Enrichment Analysis?
How to use
- Paste your gene symbols into the box below (comma or newline separated), upload a .txt/.csv file, or click one of the example links to try it out.
- Select the Organism if your genes aren't human — non-human symbols are automatically mapped to their human orthologs before analysis.
- Tissue and Disease Names aren't used for this analysis — they only apply to the other three buttons below.
- Click Pathway Enrichment. You'll first see which of your genes were recognized and which weren't, then be taken to the results.
What you get
- A bar chart of KEGG pathways significantly enriched in your gene list — by default those with a Benjamini–Hochberg adjusted p-value (q-value) below 0.05 — ranked most-significant first and color-coded by significance. You can switch the filter to the raw p-value.
- A results table listing each enriched pathway name, the matched genes (linked to their gene pages), the gene overlap ratio (matched genes ÷ total genes in that pathway), the hypergeometric p-value, the fold enrichment and the q-value.
- Checkboxes to select pathways of interest and run a gene network analysis on them.
- Download buttons to export the results table as CSV or PDF, and the chart as PNG or JPEG.
Note: Analysis is computationally intensive. Results may take some time depending on the number of genes provided.
⚠ Tissue selection is required for tissue-specific pathway enrichment analysis.
Cite us: DOI: 10.1016/j.gendis.2022.05.034