ACSM4 (acyl-CoA synthetase medium chain family member 4)

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Gene Gene information from NCBI Gene database.
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Entrez ID 341392
Gene name Acyl-CoA synthetase medium chain family member 4
Gene symbol ACSM4
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12p13.31
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
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GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004321 Function Fatty-acyl-CoA synthase activity IBA
GO:0005524 Function ATP binding IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
614360 32016 ENSG00000215009
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0C7M7
Protein name Acyl-coenzyme A synthetase ACSM4, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 4)
Protein function Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity). {ECO:0000250|
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00501 AMP-binding 63 → 478 AMP-binding enzyme Family
PF13193 AMP-binding_C 486 → 566 AMP-binding enzyme C-terminal domain Domain
Sequence 
MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLD
QWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVI
LPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVL
ECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQ
HSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQF
DTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRV
QTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIA
LRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGY
RIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHV
KKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR
Sequence length 580
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Butanoate metabolism Conjugation of salicylate with glycine
Metabolic pathways  
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ACSM2A 2 shared pathwaysButanoate metabolism, Conjugation of salicylate with glycine Related via 2 shared pathways including Butanoate metabolism, Conjugation of salicylate with glycine. ACSM5 2 shared pathwaysButanoate metabolism, Conjugation of salicylate with glycine Related via 2 shared pathways including Butanoate metabolism, Conjugation of salicylate with glycine. ACSM2B 2 shared pathwaysButanoate metabolism, Conjugation of salicylate with glycine Related via 2 shared pathways including Butanoate metabolism, Conjugation of salicylate with glycine.
Astrocytoma Linked via 2 of 3 related genesACSM2A, ACSM2B Central nervous system cancer Linked via 2 of 3 related genesACSM2A, ACSM2B Glioma Linked via 2 of 3 related genesACSM2A, ACSM2B Gout Linked via 2 of 3 related genesACSM2A, ACSM2B Hyperpituitarism Linked via 1 of 3 related genesACSM2A