Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
uterine carcinosarcoma	MONDO_0006485	GRIN2A	Unknown	33021035	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GTF2I	Unknown	28940304	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		HGF	Unknown	28940304	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HNF1A	Unknown	28481359	Open Targets	Maturity onset diabetes of the young
		IDH2	Unknown	25233892	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IRS4	Unknown	33021035	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		JAK1	Unknown	33503190 25233892	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	33503190	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	28940304	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KCNJ5	Unknown	33021035	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5C	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	33503190	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KEAP1	Unknown	28940304	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KLF4	Unknown	33021035	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KMT2A	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	33021035 25233892	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	33503190 33021035 28481359 30266945	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	7856726 11520156 21168197 27302833 31217897 28940304 16256179 22498935 33021035 22653804 11179836 25233892 28481359 26373574	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LOC100506403	Unknown	33021035 28481359	Open Targets	—
		LRP1B	Unknown	33021035	Open Targets	—
		LZTR1	Unknown	33021035	Open Targets	—
		MAP2K1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP3K1	Unknown	28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	33021035	Open Targets	MAPK signaling pathway
		MED12	Unknown	28481359 28940304	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	33503190	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLF1	Unknown	28940304	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	25233892	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH2	Unknown	27302833 7585651 25194673	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	25233892 28481359 28940304	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	33503190 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC6	Unknown	33021035	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	28481359	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		NBN	Unknown	28481359	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA2	Unknown	33021035	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR2	Unknown	33021035	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	33503190 33021035	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFATC2	Unknown	28940304	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFKBIE	Unknown	25233892	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NOTCH1	Unknown	33503190	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	25233892	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	21168197 28940304	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	28940304	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	33021035 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK3	Unknown	28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUP98	Unknown	33021035	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM2B	Unknown	22223660	Open Targets	—
		PALB2	Unknown	33021035	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more

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Uterine carcinosarcoma

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