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Gene Gene information from NCBI Gene database.
Entrez ID 60496
Gene name Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Gene symbol AASDHPPT
Synonyms (NCBI Gene)
AASD-PPTACPSCGI-80LYS2LYS5
Chromosome 11
Chromosome location 11q22.3
Summary The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynt
miRNA miRNA information provided by mirtarbase database.
630 Show/Hide all (630)
miRTarBase ID miRNA Experiments Reference
MIRT021758 hsa-miR-132-3p Microarray 17612493
MIRT024906 hsa-miR-215-5p Microarray 19074876
MIRT026270 hsa-miR-192-5p Microarray 19074876
MIRT027472 hsa-miR-98-5p Microarray 19088304
MIRT624884 hsa-miR-194-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18 Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 18022563
GO:0000287 Function Magnesium ion binding IEA
GO:0005515 Function Protein binding IPI 16189514, 18022563, 19615732, 25416956, 28514442, 32296183, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607756 14235 ENSG00000149313
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NRN7
Protein name L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog)
Protein function Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, t
PDB 2BYD , 2C43 , 2CG5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01648 ACPS 125 → 244 Domain
Tissue specificity TISSUE SPECIFICITY: Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048}.
Sequence
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAA
MAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAA
EPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALK
ESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHF
VAVA
LRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEE
IPIRNGTKS
Sequence length 309
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Pantothenate and CoA biosynthesis Vitamin B5 (pantothenate) metabolism
Metabolic pathways