Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
uterine carcinosarcoma	MONDO_0006485	NUTM2B	Unknown	22223660	Open Targets	—
		PALB2	Unknown	33021035	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PAX3	Unknown	28940304	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	33503190	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	28940304	Open Targets	Transcriptional misregulation in cancer
		PBRM1	Unknown	33021035	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PDGFB	Unknown	33021035	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDGFRB	Unknown	33021035	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	23656649 21168197 24561032 30266945 25078343 31217897 28940304 33503190 22498935 23896716 33021035 22653804 27302833 39040939 25233892 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	27491810 33021035 25233892 28481359 30266945	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PLAG1	Unknown	28940304	Open Targets	—
		PLEC	Unknown	33021035	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		POLD1	Unknown	33021035	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	38571325 28940304 33021035 39040939 25233892 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLR2A	Unknown	33021035	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		PPARG	Unknown	33021035	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPP2R1A	Unknown	30266945 33021035 28481359 28940304 22653804	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	25233892	Open Targets	COPII-mediated vesicle transport
		PRKAR1A	Unknown	33021035 28940304	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PTCH1	Unknown	28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTPRB	Unknown	33021035	Open Targets	Adherens junction Neutrophil degranulation
		PTPRK	Unknown	33021035	Open Targets	EGFR downregulation
		PTPRT	Unknown	33021035 28481359	Open Targets	—
		RAD50	Unknown	28481359	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RANBP2	Unknown	28940304	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1GDS1	Unknown	33021035	Open Targets	—
		RASA1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	33021035 28481359 28940304	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	33021035	Open Targets	—
		RET	Unknown	28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGPD3	Unknown	28940304	Open Targets	—
		RNF213	Unknown	33021035 28940304	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	33021035 25233892	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	33021035	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROS1	Unknown	33021035 28481359	Open Targets	—
		SALL4	Unknown	33021035	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SEPTIN6	Unknown	33021035	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETD1B	Unknown	33021035	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SF3B1	Unknown	21995386	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SH2B3	Unknown	33021035	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SKI	Unknown	33021035	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SLC45A3	Unknown	33021035	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Cellular hexose transport
		SMARCA4	Unknown	33503190 33021035	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	17376508	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMC1A	Unknown	33021035 28940304	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SOS1	Unknown	30266945	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SPEN	Unknown	28481359 28940304	Open Targets	Notch signaling pathway
		SPOP	Unknown	25233892 28940304	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	33503190	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more

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Uterine carcinosarcoma

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