Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 53
Gene name Acid phosphatase 2, lysosomal
Gene symbol ACP2
Synonyms (NCBI Gene)
LAP
Chromosome 11
Chromosome location 11p11.2|11p12-p11
Summary The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from th
miRNA miRNA information provided by mirtarbase database.
490 Show/Hide all (490)
miRTarBase ID miRNA Experiments Reference
MIRT001481 hsa-miR-16-5p pSILAC 18668040
MIRT023652 hsa-miR-1-3p Proteomics 18668040
MIRT028470 hsa-miR-30a-5p Proteomics 18668040
MIRT001481 hsa-miR-16-5p Proteomics;Other 18668040
MIRT763199 hsa-miR-1260 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development IEA
GO:0003993 Function Acid phosphatase activity IBA
GO:0003993 Function Acid phosphatase activity IEA
GO:0003993 Function Acid phosphatase activity TAS 3191910
GO:0005515 Function Protein binding IPI 28514442, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
171650 123 ENSG00000134575
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11117
Protein name Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00328 His_Phos_2 32 → 330 Histidine phosphatase superfamily (branch 2) Family
Sequence
Sequence length 423
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Riboflavin metabolism
Metabolic pathways
Lysosome
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
ANTI-NMDA RECEPTOR ENCEPHALITIS — GWAS catalog 34584012
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Familial cancer of breast Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION — GWAS catalog 36187959
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA — GWAS catalog 35835914
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME — GWAS catalog 39349817
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (9)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acid Phosphatase Deficiency Acid Phosphatase Deficiency CTD_human_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 15967798 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 28076332 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Juvenile Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis BEFREE 17868323
★★★★★
★☆☆☆☆
Found in Text Mining only
Keratoconus Keratoconus BEFREE 9040486
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 1688712
★★★★★
★☆☆☆☆
Found in Text Mining only
Mucopolysaccharidosis VI Mucopolysaccharidosis BEFREE 30075049
★★★★★
★☆☆☆☆
Found in Text Mining only
Regular astigmatism - corneal Corneal astigmatism BEFREE 29422769
★★★★★
★☆☆☆☆
Found in Text Mining only
Supranuclear Palsy Progressive Progressive supranuclear palsy Pubtator 17357082 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only