Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
T-cell prolymphocytic leukemia	MONDO_0019468	MYH9	Unknown	24825865 26437031	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	24825865 26437031	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		MYOD1	Unknown	24825865	Open Targets	Spinocerebellar ataxia Myogenesis
		NAB2	Unknown	24825865	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NACA	Unknown	24825865	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	24825865 26437031	Open Targets	—
		NCOR2	Unknown	24825865	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NOTCH1	Unknown	17483057 20823234 24825865 26437031 32843425	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	24825865 27203213	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NR4A3	Unknown	24825865 26437031	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NTRK1	Unknown	24825865	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NUTM1	Unknown	24825865	Open Targets	—
		NUTM2D	Unknown	24825865	Open Targets	—
		PCM1	Unknown	24825865	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PER1	Unknown	24825865	Open Targets	Circadian rhythm Circadian entrainment
		PLEC	Unknown	24825865	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	24825865	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS2	Unknown	24825865 27203213	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLQ	Unknown	24825865	Open Targets	HDR through MMEJ (alt-NHEJ)
		POT1	Unknown	24825865 26437031 26574607	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		PPFIBP1	Unknown	24825865	Open Targets	Receptor-type tyrosine-protein phosphatases
		PRDM2	Unknown	24825865 26437031	Open Targets	Lysine degradation Metabolic pathways
		PRPF40B	Unknown	24825865	Open Targets	Spliceosome
		RALGDS	Unknown	24825865	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RFWD3	Unknown	24825865	Open Targets	—
		RGPD3	Unknown	24825865	Open Targets	—
		RICTOR	Unknown	24825865	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		ROCK1	Unknown	24825865	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		SH2B3	Unknown	24825865	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SIRPA	Unknown	24825865 26437031	Open Targets	Efferocytosis Osteoclast differentiation Cell surface interactions at the vascular wall +2 more
		SMARCA4	Unknown	24825865 26551667	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCD1	Unknown	24825865 27203213	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SPEN	Unknown	24825865	Open Targets	Notch signaling pathway
		STRN	Unknown	24825865 26437031	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TBX3	Unknown	24825865 26437031	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF12	Unknown	24825865	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF7L2	Unknown	24825865	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TET1	Unknown	24825865	Open Targets	—
		TET2	Unknown	26437031 26574607 26763362 26880370 26917488 28881727	Open Targets	—
		TFEB	Unknown	24825865	Open Targets	Calcium signaling pathway Mitophagy - animal
		TLX1	Unknown	24825865	Open Targets	Transcriptional misregulation in cancer
		TNC	Unknown	24825865 26437031	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNRC18	Unknown	24825865	Open Targets	—
		TSC2	Unknown	24825865	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		USP6	Unknown	24825865	Open Targets	—
		USP9X	Unknown	24825865	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		WDCP	Unknown	24825865	Open Targets	—
		ZCCHC8	Unknown	24825865 26437031	Open Targets	—
		ZNF429	Unknown	24825865 26437031	Open Targets	Generic Transcription Pathway

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T-cell prolymphocytic leukemia

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