Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
T-cell prolymphocytic leukemia	MONDO_0019468	GTF2I	Unknown	24825865	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		H3-3A	Unknown	24825865 27203213	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		HGF	Unknown	24825865 26437031	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HNF1A	Unknown	24825865	Open Targets	Maturity onset diabetes of the young
		HOOK3	Unknown	24825865	Open Targets	Motor proteins
		HOXA11	Unknown	24825865	Open Targets	Transcriptional misregulation in cancer
		IL6ST	Unknown	24825865	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	24825865	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		ISX	Unknown	24825865	Open Targets	—
		JAK3	Unknown	21821710 24048415 24446122 24825865 26437031 26917488 32843425	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JAZF1	Unknown	24825865	Open Targets	—
		KAT6A	Unknown	24825865 27203213	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KCNJ5	Unknown	24825865	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	24825865	Open Targets	HDMs demethylate histones
		KDR	Unknown	24825865 26437031	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KDSR	Unknown	24825865	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KIAA1549	Unknown	24825865	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	24825865	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KLK2	Unknown	24825865	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	24825865	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	24825865 26437031 26880370	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	24825865 26437031 26880370 27203213	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	24825865	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	24825865	Open Targets	—
		KTN1	Unknown	24825865	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	24825865	Open Targets	—
		LCP1	Unknown	24825865	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	24825865	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LRIG3	Unknown	24825865	Open Targets	—
		LRP1B	Unknown	24825865 26437031 33562071	Open Targets	—
		LYL1	Unknown	24825865	Open Targets	Transcriptional misregulation in cancer NGF-stimulated transcription
		MAF	Unknown	24825865 26437031	Open Targets	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MALT1	Unknown	24825865	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	24825865 26437031	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP3K1	Unknown	24825865	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	24825865 26437031	Open Targets	MAPK signaling pathway
		MAX	Unknown	24825865	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MB21D2	Unknown	24825865	Open Targets	—
		MED12	Unknown	24825865 26437031 27203213	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MGMT	Unknown	24825865	Open Targets	MGMT-mediated DNA damage reversal
		MLLT1	Unknown	24825865	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MN1	Unknown	24825865 26437031	Open Targets	—
		MRTFA	Unknown	24825865	Open Targets	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSH6	Unknown	24825865	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSN	Unknown	24825865	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTOR	Unknown	24825865 26437031	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC1	Unknown	24825865	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MUC4	Unknown	24825865 26437031	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	24825865	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYC	Unknown	24825865	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more

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T-cell prolymphocytic leukemia

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