Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
thyroid gland oncocytic adenoma	MONDO_0004483	AKAP9	Unknown	23543667	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		ALK	Unknown	24475247 28481359	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ARID1A	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	29615459 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	30107175 29615459 28481359	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	28481359	Open Targets	Cell cycle
		BCOR	Unknown	28481359	Open Targets	Polycomb repressive complex
		BRAF	Unknown	23543667	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	29615459 28481359	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		CBL	Unknown	28481359	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CCDC6	Unknown	9001272 20099311 16595592 20924280 25111330 14668719 11788677 17727338 20703476	Open Targets	Pathways in cancer Thyroid cancer
		CDH1	Unknown	28481359	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDH10	Unknown	30107175	Open Targets	Adherens junctions interactions
		CDKN1A	Unknown	29615459	Open Targets	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CLTCL1	Unknown	30107175	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +8 more
		CSF1R	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		DAXX	Unknown	29615459 28481359	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DICER1	Unknown	28481359	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNMT3A	Unknown	30107175 28481359	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EP300	Unknown	28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPHA3	Unknown	28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERC1	Unknown	14668719	Open Targets	NF-kappa B signaling pathway
		ETV1	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FANCA	Unknown	30107175	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAT1	Unknown	28481359	Open Targets	—
		FBXO11	Unknown	28481359	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FIP1L1	Unknown	30107175	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FLCN	Unknown	29615459	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		GOLGA5	Unknown	14668719	Open Targets	Intra-Golgi traffic
		GRIN2A	Unknown	28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		HOOK3	Unknown	14668719	Open Targets	Motor proteins
		HRAS	Unknown	12727991	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IKBKB	Unknown	30107175	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IL21R	Unknown	30107175	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		KEAP1	Unknown	29615459 28481359	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KMT2C	Unknown	29615459 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	29615459	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	14668719	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LATS1	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LMNA	Unknown	30107175	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		MAX	Unknown	28481359	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MSH6	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		NCOA4	Unknown	9001272 20099311 16595592 20924280 25111330 14668719 11788677 17727338 20703476	Open Targets	Ferroptosis Pathways in cancer Thyroid cancer
		NF1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFE2L2	Unknown	28481359	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more

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Thyroid gland oncocytic adenoma

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