Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
uterine carcinosarcoma	MONDO_0006485	PTEN	Causal	30266945 30908539 27491810 22498935 33021035 11925138 22653804 27302833 39040939 25233892 28481359 26373574	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		TP53	Causal	8272291 12144684 21168197 30266945 31217897 30908539 28940304 33503190 33021035 22653804 39040939 25233892 28481359 26373574	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		ABL1	Unknown	28481359	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ACVR1B	Unknown	33021035	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		AFDN	Unknown	33021035	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF4	Unknown	28940304	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKT1	Unknown	28481359 28940304	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	30266945	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		AKT3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +119 more
		ALK	Unknown	25233892 28481359	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	28481359	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ANK1	Unknown	33021035	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	33503190 33021035 28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	33021035 28940304	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP35	Unknown	33021035 30266945 28940304	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	33021035	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10L	Unknown	33021035	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	33021035	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	28481359 28940304 33503190 33021035 22653804 25233892 30266945	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	25233892 33021035	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	33021035	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	33503190 28481359 33021035 27491810	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP2B3	Unknown	33021035	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	25233892	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	25233892 28940304	Open Targets	Cell cycle
		AXIN1	Unknown	25233892	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	25233892	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BAP1	Unknown	33503190 28940304	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BAZ1A	Unknown	33021035	Open Targets	ATP-dependent chromatin remodeling
		BCL6	Unknown	33021035	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL9	Unknown	33021035	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCOR	Unknown	33021035 25233892	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	33021035	Open Targets	Polycomb repressive complex
		BCR	Unknown	28940304	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC6	Unknown	33021035	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BMP5	Unknown	33021035	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BRAF	Unknown	25233892 30266945 22653804	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	25233892	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	25233892 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	33021035 28940304	Open Targets	—
		BRD4	Unknown	33021035	Open Targets	—
		BRIP1	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		CACNA1D	Unknown	33021035	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CAMTA1	Unknown	33021035	Open Targets	—
		CARD11	Unknown	28481359	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CCND1	Unknown	30266945	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CD209	Unknown	33021035	Open Targets	Virion - Human immunodeficiency virus Virion - Flavivirus and Alphavirus Virion - Ebolavirus, Lyssavirus and Morbillivirus +7 more

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Uterine carcinosarcoma

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