metabolism. PGK2 3 shared pathwaysGlycolysis / Gluconeogenesis, Carbon metabolism, Glycolysis Related via 3 shared pathways including Glycolysis / Gluconeogenesis, Carbon metabolism. BPGM 2 shared pathwaysGlycolysis / Gluconeogenesis, Glycolysis Related via 2 shared pathways including Glycolysis / Gluconeogenesis, Glycolysis. PGK1 3 shared pathwaysGlycolysis / Gluconeogenesis, Carbon metabolism, Glycolysis Related via 3 shared pathways including Glycolysis / Gluconeogenesis, Carbon metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GAPDHS	0	[]	2	["Glycolysis \/ Gluconeogenesis","Glycolysis"]	0	[]
ENO4	0	[]	2	["Glycolysis \/ Gluconeogenesis","Carbon metabolism"]	0	[]
PGK2	0	[]	3	["Glycolysis \/ Gluconeogenesis","Carbon metabolism","Glycolysis"]	0	[]
BPGM	0	[]	2	["Glycolysis \/ Gluconeogenesis","Glycolysis"]	0	[]
PGK1	0	[]	3	["Glycolysis \/ Gluconeogenesis","Carbon metabolism","Glycolysis"]	0	[]

Diseases Linked via Similar Genes

Hemolytic anemia Linked via 2 of 5 related genesBPGM, PGK1 Alzheimer disease Linked via 1 of 5 related genesGAPDHS Liver disease Linked via 1 of 5 related genesGAPDHS Cannabis abuse Linked via 1 of 5 related genesENO4 Male infertility Linked via 1 of 5 related genesENO4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hemolytic anemia	2	["BPGM","PGK1"]
Alzheimer disease	1	["GAPDHS"]
Liver disease	1	["GAPDHS"]
Cannabis abuse	1	["ENO4"]
Male infertility	1	["ENO4"]