Subtype of: Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Thyroid Gland Oncocytic Follicular Carcinoma	EFO_1000592	MUC16	Unknown	25625803 30107175	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYO5A	Unknown	30107175	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBEA	Unknown	30107175	Open Targets	—
		NCOA4	Unknown	16595592 25111330 14668719 21498916 11788677 20703476	Open Targets	Ferroptosis Pathways in cancer Thyroid cancer
		NCOR1	Unknown	34680332	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	30107175	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NDRG1	Unknown	30107175	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NF1	Unknown	30107175	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFATC2	Unknown	30107175	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	30107175	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFKB2	Unknown	30107175	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NOTCH1	Unknown	30107175	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	30107175	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	22650231 28781658 23543667 30107175 9889797	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK1	Unknown	11216646 30107175 23543667	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		PAX8	Unknown	16728576 12519876 23543667 22803838 19963130 30107175 12170088 23881852	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PCM1	Unknown	14668719	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PIK3CA	Unknown	22675538 16288007	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PLEC	Unknown	30107175	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PMS2	Unknown	30107175	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLR2A	Unknown	30107175	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		PPARG	Unknown	16728576 12519876 23543667 22803838 19963130 12170088 23881852	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPM1D	Unknown	30107175	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	30107175	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PRDM16	Unknown	30107175	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRKAR1A	Unknown	14668719 11788677	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRRX1	Unknown	30107175	Open Targets	—
		PSIP1	Unknown	30107175	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTEN	Unknown	30107175	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN6	Unknown	30107175	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRT	Unknown	30107175	Open Targets	—
		RAD51C	Unknown	29615459	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RET	Unknown	16595592 25111330 14668719 30107175 21498916 11788677 20703476	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		ROS1	Unknown	30107175	Open Targets	—
		RPL22	Unknown	30107175	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	30107175	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		SDC4	Unknown	30107175	Open Targets	ECM-receptor interaction Cell adhesion molecules Cytoskeleton in muscle cells +13 more
		SEPTIN6	Unknown	25625803	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETD2	Unknown	25625803 30107175	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SH3GL1	Unknown	30107175	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SMAD3	Unknown	30107175	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	15940269	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCD1	Unknown	25625803 30107175	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SOS1	Unknown	34680332	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SPEN	Unknown	30107175	Open Targets	Notch signaling pathway
		SRC	Unknown	30107175	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRGAP3	Unknown	30107175	Open Targets	Axon guidance Rho GTPase cycle
		SS18L1	Unknown	30107175	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STRN	Unknown	24475247	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TERT	Unknown	30107175 25259908	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more

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Thyroid gland oncocytic follicular carcinoma

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