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Gene Gene information from NCBI Gene database.
Entrez ID 133
Gene name Adrenomedullin
Gene symbol ADM
Synonyms (NCBI Gene)
AMPAMP
Chromosome 11
Chromosome location 11p15.4
Summary The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, re
miRNA miRNA information provided by mirtarbase database.
956 Show/Hide all (956)
miRTarBase ID miRNA Experiments Reference
MIRT029565 hsa-miR-26b-5p Sequencing 20371350
MIRT050138 hsa-miR-26a-5p CLASH 23622248
MIRT045894 hsa-miR-125b-5p CLASH 23622248
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
CEBPB Activation 9480831
CEBPB Unknown 12630823
GTF3A Unknown 12630823
TFAP2A Unknown 10848972
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48 Show/Hide all (48)
GO ID Ontology Definition Evidence Reference
GO:0001570 Process Vasculogenesis IDA 16964401
GO:0001843 Process Neural tube closure IEA
GO:0001878 Process Response to yeast IDA 10225288
GO:0002031 Process G protein-coupled receptor internalization IDA 10882736
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
103275 259 ENSG00000148926
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35318
Protein name Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)]
Protein function Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologi
PDB 2FLY , 2L7S , 4RWF , 5V6Y , 6UUN , 6UUS , 6V2E , 7VV0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 → 151 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. {ECO:0000269|PubMed:8387282}.
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Neuroactive ligand-receptor interaction G alpha (s) signalling events
Vascular smooth muscle contraction Calcitonin-like ligand receptors
  ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (11)
Phenotype Name Clinical Significance Source Reference Evidence Score
AUTISTIC DISORDER — CTD, Disgenet
CTD, Disgenet
12579522
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN INFARCTION — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTRIC ULCER — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (350)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 25879330
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 30250620
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 31322275
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 17363587, 21839130
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 22923200
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 17290391
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Cortical Adenoma Adrenocortical adenoma LHGDN 11712085
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Cortical Adenoma Adrenocortical adenoma BEFREE 9487993
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 10795919, 10848972, 11032871, 11318031, 11747138, 11921351, 12441221, 15206165, 16112409, 16153719, 16616959, 16769769, 17100569, 17102095, 17952853
View all (17 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenocortical carcinoma Adrenocortical carcinoma BEFREE 11078430, 15702240
★★★★★
★☆☆☆☆
Found in Text Mining only