Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▲ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Ocular hypertension | Peripheral vertigo |
1 gene
Show details
OTOGL(1)
|
0.019 | 0.200 | 1.58e-2 | 1.74e-2 ✓ sig. | — | |
| Cardiomyopathy | primary ciliary dyskinesia 2 |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | nemaline myopathy 5 |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | Mitochondrial encephalocardiomyopathy |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | cardiomyopathy, dilated, 2d |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | cardiomyopathy, dilated, 2f |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | Danon disease |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Barth syndrome | Cardiomyopathy |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Beta-sarcoglycanopathy | Cardiomyopathy |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | dilated cardiomyopathy 1CC |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | dilated cardiomyopathy 1M |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | Cluster 369 → | |
| Cardiomyopathy | dilated cardiomyopathy 1Z |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | DK1-congenital disorder of glycosylation |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | DPM3-congenital disorder of glycosylation |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | Vici syndrome |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | xeroderma pigmentosum group E |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Cardiomyopathy | intrinsic cardiomyopathy |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Amish nemaline myopathy | Cardiomyopathy |
1 gene
|
0.004 | 1.000 | 1.58e-2 | 1.75e-2 ✓ sig. | — | |
| Pernicious anemia | Seborrheic keratosis |
1 gene
Show details
POU2F3(1)
|
0.026 | 0.125 | 1.60e-2 | 1.76e-2 ✓ sig. | — | |
| Skin cancer | Uncombable hair syndrome |
1 gene
|
0.012 | 0.333 | 1.61e-2 | 1.77e-2 ✓ sig. | — | |
| Adenosine kinase deficiency | Diverticular disease |
1 gene
|
0.004 | 1.000 | 1.62e-2 | 1.78e-2 ✓ sig. | — | |
| Biotinidase deficiency | Diverticular disease |
1 gene
|
0.004 | 1.000 | 1.62e-2 | 1.78e-2 ✓ sig. | — | |
| Diverticular disease | macular corneal dystrophy |
1 gene
|
0.004 | 1.000 | 1.62e-2 | 1.78e-2 ✓ sig. | — | |
| Congenital insufficiency of mitral valve | Diverticular disease |
1 gene
|
0.004 | 1.000 | 1.62e-2 | 1.78e-2 ✓ sig. | — | |
| Diverticular disease | schneckenbecken dysplasia |
1 gene
|
0.004 | 1.000 | 1.62e-2 | 1.78e-2 ✓ sig. | — |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.