Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
thyroid gland oncocytic adenoma	MONDO_0004483	NRAS	Unknown	28481359 37760447 2247846	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK1	Unknown	23543667	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		PAX5	Unknown	30107175	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX8	Unknown	20099311 19963130 22803838 12170088 23543667	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PCM1	Unknown	14668719	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		POLD1	Unknown	28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPARG	Unknown	20099311 19963130 22803838 12170088 23543667	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PRDM2	Unknown	30107175	Open Targets	Lysine degradation Metabolic pathways
		PRKAR1A	Unknown	14668719 11788677	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PTCH1	Unknown	28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	30107175 29615459 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRD	Unknown	28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	28481359	Open Targets	—
		RARA	Unknown	28481359	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RB1	Unknown	28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	28481359	Open Targets	—
		RET	Unknown	9001272 20099311 16595592 20924280 25111330 14668719 11788677 17727338 20703476	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		SDHB	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SH2B3	Unknown	30107175	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMAD4	Unknown	29615459 15940269	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		STRN	Unknown	24475247	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TBX3	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TFG	Unknown	23543667	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TNFRSF14	Unknown	29615459	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TNRC18	Unknown	30107175	Open Targets	—
		TP53	Unknown	30107175 29615459 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	28481359	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	23543667	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	23543667	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRIM24	Unknown	14668719	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	14668719	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	14668719	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TSC2	Unknown	28481359	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		VHL	Unknown	28481359	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		ZRSR2	Unknown	28481359	Open Targets	mRNA Splicing - Minor Pathway

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Thyroid gland oncocytic adenoma

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