complex neurodevelopmental disorder

Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +15 more

Lysosome Human immunodeficiency virus 1 infection Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis +3 more

Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance +17 more

ATP-dependent chromatin remodeling

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cellular senescence Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Tight junction Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Carbohydrate digestion and absorption Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +35 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +8 more

MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Oxytocin signaling pathway Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions +9 more

ErbB signaling pathway Calcium signaling pathway cAMP signaling pathway HIF-1 signaling pathway Oocyte meiosis Efferocytosis Necroptosis Adrenergic signaling in cardiomyocytes Wnt signaling pathway Axon guidance Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Oxytocin signaling pathway Glucagon signaling pathway Aldosterone synthesis and secretion Cushing syndrome Gastric acid secretion Parkinson disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Pathways in cancer Proteoglycans in cancer Glioma Diabetic cardiomyopathy Lipid and atherosclerosis HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Ion transport by P-type ATPases Signaling downstream of RAS mutants +45 more

Estrogen-dependent gene expression

Wnt signaling pathway Deactivation of the beta-catenin transactivating complex

Spinocerebellar ataxia

RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Cell adhesion molecules

Cell adhesion molecules

Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis +4 more

Spliceosome mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway

RAB GEFs exchange GTP for GDP on RABs

Hippo signaling pathway Glutamatergic synapse Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Synaptic adhesion-like molecules +10 more

Trafficking of AMPA receptors Neurexins and neuroligins

Ras signaling pathway Salmonella infection Insulin processing VxPx cargo-targeting to cilium +1 more

Insulin signaling pathway Salmonella infection Insulin processing VxPx cargo-targeting to cilium +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction GABAergic synapse Taste transduction Estrogen signaling pathway GnRH secretion Morphine addiction Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +9 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling Serotonergic synapse GABAergic synapse Morphine addiction Nicotine addiction GABA receptor activation +4 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Morphine addiction Nicotine addiction +2 more

Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Axon guidance Apelin signaling pathway Gap junction Platelet activation Leukocyte transendothelial migration Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Gastric acid secretion Parkinson disease Cocaine addiction Morphine addiction Alcoholism Pertussis Chagas disease Toxoplasmosis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PLC beta mediated events Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling +47 more

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +43 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Dopaminergic synapse Long-term depression Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Nicotine addiction COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules +18 more

Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor +1 more

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +20 more

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Dopaminergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Systemic lupus erythematosus Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +19 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Unblocking of NMDA receptors, glutamate binding and activation RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +16 more

cAMP signaling pathway GnRH secretion HCN channels

Antigen processing: Ubiquitination & Proteasome degradation

AUF1 (hnRNP D0) binds and destabilizes mRNA mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Spliceosome mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Endocytosis

Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Voltage gated Potassium channels

Cholinergic synapse Voltage gated Potassium channels

Neddylation Antigen processing: Ubiquitination & Proteasome degradation